CR20190559A - Derivados de fenilo como moduladores del receptor de pge2 - Google Patents

Derivados de fenilo como moduladores del receptor de pge2

Info

Publication number
CR20190559A
CR20190559A CR20190559A CR20190559A CR20190559A CR 20190559 A CR20190559 A CR 20190559A CR 20190559 A CR20190559 A CR 20190559A CR 20190559 A CR20190559 A CR 20190559A CR 20190559 A CR20190559 A CR 20190559A
Authority
CR
Costa Rica
Prior art keywords
formula
phenyl derivatives
receptor modulators
pge2 receptor
pharmaceuticals
Prior art date
Application number
CR20190559A
Other languages
English (en)
Inventor
Heinz Fretz
Davide Pozzi
Isabelle Lyothier
Sylvia Richard-Bildstein
Thierry Sifferlen
Christoph Boss
Hervé Siendt
Olivier Corminboeuf
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CR20190559A publication Critical patent/CR20190559A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente invención se refiere a derivados de fenilo de fórmula (I) donde (R1)n, R3, R4a, R4b, R5a, R5b y Ar1 son como se describen en la descripción y su uso en el tratamiento del cáncer mediante la modulación de una respuesta inmune que comprende una reactivación del sistema inmune en el tumor. La invención se refiere además a nuevos derivados de benzofurano y benzotiofeno de fórmula (III) y su uso como productos farmacéuticos, a su preparación, a las sales aceptables para uso farmacéuticos de los mismos, y a su uso como productos farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de fórmula (I), y especialmente a su uso como moduladores de los receptores EP2 y/o EP4 de la prostaglandina 2.
CR20190559A 2017-05-18 2018-05-17 Derivados de fenilo como moduladores del receptor de pge2 CR20190559A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017062031 2017-05-18
PCT/EP2018/062862 WO2018210994A1 (en) 2017-05-18 2018-05-17 Phenyl derivatives as pge2 receptor modulators

Publications (1)

Publication Number Publication Date
CR20190559A true CR20190559A (es) 2020-02-10

Family

ID=62186480

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190559A CR20190559A (es) 2017-05-18 2018-05-17 Derivados de fenilo como moduladores del receptor de pge2

Country Status (32)

Country Link
US (1) US11712438B2 (es)
EP (1) EP3625222B1 (es)
JP (1) JP7159214B2 (es)
KR (1) KR102632028B1 (es)
CN (1) CN110612296A (es)
AR (1) AR111941A1 (es)
AU (1) AU2018269666B2 (es)
BR (1) BR112019024109A2 (es)
CA (1) CA3060597A1 (es)
CL (1) CL2019003275A1 (es)
CO (1) CO2019010578A2 (es)
CR (1) CR20190559A (es)
CY (1) CY1124608T1 (es)
DK (1) DK3625222T3 (es)
EA (1) EA201992676A1 (es)
ES (1) ES2893452T3 (es)
HR (1) HRP20211533T1 (es)
HU (1) HUE056080T2 (es)
IL (1) IL270623B2 (es)
LT (1) LT3625222T (es)
MA (1) MA49126B1 (es)
MX (1) MX2019013718A (es)
PE (1) PE20191814A1 (es)
PH (1) PH12019502563A1 (es)
PL (1) PL3625222T3 (es)
PT (1) PT3625222T (es)
RS (1) RS62440B1 (es)
SG (1) SG11201908729UA (es)
SI (1) SI3625222T1 (es)
TW (1) TWI765041B (es)
UA (1) UA125123C2 (es)
WO (1) WO2018210994A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
KR102626982B1 (ko) 2017-05-18 2024-01-18 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 피리미딘 유도체
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
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PE20191814A1 (es) 2019-12-27
AU2018269666B2 (en) 2022-02-03
DK3625222T3 (da) 2021-10-25
MX2019013718A (es) 2020-01-30
CN110612296A (zh) 2019-12-24
US11712438B2 (en) 2023-08-01
JP2020520356A (ja) 2020-07-09
EP3625222B1 (en) 2021-07-21
EP3625222A1 (en) 2020-03-25
MA49126B1 (fr) 2021-10-29
PL3625222T3 (pl) 2021-12-27
TWI765041B (zh) 2022-05-21
IL270623A (es) 2019-12-31
TW201900175A (zh) 2019-01-01
CO2019010578A2 (es) 2019-10-09
PH12019502563A1 (en) 2020-07-20
SG11201908729UA (en) 2019-10-30
BR112019024109A2 (pt) 2020-06-02
LT3625222T (lt) 2021-11-10
AR111941A1 (es) 2019-09-04
CL2019003275A1 (es) 2020-05-04
HUE056080T2 (hu) 2022-01-28
ES2893452T3 (es) 2022-02-09
US20200179383A1 (en) 2020-06-11
HRP20211533T1 (hr) 2022-01-07
MA49126A (fr) 2020-03-25
PT3625222T (pt) 2021-10-07
SI3625222T1 (sl) 2021-11-30
EA201992676A1 (ru) 2020-05-06
RS62440B1 (sr) 2021-11-30
JP7159214B2 (ja) 2022-10-24
WO2018210994A1 (en) 2018-11-22
KR20200010352A (ko) 2020-01-30
AU2018269666A1 (en) 2020-01-16
IL270623B (en) 2022-11-01
IL270623B2 (en) 2023-03-01
CY1124608T1 (el) 2022-07-22
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CA3060597A1 (en) 2018-11-22
UA125123C2 (uk) 2022-01-12

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