NO20045219L - Kalsitonin-gen-relaterte peptid-reseptor-antagonister - Google Patents

Kalsitonin-gen-relaterte peptid-reseptor-antagonister

Info

Publication number
NO20045219L
NO20045219L NO20045219A NO20045219A NO20045219L NO 20045219 L NO20045219 L NO 20045219L NO 20045219 A NO20045219 A NO 20045219A NO 20045219 A NO20045219 A NO 20045219A NO 20045219 L NO20045219 L NO 20045219L
Authority
NO
Norway
Prior art keywords
treatment
related peptide
calcitonin gene
gene related
receptor antagonists
Prior art date
Application number
NO20045219A
Other languages
English (en)
Other versions
NO332691B1 (no
Inventor
Gene Michael Dubowchik
George N Karageorge
Prasad V Chaturvedula
Rita L Civiello
Xiaojun Han
John E Macor
Ling Chen
Charles Mark Conway
Andrew P Degnan
Guanglin Luo
Graham Poindexter
Shikha Vig
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20045219L publication Critical patent/NO20045219L/no
Publication of NO332691B1 publication Critical patent/NO332691B1/no

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/2807—Headache; Migraine

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Abstract

Legemiddel Foreliggende oppfinnelse angår forbindelser med formel (I) (D som antagonister til kalsitonin-gen-relaterte peptid-reseptorer ("CGRP-reseptor")« farmasøytiske preparater omfattende dem, metoder for å Identifisere dem, meto- der for behandling ved anvendelse av dem, og anvendelse av dem i en terapi for behandling av nevrogen vasodllatasjon, nevrogen Inflammasjon, migrene og an- nen hodepine, forbrenning, sirkulatorisk sjokk, hetetokter forbundet med meno- pause, inflammatoriske luftveissykdommer, så som astma og kronisk obstruktiv lungesykdom (KOLS), og andre tilstander der behandling av den kan utføres ved antagonisme av CGRP-reseptorer.
NO20045219A 2002-06-05 2004-11-29 Kalsitonin-gen-relaterte peptid-reseptor-antagonister samt anvendelse av disse for fremstilling av et farmasoytisk preparat for behandling av migrene NO332691B1 (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38613802P 2002-06-05 2002-06-05
US38861702P 2002-06-13 2002-06-13
US38987002P 2002-06-19 2002-06-19
US39320002P 2002-07-01 2002-07-01
US41353402P 2002-09-25 2002-09-25
PCT/US2003/016576 WO2003104236A1 (en) 2002-06-01 2003-05-27 Calcitonin gene related peptide receptor antagonists

Publications (2)

Publication Number Publication Date
NO20045219L true NO20045219L (no) 2005-02-28
NO332691B1 NO332691B1 (no) 2012-12-10

Family

ID=29741144

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045219A NO332691B1 (no) 2002-06-05 2004-11-29 Kalsitonin-gen-relaterte peptid-reseptor-antagonister samt anvendelse av disse for fremstilling av et farmasoytisk preparat for behandling av migrene

Country Status (24)

Country Link
US (2) US20040063735A1 (no)
EP (1) EP1539766B1 (no)
JP (1) JP4490809B2 (no)
KR (2) KR20120004541A (no)
CN (1) CN100558728C (no)
AU (1) AU2003237255B8 (no)
BR (1) BRPI0311812B8 (no)
CA (1) CA2487976C (no)
CY (1) CY1118764T1 (no)
DK (1) DK1539766T3 (no)
ES (1) ES2616539T3 (no)
GE (1) GEP20074231B (no)
HR (1) HRP20041147A2 (no)
HU (1) HUE032132T2 (no)
IS (1) IS7583A (no)
LT (1) LT1539766T (no)
MX (1) MXPA04011960A (no)
NO (1) NO332691B1 (no)
NZ (1) NZ537315A (no)
PL (1) PL374017A1 (no)
PT (1) PT1539766T (no)
RS (1) RS52552B (no)
TW (1) TWI308151B (no)
WO (1) WO2003104236A1 (no)

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