AR030696A1 - Derivados de hidroxi-1-azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preparar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion - Google Patents

Derivados de hidroxi-1-azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preparar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion

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Publication number
AR030696A1
AR030696A1 ARP010102468A ARP010102468A AR030696A1 AR 030696 A1 AR030696 A1 AR 030696A1 AR P010102468 A ARP010102468 A AR P010102468A AR P010102468 A ARP010102468 A AR P010102468A AR 030696 A1 AR030696 A1 AR 030696A1
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AR
Argentina
Prior art keywords
substituted
aryl
cycloalkyl
alkyl
compounds
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ARP010102468A
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English (en)
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Smithkline Beecham Corp
Glaxo Group Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26901947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR030696(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp, Glaxo Group Ltd filed Critical Smithkline Beecham Corp
Publication of AR030696A1 publication Critical patent/AR030696A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Vehicle Body Suspensions (AREA)
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Abstract

Derivados de hidroxi-1-azobenceno y sales, hidratos, solvatos y ésteres farmacéuticamente aceptables de los mismos, que son miméticos no peptídicos de la trombopoyetina y en consecuencia son utiles como promotores de la trombopoyesis y megacariocitopoyesis. Tales derivados tienen la formula (1) en la que: R, R1, R2 y R3 se seleccionan cada uno independientemente de hidrogeno, alquilo C1-6, -(CH2)pOR4, -C(O)OR4, formilo, nitro, ciano, halogeno, arilo, arilo sustituido, alquilo sustituido, -S(O)nR4, cicloalquilo, -NR5R6, -OH protegido, -CONR5R6, ácido fosfonico, ácido sulfonico, ácido fosfínico, -SO2NR5R6, y un sustituyente metilen-heterocíclico como se representa en la formula (3) en la que p es 0-6, n es 0-2, V, W, X y Z se seleccionan cada uno independientemente de O; S y NR16, en el que R16 se selecciona de: hidrogeno, alquilo, cicloalquilo, arilo C1-12, alquilo sustituido, cicloalquilo sustituido y arilo C1-12 sustituido, R4 se selecciona de: hidrogeno, alquilo, cicloalquilo, arilo C1-12, alquilo sustituido, cicloalquilo sustituido y arilo C1-12 sustituido, y R5 y R6 se seleccionan cada uno independientemente de hidrogeno, alquilo, alquilo sustituido, cicloalquilo C3-6, y arilo, o R5 y R6 tomados junto con el átomo de nitrogeno al que están unidos representan un anillo saturado de 5 a 6 miembros que contiene hasta otro heteroátomo seleccionado de oxígeno y nitrogeno; m es 0-6; y AR es un anillo aromático cíclico o policíclico que contiene de 3 a 16 átomos y que contiene opcionalmente uno o más heteroátomos, con la condicion de que, cuando el numero de átomos de carbono es 3, el anillo aromático contiene al menos dos heteroátomos y cuando el numero de átomos de carbono es 4 el anillo aromático contiene al menos un heteroátomo, y opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consta de: alquilo, alquilo sustituido, arilo, cicloalquilo sustituido, arilo sustituido, ariloxi, oxo, hidroxi, alcoxi, cicloalquilo, aciloxi, amino, N-acilamino, nitro, ciano, halogeno, -C(O)OR4, -C(O)NR10R11, -S(O)2NR10R11, -S(O)nR4 y -OH protegido, en el que n es 0-2, R4 es hidrogeno, alquilo, cicloalquilo, arilo C1-12, alquilo sustituido, cicloalquilo sustituido y arilo C1-12 sustituido, y R10 y R11 son independientemente hidrogeno, cicloalquilo, arilo C1-12, cicloalquilo sustituido, arilo C1-12 sustituido, alquilo o alquilo sustituido con uno o más sustituyentes seleccionados del grupo que consta de: alcoxi, aciloxi, ariloxi, amino, N-acilamino, oxo, hidroxi, -C(O)OR4, -S(O)nR4, -C(O)NR4R4, -S(O)2NR4R4, nitro, ciano, cicloalquilo, cicloalquilo sustituido, halogeno, arilo, arilo sustituido y -OH protegido, o R10 y R11, tomados juntos con el átomo de nitrogeno al que están unidos, representan un anillo saturado de 5 a 6 miembros que contiene hasta otro heteroátomo seleccionado de oxígeno y nitrogeno, en el que R4 es como se describe anteriormente y n es 0-2; con la condicion de que al menos uno de R, R1, R2, y R3 sea un grupo arilo sustituido o un sustituyente metilen-heterocíclico como se representa en la formula (3) Además también se dan a conocer: composiciones farmacéuticas que los comprenden, el uso de dichos compuestos en la fabricacion de medicamentos para el tratamiento de la trombocitopenia, un proceso para preparar dichas composiciones, un proceso para preparar dichos compuestos, un método in vitro o ex vivo para aumentar la estimulacion de la maduracion de megacariocitos y/o produccion de trombocitos, un método in vitro o ex vivo para aumentar la supervivencia y/o proliferacion de células madre, células de médula osea, células de sangre del cordon umbilical, células de sangre periférica u otros tipos de células que expresan el receptor de TPO en cultivo, un método in vitro o ex vivo para aumentar la estimulacion de la produccion de neutrofilos, y un intermediario usado en la preparacion de dichos compuestos.
ARP010102468A 2000-05-25 2001-05-23 Derivados de hidroxi-1-azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preparar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion AR030696A1 (es)

Applications Claiming Priority (2)

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US20708400P 2000-05-25 2000-05-25
US22892900P 2000-08-30 2000-08-30

Publications (1)

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AR030696A1 true AR030696A1 (es) 2003-09-03

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ARP010102468A AR030696A1 (es) 2000-05-25 2001-05-23 Derivados de hidroxi-1-azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preparar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion
ARP080101867A AR066036A2 (es) 2000-05-25 2008-05-02 Derivados de hidroxi-1- azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preprar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion

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ARP080101867A AR066036A2 (es) 2000-05-25 2008-05-02 Derivados de hidroxi-1- azobenceno, composiciones farmaceuticas que los comprenden, uso de dichos compuestos en la fabricacion de medicamentos, proceso para preparar dichas composiciones, proceso para preprar dichos compuestos, metodo in vitro o ex vivo para aumentar la estimulacion de la maduracion

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US (9) US7160870B2 (es)
EP (3) EP1864981B8 (es)
JP (2) JP3813875B2 (es)
KR (2) KR100798568B1 (es)
CN (4) CN101343250B (es)
AR (2) AR030696A1 (es)
AT (2) ATE374772T1 (es)
AU (2) AU2001274938C1 (es)
BE (1) BE2010C018I2 (es)
BR (1) BRPI0111116B8 (es)
CA (1) CA2411468C (es)
CY (4) CY2010012I2 (es)
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DK (3) DK1864981T3 (es)
ES (3) ES2328179T3 (es)
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