EA201400392A1 - ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb - Google Patents

ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb

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Publication number
EA201400392A1
EA201400392A1 EA201400392A EA201400392A EA201400392A1 EA 201400392 A1 EA201400392 A1 EA 201400392A1 EA 201400392 A EA201400392 A EA 201400392A EA 201400392 A EA201400392 A EA 201400392A EA 201400392 A1 EA201400392 A1 EA 201400392A1
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Eurasian Patent Office
Prior art keywords
rev
erb
substituted
agonists
triazolopiridazines
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EA201400392A
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English (en)
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EA029834B1 (ru
Inventor
Мерилин Буротт
Жан-Франсуа Дельомель
Матьё Дюберне
Мари-Элен Гуй
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Жанфит
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Publication of EA201400392A1 publication Critical patent/EA201400392A1/ru
Publication of EA029834B1 publication Critical patent/EA029834B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Изобретение относится к новым 6-замещенным 1,2,4-триазоло[4,3-b]пиридазинам, которые являются агонистами Rev-Erb. Такие соединения и фармацевтические композиции, включающие их, являются подходящими средствами для лечения любого заболевания, при котором активация Rev-Erb оказывает терапевтическое действие, например, при воспалительных и связанных с циркадным ритмом расстройствах или кардиометаболических заболеваниях.
EA201400392A 2011-09-27 2012-09-27 ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb EA029834B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306234 2011-09-27
EP12163795 2012-04-11
PCT/EP2012/069014 WO2013045519A1 (en) 2011-09-27 2012-09-27 Derivatives of 6-substituted triazolopyridazines as rev-erb agonists

Publications (2)

Publication Number Publication Date
EA201400392A1 true EA201400392A1 (ru) 2014-09-30
EA029834B1 EA029834B1 (ru) 2018-05-31

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EA201400392A EA029834B1 (ru) 2011-09-27 2012-09-27 ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb

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US (2) US9586963B2 (ru)
EP (1) EP2760866B1 (ru)
JP (1) JP6042438B2 (ru)
CN (1) CN104024259B (ru)
AU (1) AU2012314501B2 (ru)
BR (1) BR112014006924B1 (ru)
CA (1) CA2848518C (ru)
EA (1) EA029834B1 (ru)
HK (1) HK1200448A1 (ru)
IL (1) IL231501B (ru)
MX (1) MX356683B (ru)
WO (1) WO2013045519A1 (ru)
ZA (1) ZA201402975B (ru)

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US9872851B2 (en) * 2012-12-12 2018-01-23 The Charlotte-Mecklenburg Hospital Authority Methods of treating portal hypertension
ITTO20130816A1 (it) 2013-10-09 2015-04-10 Fond Istituto Italiano Di Tecnologia Antagonisti di rev-erb diarilalchilaminici e loro uso come farmaci
CN105596336B (zh) * 2016-01-18 2018-05-22 暨南大学 化合物sr8278在制备治疗i型糖尿病角膜病变药物中的应用
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PT3548033T (pt) 2016-11-28 2024-08-09 Praxis Prec Medicines Inc Compostos e respectivos métodos de utilização
US11389427B2 (en) 2017-02-10 2022-07-19 Case Western Reserve University Compositions and methods of treating cardiac hypertrophy and heart failure
WO2018148745A1 (en) 2017-02-13 2018-08-16 Praxis Precision Medicines , Inc. Compounds and their methods of use
WO2018187480A1 (en) 2017-04-04 2018-10-11 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11278535B2 (en) 2017-08-15 2022-03-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
MX2020005818A (es) * 2017-12-19 2020-08-20 Bristol Myers Squibb Co Triazol azoles de acido ciclohexilo como antagonistas de acido lisofosfatidico (lpa).
BR112020024379A2 (pt) 2018-05-30 2021-03-02 Praxis Precision Medicines, Inc. moduladores de canais iônicos
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
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MX356683B (es) 2018-06-08
HK1200448A1 (en) 2015-08-07
EP2760866B1 (en) 2017-12-13
ZA201402975B (en) 2015-04-29
US20170296548A1 (en) 2017-10-19
JP6042438B2 (ja) 2016-12-14
MX2014003637A (es) 2014-09-22
CA2848518A1 (en) 2013-04-04
BR112014006924B1 (pt) 2020-10-06
AU2012314501A1 (en) 2014-05-15
US9586963B2 (en) 2017-03-07
IL231501B (en) 2018-05-31
JP2014527996A (ja) 2014-10-23
US10799510B2 (en) 2020-10-13
BR112014006924A2 (pt) 2017-04-11
US20150038503A1 (en) 2015-02-05
EP2760866A1 (en) 2014-08-06
IL231501A0 (en) 2014-05-28
CA2848518C (en) 2019-06-18
AU2012314501B2 (en) 2017-02-16
EA029834B1 (ru) 2018-05-31
WO2013045519A1 (en) 2013-04-04
CN104024259A (zh) 2014-09-03
BR112014006924A8 (pt) 2018-01-09
CN104024259B (zh) 2017-09-26

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