GB1345640A - Piperazinyl pyrimidines - Google Patents
Piperazinyl pyrimidinesInfo
- Publication number
- GB1345640A GB1345640A GB442172A GB442172A GB1345640A GB 1345640 A GB1345640 A GB 1345640A GB 442172 A GB442172 A GB 442172A GB 442172 A GB442172 A GB 442172A GB 1345640 A GB1345640 A GB 1345640A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrimidines
- chloro
- moieties
- dichloro
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1345640 Pyrimidines SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ NV 31 Jan 1972 [1 Feb 1971] 4421/72 Heading C2C Novel compounds of Formula I wherein R represents morpholine, monoalkylamine of up to 6 carbon atoms or cycloalkylamine of up to 6 carbon atoms; R<SP>1</SP> is any of the moieties represented by R or is piperazine; or their acid addition salts and hydrates are prepared by a selected stepwise replacement of the chlorine moieties of 2,4,6-trichloropyrimidine with the 2- and 4-chloro substituents being replaced first by the selected amino moieties as defined by R and R<SP>1</SP> above and then the 6-chloro substituent then being replaced by a piperazino moiety. Intermediate 6 - chloro - R - R<SP>1</SP> - pyrimidines, 2,6-dichloro - 4 - R - pyrimidines, and 4,6-dichloro-R-pyrimidines are isolated. Pharmaceutical compositions in conventional forms for oral, rectal and parenteral administration and having anti-inflammatory activity comprise an above novel compound and a suitable adjuvant.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11163571A | 1971-02-01 | 1971-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1345640A true GB1345640A (en) | 1974-01-30 |
Family
ID=22339605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB442172A Expired GB1345640A (en) | 1971-02-01 | 1972-01-31 | Piperazinyl pyrimidines |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1345640A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987001706A2 (en) * | 1985-09-12 | 1987-03-26 | The Upjohn Company | C20 through c26 amino steroids |
AU614661B2 (en) * | 1985-09-12 | 1991-09-05 | Pharmacia & Upjohn Company | Amines useful in the preparation of c20 through c26 amine steroids |
US5380839A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Phenylpiperazinyl steroids |
US5550240A (en) * | 1992-06-09 | 1996-08-27 | Richter Gedeon Vegyeszeti Gyar Rt. | Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same |
JP2009543765A (en) * | 2006-07-14 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | Pyrimidine derivatives as ALK-5 inhibitors |
US20100298143A1 (en) * | 2009-05-19 | 2010-11-25 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
-
1972
- 1972-01-31 GB GB442172A patent/GB1345640A/en not_active Expired
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987001706A2 (en) * | 1985-09-12 | 1987-03-26 | The Upjohn Company | C20 through c26 amino steroids |
WO1987001706A3 (en) * | 1985-09-12 | 1987-07-16 | Upjohn Co | C20 through c26 amino steroids |
AU614661B2 (en) * | 1985-09-12 | 1991-09-05 | Pharmacia & Upjohn Company | Amines useful in the preparation of c20 through c26 amine steroids |
US5380839A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Phenylpiperazinyl steroids |
US5380840A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Triazinylpiperazinyl steroids |
US5380841A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Pyridinylpiperazinyl steroids |
US5382661A (en) * | 1985-09-12 | 1995-01-17 | The Upjohn Company | Pyrazinylpiperazinyl steroids |
US5506354A (en) * | 1985-09-12 | 1996-04-09 | The Upjohn Company | Imidazolylpiperazinyl steroids |
US5550240A (en) * | 1992-06-09 | 1996-08-27 | Richter Gedeon Vegyeszeti Gyar Rt. | Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same |
JP2009543765A (en) * | 2006-07-14 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | Pyrimidine derivatives as ALK-5 inhibitors |
US20100298143A1 (en) * | 2009-05-19 | 2010-11-25 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
JP2012527461A (en) * | 2009-05-19 | 2012-11-08 | ダウ アグロサイエンシィズ エルエルシー | Compounds and methods for controlling fungi |
US8759356B2 (en) * | 2009-05-19 | 2014-06-24 | Dow Agrosciences, Llc. | Compounds and methods for controlling fungi |
AU2010250017B2 (en) * | 2009-05-19 | 2015-02-12 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |