ECSP11010841A - [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos - Google Patents

[4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos

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Publication number
ECSP11010841A
ECSP11010841A EC2011010841A ECSP11010841A ECSP11010841A EC SP11010841 A ECSP11010841 A EC SP11010841A EC 2011010841 A EC2011010841 A EC 2011010841A EC SP11010841 A ECSP11010841 A EC SP11010841A EC SP11010841 A ECSP11010841 A EC SP11010841A
Authority
EC
Ecuador
Prior art keywords
fluoro
inhibitor
mastocyt
trifluorometoxi
triptase
Prior art date
Application number
EC2011010841A
Other languages
English (en)
Inventor
Adam W Sledeski
Yong Mi Choi-Sledeski
Gregory Bernard Poli
John J Shay Jr
Patrick Wai-Kwok Shum
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ECSP11010841A publication Critical patent/ECSP11010841A/es

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de indol bencilamina útil como un inhibidor de triptasa. Además, la presente invención se refiere al uso del compuesto para tratar a un paciente que padece, o es propenso a padecer, una afección fisiológica que necesita mejorarse por la inhibición de triptasa, que comprende administrar al paciente una cantidad terapéuticamente eficaz del compuesto.Además, la presente invención se refiere a una composición farmacéutica que comprende una cantidad farmacéuticamente eficaz del compuesto de fórmula I, y un vehículo farmacéuticamente aceptable.
EC2011010841A 2008-08-22 2011-02-21 [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos ECSP11010841A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9101808P 2008-08-22 2008-08-22
US9101108P 2008-08-22 2008-08-22

Publications (1)

Publication Number Publication Date
ECSP11010841A true ECSP11010841A (es) 2011-03-31

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EC2011010841A ECSP11010841A (es) 2008-08-22 2011-02-21 [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos

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US (2) US8217178B2 (es)
EP (1) EP2367812B1 (es)
JP (1) JP5656834B2 (es)
KR (1) KR101630217B1 (es)
CN (2) CN102149705B (es)
AR (1) AR073117A1 (es)
AU (1) AU2009282884B8 (es)
BR (1) BRPI0916920A2 (es)
CA (1) CA2734877C (es)
CL (1) CL2009001759A1 (es)
CO (1) CO6341624A2 (es)
CR (1) CR20110093A (es)
CY (1) CY1117261T1 (es)
DK (1) DK2367812T3 (es)
DO (1) DOP2011000055A (es)
EC (1) ECSP11010841A (es)
ES (1) ES2556764T3 (es)
HK (1) HK1156598A1 (es)
HR (1) HRP20151338T1 (es)
HU (1) HUE026331T2 (es)
IL (2) IL211265A (es)
MA (1) MA32639B1 (es)
MX (1) MX2011001135A (es)
MY (1) MY150599A (es)
NI (1) NI201100024A (es)
NZ (1) NZ591234A (es)
PE (1) PE20100235A1 (es)
PL (1) PL2367812T3 (es)
PT (1) PT2367812E (es)
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RU (1) RU2509766C2 (es)
SI (1) SI2367812T1 (es)
TW (1) TWI473613B (es)
UA (1) UA104148C2 (es)
UY (1) UY32069A (es)
WO (1) WO2010022196A2 (es)
ZA (1) ZA201100597B (es)

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JP5656834B2 (ja) 2008-08-22 2015-01-21 サノフイ 肥満細胞トリプターゼインヒビターとしての［４−（５−アミノメチル−２−フルオロ−フェニル）−ピペリジン−１−イル］−［７−フルオロ−１−（２−メトキシ−エチル）−４−トリフルオロメトキシ−１ｈ−インドール−３−イル］−メタノン
FR2955324A1 (fr) * 2010-01-15 2011-07-22 Sanofi Aventis [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
JP2013515724A (ja) * 2009-12-23 2013-05-09 サノフイ ベータ−トリプターゼ阻害剤としてのトロピノンベンジルアミン類
KR20120106824A (ko) * 2009-12-23 2012-09-26 사노피 ［4［4?（5?아미노메틸?2?플루오로-페닐）?피페리딘?1?일］?（1ｈ?피롤로?피리딘?일）?메탄온들의 전구약물들 및 이들의 합성
MX2012006741A (es) * 2009-12-23 2012-07-04 Sanofi Sa Tratamiento para la enfermedad inflamatoria del intestino.
AR079662A1 (es) * 2009-12-23 2012-02-08 Sanofi Aventis Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa
WO2011106334A1 (en) * 2010-02-24 2011-09-01 Sanofi Treatment of dermatological allergic conditions
EP2397074B1 (en) 2010-06-19 2012-10-24 M Stenqvist AB A system and computer readable medium for determination of transpulmonary pressure in a patient connected to a breathing apparatus
UA115133C2 (uk) 2011-10-07 2017-09-25 Такеда Фармасьютікал Компані Лімітед Сполуки 1-арилкарбоніл-4-оксипіперидину, придатні для лікування нейродегенеративних захворювань
DE102020120900A1 (de) * 2020-08-07 2022-02-10 Drägerwerk AG & Co. KGaA Vorrichtung und Verfahren zur Messung der Lungen-Compliance

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