UA104148C2 - [4-(5-аминометил-2-фторфенил)-пиперидин-1-ил]-[7-фтор-1-(2-метоксиэтил)-4-трифторметокси-1h-индол-3-ил]-метанон как ингибитор триптазы тучных клеток - Google Patents

[4-(5-аминометил-2-фторфенил)-пиперидин-1-ил]-[7-фтор-1-(2-метоксиэтил)-4-трифторметокси-1h-индол-3-ил]-метанон как ингибитор триптазы тучных клеток

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Publication number
UA104148C2
UA104148C2 UAA201103383A UAA201103383A UA104148C2 UA 104148 C2 UA104148 C2 UA 104148C2 UA A201103383 A UAA201103383 A UA A201103383A UA A201103383 A UAA201103383 A UA A201103383A UA 104148 C2 UA104148 C2 UA 104148C2
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UA
Ukraine
Prior art keywords
fluoro
inhibitor
methanone
indol
piperidin
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UAA201103383A
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English (en)
Ukrainian (uk)
Inventor
Йонг Мі Чоі-Следескі
Накієн Чой
Грегорі Бернард Полі
мол. Шей Джон Дж.
Патрік Ваі-Квок Шум
Адам В. Следескі
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Санофі-Авентіс
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Publication of UA104148C2 publication Critical patent/UA104148C2/ru

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Данное изобретение касается индолбензиламинового соединения, которое используется как ингибитор триптазы. Данное изобретение также касается применения соединения для лечения пациента, который находится в таком физиологическом состоянии или подвержен такому физиологическому состоянию, которое необходимо улучшить путем угнетения триптазы, и состоит во введении пациенту терапевтически эффективного количества соединения. Кроме того, данное изобретение касается лекарственного препарата, который содержит фармацевтически эффективное количество соединения формулы I и фармацевтически приемлемый носитель.
UAA201103383A 2008-08-22 2009-08-20 [4-(5-аминометил-2-фторфенил)-пиперидин-1-ил]-[7-фтор-1-(2-метоксиэтил)-4-трифторметокси-1h-индол-3-ил]-метанон как ингибитор триптазы тучных клеток UA104148C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9101808P 2008-08-22 2008-08-22
US9101108P 2008-08-22 2008-08-22
PCT/US2009/054381 WO2010022196A2 (en) 2008-08-22 2009-08-20 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1h-indol-3-yl]-methanone as an inhibitor of mast cell tryptase

Publications (1)

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UA104148C2 true UA104148C2 (ru) 2014-01-10

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UAA201103383A UA104148C2 (ru) 2008-08-22 2009-08-20 [4-(5-аминометил-2-фторфенил)-пиперидин-1-ил]-[7-фтор-1-(2-метоксиэтил)-4-трифторметокси-1h-индол-3-ил]-метанон как ингибитор триптазы тучных клеток

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US (2) US8217178B2 (ru)
EP (1) EP2367812B1 (ru)
JP (1) JP5656834B2 (ru)
KR (1) KR101630217B1 (ru)
CN (2) CN102149705B (ru)
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AU (1) AU2009282884B8 (ru)
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UA (1) UA104148C2 (ru)
UY (1) UY32069A (ru)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2367812E (pt) 2008-08-22 2016-01-20 Sanofi Sa [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]metanona como um inibidor da triptase de mastócitos
FR2955324A1 (fr) * 2010-01-15 2011-07-22 Sanofi Aventis [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
EP2516428A1 (en) * 2009-12-23 2012-10-31 Sanofi Tropinone benzylamines as beta-tryptase inhibitors
RS53456B (en) * 2009-12-23 2014-12-31 Sanofi [4 [4- (5-AMINOMETHYL-2-FLUOR-PHENYL) -PIPERIDIN-1-IL] - (1H-Pyrrolo-pyridin-IL) -METHANONE AND THEIR SYNTHESIS
MX2012006805A (es) * 2009-12-23 2012-07-10 Sanofi Sa Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa.
CA2785434A1 (en) * 2009-12-23 2011-06-30 Sanofi Treatment for inflammatory bowel disease
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