AR042861A1 - Forma de presentacion para administracion por via oral, para ester etilico de acido 3-((2-((4-(hexiloxicarbonilamino-iminome-til)-fenilamino)-metil)-1-metil-1h-bencimipropionico y sus sales - Google Patents

Forma de presentacion para administracion por via oral, para ester etilico de acido 3-((2-((4-(hexiloxicarbonilamino-iminome-til)-fenilamino)-metil)-1-metil-1h-bencimipropionico y sus sales

Info

Publication number
AR042861A1
AR042861A1 ARP030100779A ARP030100779A AR042861A1 AR 042861 A1 AR042861 A1 AR 042861A1 AR P030100779 A ARP030100779 A AR P030100779A AR P030100779 A ARP030100779 A AR P030100779A AR 042861 A1 AR042861 A1 AR 042861A1
Authority
AR
Argentina
Prior art keywords
methyl
ethyl ester
possibly
pharmaceutically acceptable
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP030100779A
Other languages
English (en)
Inventor
Ulrich Brauns
Norbert Hauel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27789735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR042861(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10209985A external-priority patent/DE10209985A1/de
Priority claimed from DE2002145624 external-priority patent/DE10245624A1/de
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR042861A1 publication Critical patent/AR042861A1/es
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Presentación para administración por vía oral, para la sustancia activa éster etílico de ácido 3-[(2-{[4-(hexiloxi-carbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico y sus sales farmacológicamente tolerables. Reivindicación 1: Composición farmacéutica para administración por vía oral, que comprende al menos: a) éster etílico de ácido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico o una de sus sales farmacéuticamente aceptables, y b) uno o varios ácidos orgánicos farmacéuticamente aceptables, con una solubilidad en agua > 1 g/250 ml. a 20° C. Reivindicación 14: Procedimiento para preparar una composición farmacéutica para administración por vía oral que contiene éster etílico de ácido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico o una de sus sales fisiológicamente tolerables, que comprende los pasos de: a) elaborar el material del núcleo a partir de uno o varios ácidos orgánicos farmacéuticamente aceptables con una solubilidad en agua > 1 g/250 ml. a 20° C, eventualmente con adición de agentes aglutinantes u otras sustancias auxiliares tecnológicas, en procedimientos en bombo, en discos granuladores, o por medio de extrusión/esferonización, b) aplicar una capa aislante compuesta por uno o varios polímeros solubles en agua, farmacéuticamente aceptables, eventualmente con adición de plastificantes, agentes disgregantes y/o pigmentos sobre el material del núcleo, c) aplicar la sustancia activa desde una dispersión que contiene agente aglutinante y eventualmente agente disgregante, y secar simultánea y/o ulteriormente, para eliminar el agente dispersante, d) eventualmente aplicar un revestimiento a base de formadores de película, plastificante y eventualmente pigmentos, y e) llenar los gránulos así obtenidos, que contienen sustancia activa, en cápsulas duras.
ARP030100779A 2002-03-07 2003-03-07 Forma de presentacion para administracion por via oral, para ester etilico de acido 3-((2-((4-(hexiloxicarbonilamino-iminome-til)-fenilamino)-metil)-1-metil-1h-bencimipropionico y sus sales Pending AR042861A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10209985A DE10209985A1 (de) 2002-03-07 2002-03-07 Oral zu applizierende Darreichungsform für 3-[(2-{[4-(Hexyloxycarbonylaminoimino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propinsäure-ethylester und dessen Salze
DE2002145624 DE10245624A1 (de) 2002-09-30 2002-09-30 Oral zu applizierende Darreichungsform für 3-[(2-{[4-(Hexyloxycarbonylaminoimino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2yl-amino]-propinsäure-ethylester und dessen Salze

Publications (1)

Publication Number Publication Date
AR042861A1 true AR042861A1 (es) 2005-07-06

Family

ID=27789735

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030100779A Pending AR042861A1 (es) 2002-03-07 2003-03-07 Forma de presentacion para administracion por via oral, para ester etilico de acido 3-((2-((4-(hexiloxicarbonilamino-iminome-til)-fenilamino)-metil)-1-metil-1h-bencimipropionico y sus sales
ARP090102391A Pending AR072385A2 (es) 2002-03-07 2009-06-26 Metanosulfonato de ester etilico de acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico y composicion farmaceutica para administracion por via oral que lo contiene

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP090102391A Pending AR072385A2 (es) 2002-03-07 2009-06-26 Metanosulfonato de ester etilico de acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico y composicion farmaceutica para administracion por via oral que lo contiene

Country Status (36)

Country Link
US (2) US20190231766A1 (es)
EP (2) EP1870100B1 (es)
JP (3) JP3866715B2 (es)
KR (1) KR101005716B1 (es)
CN (1) CN100528157C (es)
AR (2) AR042861A1 (es)
AT (1) ATE540943T1 (es)
AU (1) AU2003210400B8 (es)
BR (1) BRPI0306559B8 (es)
CA (1) CA2476054C (es)
CL (1) CL2009001915A1 (es)
CO (1) CO5611149A2 (es)
CY (4) CY1112796T1 (es)
DE (1) DE122012000047I1 (es)
DK (2) DK1485094T4 (es)
EA (1) EA009664B1 (es)
EC (1) ECSP045331A (es)
ES (2) ES2380704T3 (es)
HK (1) HK1078792A1 (es)
HR (1) HRP20040807B1 (es)
IL (3) IL163863A0 (es)
LU (2) LU92025I2 (es)
ME (1) ME00325B (es)
MX (1) MXPA04008542A (es)
MY (1) MY143734A (es)
NO (3) NO326918B1 (es)
NZ (2) NZ546367A (es)
PE (1) PE20030889A1 (es)
PL (2) PL212566B1 (es)
PT (2) PT1485094E (es)
RS (1) RS52088B (es)
SG (1) SG146435A1 (es)
SI (2) SI1870100T1 (es)
TW (1) TWI293879B (es)
WO (1) WO2003074056A1 (es)
ZA (1) ZA200406071B (es)

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