AR014167A1 - UNA AMIDA PEPTíDICA OPIOIDE SINTÉTICA O UNA SAL FARMACÉUTICAMENTE ACEPTABLE Y COMPOSICIoN FARMACÉUTICA QUE LA CONTIENE. - Google Patents

UNA AMIDA PEPTíDICA OPIOIDE SINTÉTICA O UNA SAL FARMACÉUTICAMENTE ACEPTABLE Y COMPOSICIoN FARMACÉUTICA QUE LA CONTIENE.

Info

Publication number
AR014167A1
AR014167A1 ARP980106652A ARP980106652A AR014167A1 AR 014167 A1 AR014167 A1 AR 014167A1 AR P980106652 A ARP980106652 A AR P980106652A AR P980106652 A ARP980106652 A AR P980106652A AR 014167 A1 AR014167 A1 AR 014167A1
Authority
AR
Argentina
Prior art keywords
amid
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
composition containing
Prior art date
Application number
ARP980106652A
Other languages
English (en)
Inventor
Louis Junien Jean
J M Riviere Pierre
D Schteingart Claudio
Sueiras Diaz Javier
A Trojnar Jerzy
W Vanderah Todd
Original Assignee
Cara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc filed Critical Cara Therapeutics Inc
Publication of AR014167A1 publication Critical patent/AR014167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dichos péptidos exhiben alta selectividad por el receptor opioide Kappa (KOR) y larga duracion de accion periférica sin entrada significativa en elcerebro, éstos son secuencias de 4 residuos de aminoácidos de D-isomero que tienen un C-termina l que es una amida mono o di-sustituida. Tiene afinidad porel receptor opioide Kappa la cual es por lo menos 1000 veces la afinidad para el receptor opioide mu y exhibe larga duracion de accion cuando se administrain vivo.
ARP980106652A 1997-12-23 1998-12-23 UNA AMIDA PEPTíDICA OPIOIDE SINTÉTICA O UNA SAL FARMACÉUTICAMENTE ACEPTABLE Y COMPOSICIoN FARMACÉUTICA QUE LA CONTIENE. AR014167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides

Publications (1)

Publication Number Publication Date
AR014167A1 true AR014167A1 (es) 2001-02-07

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980106652A AR014167A1 (es) 1997-12-23 1998-12-23 UNA AMIDA PEPTíDICA OPIOIDE SINTÉTICA O UNA SAL FARMACÉUTICAMENTE ACEPTABLE Y COMPOSICIoN FARMACÉUTICA QUE LA CONTIENE.

Country Status (33)

Country Link
US (1) US5965701A (es)
EP (1) EP1042359B1 (es)
JP (1) JP4275852B2 (es)
KR (1) KR100629548B1 (es)
CN (1) CN1154655C (es)
AR (1) AR014167A1 (es)
AT (1) ATE301670T1 (es)
AU (1) AU747806B2 (es)
BR (2) BR9814499B1 (es)
CA (1) CA2315878C (es)
CR (1) CR5936A (es)
CZ (1) CZ297281B6 (es)
DE (1) DE69831176T2 (es)
DK (1) DK1042359T3 (es)
EE (1) EE04440B1 (es)
ES (1) ES2247735T3 (es)
HK (1) HK1029349A1 (es)
HR (1) HRP20000415B1 (es)
HU (1) HU227640B1 (es)
IL (3) IL136742A0 (es)
MY (1) MY117542A (es)
NO (1) NO327080B1 (es)
NZ (1) NZ505183A (es)
PL (1) PL195842B1 (es)
PT (1) PT1042359E (es)
RU (1) RU2217437C2 (es)
SK (1) SK286135B6 (es)
TR (1) TR200001985T2 (es)
TW (1) TW580502B (es)
UA (1) UA68366C2 (es)
UY (1) UY25327A1 (es)
WO (1) WO1999032510A1 (es)
ZA (1) ZA9811801B (es)

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WO2001036006A1 (en) * 1999-11-19 2001-05-25 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CN1283317C (zh) * 2001-05-08 2006-11-08 东丽株式会社 类鸦片κ受体激动性化合物在制备治疗败血症的药物中的应用
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US7709639B2 (en) 2004-08-20 2010-05-04 Mannkind Corporation Catalysis of diketopiperazine synthesis
PL2314298T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Mikrocząstki zawierające sole diketopiperazyny do dostarczania leków
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
EP2029617A2 (en) * 2006-05-26 2009-03-04 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
CN101454017A (zh) * 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 提升哺乳动物催乳素的方法
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
JP5244810B2 (ja) 2006-11-10 2013-07-24 カラ セラピューティクス インコーポレイテッド 合成ペプチドアミド
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
CN106039494B (zh) 2008-06-13 2019-12-24 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2300083T3 (da) 2008-06-20 2013-07-22 Mannkind Corp Interaktivt apparat og fremgangsmåde til realtids-profilering af inhalationsforsøg
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
BR122020008875B8 (pt) 2011-04-01 2022-12-06 Mannkind Corp Embalagem de bolha e método de fabricação de uma embalagem de bolhas
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) * 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
CN105451716A (zh) 2013-07-18 2016-03-30 曼金德公司 热稳定性干粉药物组合物和方法
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
RU2664545C2 (ru) * 2014-06-26 2018-08-20 Маруиси Фармасьютикал Ко., Лтд. Способ получения синтетического пентапептида
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016181408A2 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
US11084847B2 (en) 2016-09-27 2021-08-10 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Polyamide compound and use thereof
BR112020001157A2 (pt) * 2017-07-21 2020-07-21 Sichuan Haisco Pharmaceutical Co., Ltd. compostos de peptídeo amida, método de preparação dos mesmos e uso em medicina
CN111065631B (zh) 2017-12-06 2021-10-08 江苏恒瑞医药股份有限公司 一种苯基丙酰胺类衍生物的盐及其制备方法
UA126835C2 (uk) 2018-05-16 2023-02-08 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція агоніста рецептора kor
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
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Also Published As

Publication number Publication date
CR5936A (es) 2006-08-18
ATE301670T1 (de) 2005-08-15
EE04440B1 (et) 2005-02-15
CA2315878C (en) 2010-11-16
UY25327A1 (es) 2000-12-29
MY117542A (en) 2004-07-31
BR9814499A (pt) 2000-10-10
BRPI9814499B8 (pt) 2021-11-09
NZ505183A (en) 2001-09-28
UA68366C2 (en) 2004-08-16
TW580502B (en) 2004-03-21
DE69831176D1 (de) 2005-09-15
HRP20000415B1 (en) 2004-06-30
ES2247735T3 (es) 2006-03-01
EP1042359B1 (en) 2005-08-10
CN1283201A (zh) 2001-02-07
BRPI9814499B1 (pt) 2014-10-21
HU227640B1 (en) 2011-10-28
PT1042359E (pt) 2005-11-30
ZA9811801B (en) 1999-06-22
CZ20002382A3 (cs) 2000-12-13
US5965701A (en) 1999-10-12
WO1999032510A1 (en) 1999-07-01
HUP0100626A3 (en) 2001-12-28
NO20003245L (no) 2000-08-23
WO1999032510A9 (en) 1999-09-23
JP4275852B2 (ja) 2009-06-10
BR9814499B1 (pt) 2014-10-21
CA2315878A1 (en) 1999-07-01
AU1940299A (en) 1999-07-12
CN1154655C (zh) 2004-06-23
NO327080B1 (no) 2009-04-20
IL136742A (en) 2006-12-31
IL136742A0 (en) 2001-06-14
HRP20000415A2 (en) 2000-12-31
JP2001526295A (ja) 2001-12-18
SK286135B6 (sk) 2008-04-07
EE200000370A (et) 2001-10-15
KR100629548B1 (ko) 2006-09-27
IL178471A0 (en) 2007-02-11
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
PL195842B1 (pl) 2007-10-31
AU747806B2 (en) 2002-05-23
HK1029349A1 (en) 2001-03-30
TR200001985T2 (tr) 2000-11-21
DE69831176T2 (de) 2006-04-20
NO20003245D0 (no) 2000-06-21
RU2217437C2 (ru) 2003-11-27
KR20010033450A (ko) 2001-04-25
SK9602000A3 (en) 2001-01-18
BRPI9814499A (pt) 2000-10-10
DK1042359T3 (da) 2005-11-28
PL341308A1 (en) 2001-04-09
EP1042359A1 (en) 2000-10-11

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