PE20080944A1 - Derivados de pirimidina como inhibidores del receptor de cinasa activina(alk-5) - Google Patents

Derivados de pirimidina como inhibidores del receptor de cinasa activina(alk-5)

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Publication number
PE20080944A1
PE20080944A1 PE2007000907A PE2007000907A PE20080944A1 PE 20080944 A1 PE20080944 A1 PE 20080944A1 PE 2007000907 A PE2007000907 A PE 2007000907A PE 2007000907 A PE2007000907 A PE 2007000907A PE 20080944 A1 PE20080944 A1 PE 20080944A1
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PE
Peru
Prior art keywords
pyridin
alk
pyrimidine derivatives
kinase receptor
receptor inhibitors
Prior art date
Application number
PE2007000907A
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English (en)
Inventor
Catherine Leblanc
Maude Nadine Pierrette Pipet
Robin Alec Fairhurst
Claire Adcock
Robert Alexander Pulz
Nikolaus Johannes Stiefl
Duncan Shaw
Original Assignee
Novartis Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38515726&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080944(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06117227A external-priority patent/EP1878733A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20080944A1 publication Critical patent/PE20080944A1/es

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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Abstract

SE REFIERE A DERIVADOS DE PIRIMIDINA DE FORMULA (I), EN DONDE T1 ES UN GRUPO HETEROCICLICO DE 4 A 14 MIEMBROS SUSTITUIDO O NO SUSTITUIDO; T2 ES UN GRUPO HETEROCICLICO DE 4 A 14 MIEMBROS SUSTITUIDO O NO; Ra Y Rb SON H, ALQUILO(C1-C8), CICLOALQUILO(C3-C10); ENTRE OTROS. SON PREFERIDOS: (1H-INDOL-4-IL-METIL)-(6-PIRIDIN-3-IL-2-PIRIDIN-2-IL-PIRIMIDIN-4-IL)-AMINA; [2-(1H-INDOL-4-IL)-ETIL]-(6-PIRIDIN-3-IL-2-PIRIDIN-2-IL-PIRIMIDIN-4-IL)-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE CINASA ACTIVINA(ALK-5) Y POR LO CUAL SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS U OBSTRUCTIVAS DE LAS VIAS RESPIRATORIAS, HIPERTENSION PULMONAR, FIBROSIS PULMONAR
PE2007000907A 2006-07-14 2007-07-13 Derivados de pirimidina como inhibidores del receptor de cinasa activina(alk-5) PE20080944A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117227A EP1878733A1 (en) 2006-07-14 2006-07-14 Pyrimidine derivatives as ALK-5 inhibitors
EP06119564 2006-08-25

Publications (1)

Publication Number Publication Date
PE20080944A1 true PE20080944A1 (es) 2008-09-02

Family

ID=38515726

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000907A PE20080944A1 (es) 2006-07-14 2007-07-13 Derivados de pirimidina como inhibidores del receptor de cinasa activina(alk-5)

Country Status (17)

Country Link
US (1) US7989458B2 (es)
EP (1) EP2044056B1 (es)
JP (1) JP4960450B2 (es)
KR (1) KR101172936B1 (es)
AR (1) AR061974A1 (es)
AU (1) AU2007271964B2 (es)
BR (1) BRPI0714409A2 (es)
CA (1) CA2657227A1 (es)
CL (1) CL2007002043A1 (es)
ES (1) ES2393932T3 (es)
MX (1) MX2009000310A (es)
PE (1) PE20080944A1 (es)
PL (1) PL2044056T3 (es)
PT (1) PT2044056E (es)
RU (1) RU2485115C2 (es)
TW (1) TW200821297A (es)
WO (1) WO2008006583A1 (es)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2900801T3 (es) 2004-12-22 2022-03-18 Nitto Denko Corp Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
JP2009221164A (ja) * 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
CA2632968A1 (en) 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
GB0625659D0 (en) 2006-12-21 2007-01-31 Cancer Rec Tech Ltd Therapeutic compounds and their use
CA2703996A1 (en) * 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
BRPI0906798A2 (pt) 2008-01-09 2015-07-14 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
PL2231642T3 (pl) 2008-01-11 2014-04-30 Novartis Ag Pirymidyny jako inhibitory kinazy
RU2010139426A (ru) 2008-03-17 2012-04-27 Зе Скрипс Ресеч Инститьют (Us) Комбинация химического и генетического подходов к получению индуцированных плюрипотентных стволовых клеток
EP2285380A4 (en) * 2008-05-30 2012-03-14 Summa Health Systems Llc METHODS OF USING TGF-B RECEPTOR INHIBITORS OR ACTIVE KINASE (ALK) A-83-01 AND SB-431542 INHIBITORS TO TREAT EYE DISEASE AND INJURY HEALING
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010065917A1 (en) 2008-12-05 2010-06-10 The Regents Of The University Of California Methods of treating neurological disorders
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
WO2010098866A1 (en) 2009-02-27 2010-09-02 Supergen, Inc. Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors
WO2011044501A2 (en) 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
EP2488025A4 (en) 2009-10-15 2013-04-03 Childrens Medical Center SEPIAPTERIC INTREDUCTASE INHIBITION FOR PAIN TREATMENT
CN113621576A (zh) 2009-10-16 2021-11-09 斯克里普斯研究所 多能细胞的诱导
ES2893699T3 (es) 2010-03-31 2022-02-09 Scripps Research Inst Reprogramación de células
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
US9376664B2 (en) 2010-06-14 2016-06-28 The Scripps Research Institute Reprogramming of cells to a new fate
CN103003416B (zh) 2010-06-15 2016-11-16 细胞动力学国际有限公司 从小体积的外周血产生诱导性多潜能干细胞
CA2806858C (en) 2010-08-04 2021-06-15 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
EP2640735A1 (en) 2010-11-17 2013-09-25 Achaogen, Inc. Antibacterial amiinoglycoside analogs
KR102160721B1 (ko) 2010-12-22 2020-09-29 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
US20130040302A1 (en) 2011-07-11 2013-02-14 Thomas J. Burke Methods for cell reprogramming and genome engineering
SG11201400310WA (en) 2011-08-29 2014-06-27 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
RS58043B1 (sr) 2012-04-24 2019-02-28 Vertex Pharma Inhibitori dna-pk
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
AU2013326867B2 (en) 2012-10-05 2018-03-08 Rigel Pharmaceuticals, Inc. GDF-8 inhibitors
EP3527563B1 (en) 2013-03-12 2021-09-01 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
EP2970311A4 (en) 2013-03-14 2016-11-23 Brigham & Womens Hospital BMP INHIBITORS AND METHODS OF USE
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP2981605B1 (en) 2013-04-03 2019-06-19 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
EP2989198A4 (en) 2013-04-26 2016-10-26 Sloan Kettering Inst Cancer CORTICAL INTERNEURONES AND OTHER NEURONAL CELLS PRODUCED BY DIRECTED DIFFERENTIATION OF PLURIPOTENT AND MULTIPOTENT CELLS
CN107935988A (zh) 2013-10-14 2018-04-20 卫材R&D管理有限公司 选择性取代的喹啉化合物
TWI702218B (zh) 2013-10-14 2020-08-21 日商衛材R&D企管股份有限公司 選擇性經取代之喹啉化合物
SG11201602962PA (en) 2013-10-17 2016-05-30 Vertex Pharma Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
KR102670874B1 (ko) 2014-03-04 2024-05-31 페이트 세러퓨틱스, 인코포레이티드 개선된 재프로그래밍 방법 및 세포 배양 플랫폼
EP3122355A4 (en) * 2014-03-26 2017-08-09 The Brigham and Women's Hospital, Inc. Compositions and methods for inhibiting bmp
BR112016023967A2 (pt) 2014-04-24 2017-08-15 Novartis Ag derivados de pirazina como inibidores de fosfatidilinositol 3-cinase
EP3134397A1 (en) 2014-04-24 2017-03-01 Novartis AG Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
MX2016013981A (es) 2014-04-24 2016-11-15 Novartis Ag Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa.
US10023879B2 (en) 2014-06-04 2018-07-17 Fate Therapeutics, Inc. Minimal volume reprogramming of mononuclear cells
US10513521B2 (en) 2014-07-15 2019-12-24 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting BMP
CN114058582A (zh) 2015-01-26 2022-02-18 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
CN108291237B (zh) 2015-10-16 2023-11-21 菲特治疗公司 用于诱导和维护基态多能性的平台
CN108271369A (zh) 2015-10-23 2018-07-10 法尔玛赞公司 用于制备色胺及其衍生物的新工艺
CA3003145A1 (en) 2015-10-30 2017-05-04 Gay M. Crooks Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
WO2017079673A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
CN115927199A (zh) 2015-11-04 2023-04-07 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
CR20180323A (es) * 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
JP2019502725A (ja) 2016-01-20 2019-01-31 フェイト セラピューティクス，インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
RU2758669C2 (ru) 2016-09-27 2021-11-01 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк
US11932870B2 (en) 2016-12-05 2024-03-19 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CR20190559A (es) 2017-05-18 2020-02-10 Idorsia Pharmaceuticals Ltd Derivados de fenilo como moduladores del receptor de pge2
LT3625228T (lt) 2017-05-18 2021-10-25 Idorsia Pharmaceuticals Ltd Pirimidino dariniai, kaip pge2 receptoriaus moduliatoriai
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
AR111874A1 (es) 2017-05-18 2019-08-28 Idorsia Pharmaceuticals Ltd Derivados de pirimidina
EP3651747A4 (en) 2017-11-17 2020-07-22 Cellix Bio Private Limited COMPOSITIONS AND METHODS OF TREATMENT OF EYE DISORDERS
US11919902B2 (en) * 2017-12-22 2024-03-05 Hibercell, Inc. Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors
CN111867632A (zh) * 2018-03-23 2020-10-30 赛途公司 骨骼肌肥大诱导剂的alk5抑制剂
AU2021237646B2 (en) * 2020-03-19 2023-05-11 Caamtech, Inc. Crystalline norpsilocin compounds
TW202204339A (zh) * 2020-03-31 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 經取代的嘧啶及使用方法
TW202210472A (zh) 2020-06-05 2022-03-16 美商奇奈特生物製藥公司 纖維母細胞生長因子受體激酶之抑制劑
EP4182322B1 (en) 2020-07-15 2024-04-24 Chiesi Farmaceutici S.p.A. Pyrido oxazine derivatives as alk5 inhibitors
US20240190891A1 (en) 2020-07-15 2024-06-13 Chiesi Farmaceutici S.P.A. Pyrido oxazine amino derivatives as alk5 inhibitors
JP2023533849A (ja) 2020-07-15 2023-08-04 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ａｌｋ５阻害剤としてのピリダジニルアミノ誘導体
US20240116948A1 (en) 2020-12-23 2024-04-11 Chiesi Farmaceutici S.P.A. Pyrido oxazine derivatives as alk5 inhibitors
WO2023046698A1 (en) 2021-09-21 2023-03-30 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors
WO2023208986A1 (en) 2022-04-27 2023-11-02 Chiesi Farmaceutici S.P.A. Imidazole derivatives as alk5 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345640A (en) * 1971-02-01 1974-01-30 Shell Int Research Piperazinyl pyrimidines
JP4495257B2 (ja) * 1997-02-19 2010-06-30 バーレツクス ラボラトリーズ インコーポレーテツド Ｎｏｓ抑制剤としてのｎ−複素環誘導体
AU740813B2 (en) * 1998-07-08 2001-11-15 Monash University Pharmaceutical agents
WO2001047897A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Cytokine, especially tnf-alpha, inhibitors
EP1351691A4 (en) * 2000-12-12 2005-06-22 Cytovia Inc SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF
GB0102665D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
KR20050013562A (ko) * 2002-05-30 2005-02-04 버텍스 파마슈티칼스 인코포레이티드 Ｊａｋ 및 ｃｄｋ2 프로테인 키나아제의 억제제
GB0217786D0 (en) * 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
JP2005539000A (ja) * 2002-07-31 2005-12-22 スミスクライン・ビーチャム・コーポレイション Ａｌｋ５阻害剤としての２−フェニルピリジン−４−イル誘導体
WO2004065392A1 (en) 2003-01-24 2004-08-05 Smithkline Beecham Corporation Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands
GB0313915D0 (en) 2003-06-16 2003-07-23 Smithkline Beecham Corp Compounds
CN1820001A (zh) * 2003-07-10 2006-08-16 神经能质公司 经取代的杂环二芳基胺类似物
WO2005028467A1 (en) * 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
WO2005058883A1 (en) * 2003-12-15 2005-06-30 Almirall Prodesfarma Ag 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
GB0520657D0 (en) * 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds

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