PT2367812E - [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]metanona como um inibidor da triptase de mastócitos - Google Patents

[4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]metanona como um inibidor da triptase de mastócitos Download PDF

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Publication number
PT2367812E
PT2367812E PT97916936T PT09791693T PT2367812E PT 2367812 E PT2367812 E PT 2367812E PT 97916936 T PT97916936 T PT 97916936T PT 09791693 T PT09791693 T PT 09791693T PT 2367812 E PT2367812 E PT 2367812E
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PT
Portugal
Prior art keywords
fluoro
methanone
indol
piperidin
aminomethyl
Prior art date
Application number
PT97916936T
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English (en)
Inventor
Yong-Mi Choi-Sledeski
Nakyen Choy
Gregory Bernard Poli
John J Shay Jr
Patrick Wai-Kwok Shum
Adam W Sledeski
Original Assignee
Sanofi Sa
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Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PT2367812E publication Critical patent/PT2367812E/pt

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61P27/00Drugs for disorders of the senses
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    • A61P27/14Decongestants or antiallergics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12Antivirals
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    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
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    • C07D209/04Indoles; Hydrogenated indoles
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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PT97916936T 2008-08-22 2009-08-20 [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]metanona como um inibidor da triptase de mastócitos PT2367812E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9101108P 2008-08-22 2008-08-22
US9101808P 2008-08-22 2008-08-22

Publications (1)

Publication Number Publication Date
PT2367812E true PT2367812E (pt) 2016-01-20

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PT97916936T PT2367812E (pt) 2008-08-22 2009-08-20 [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]metanona como um inibidor da triptase de mastócitos

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US (2) US8217178B2 (pt)
EP (1) EP2367812B1 (pt)
JP (1) JP5656834B2 (pt)
KR (1) KR101630217B1 (pt)
CN (2) CN103508936A (pt)
AR (1) AR073117A1 (pt)
AU (1) AU2009282884B8 (pt)
BR (1) BRPI0916920A2 (pt)
CA (1) CA2734877C (pt)
CL (1) CL2009001759A1 (pt)
CO (1) CO6341624A2 (pt)
CR (1) CR20110093A (pt)
CY (1) CY1117261T1 (pt)
DK (1) DK2367812T3 (pt)
DO (1) DOP2011000055A (pt)
EC (1) ECSP11010841A (pt)
ES (1) ES2556764T3 (pt)
HK (1) HK1156598A1 (pt)
HR (1) HRP20151338T1 (pt)
HU (1) HUE026331T2 (pt)
IL (2) IL211265A (pt)
MA (1) MA32639B1 (pt)
MX (1) MX2011001135A (pt)
MY (1) MY150599A (pt)
NI (1) NI201100024A (pt)
NZ (1) NZ591234A (pt)
PE (1) PE20100235A1 (pt)
PL (1) PL2367812T3 (pt)
PT (1) PT2367812E (pt)
RS (1) RS54413B1 (pt)
RU (1) RU2509766C2 (pt)
SI (1) SI2367812T1 (pt)
TW (1) TWI473613B (pt)
UA (1) UA104148C2 (pt)
UY (1) UY32069A (pt)
WO (1) WO2010022196A2 (pt)
ZA (1) ZA201100597B (pt)

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PE20100235A1 (es) 2008-08-22 2010-03-29 Sanofi Aventis [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos
FR2955324A1 (fr) * 2010-01-15 2011-07-22 Sanofi Aventis [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
EP2516428A1 (en) * 2009-12-23 2012-10-31 Sanofi Tropinone benzylamines as beta-tryptase inhibitors
WO2011079095A1 (en) 2009-12-23 2011-06-30 Sanofi Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
RU2012131327A (ru) * 2009-12-23 2014-02-10 Санофи Лечение воспалительного заболевания кишечника
RU2012131341A (ru) * 2009-12-23 2014-01-27 Санофи Индол-пиперидинилбензиламины как ингибиторы бета-триптазы
SG183342A1 (en) * 2010-02-24 2012-09-27 Sanofi Sa Treatment of dermatological allergic conditions
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ES2716531T3 (es) 2011-10-07 2019-06-13 Takeda Pharmaceuticals Co Compuestos de 1-arilcarbonil-4-oxi-piperidina útiles para el tratamiento de enfermedades neurodegenerativas

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US8497379B2 (en) 2013-07-30
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