PT1042359E - Peptidos optioides para o receptor kapa - Google Patents

Peptidos optioides para o receptor kapa

Info

Publication number
PT1042359E
PT1042359E PT98964224T PT98964224T PT1042359E PT 1042359 E PT1042359 E PT 1042359E PT 98964224 T PT98964224 T PT 98964224T PT 98964224 T PT98964224 T PT 98964224T PT 1042359 E PT1042359 E PT 1042359E
Authority
PT
Portugal
Prior art keywords
kapa
receptor
peptides
optional
optional peptides
Prior art date
Application number
PT98964224T
Other languages
English (en)
Inventor
Junien Jean Louis
Pierre J M Riviere
Claudio D Schteingart
Diaz Javier Sueiras
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Cara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc filed Critical Cara Therapeutics Inc
Publication of PT1042359E publication Critical patent/PT1042359E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT98964224T 1997-12-23 1998-12-22 Peptidos optioides para o receptor kapa PT1042359E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides

Publications (1)

Publication Number Publication Date
PT1042359E true PT1042359E (pt) 2005-11-30

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98964224T PT1042359E (pt) 1997-12-23 1998-12-22 Peptidos optioides para o receptor kapa

Country Status (33)

Country Link
US (1) US5965701A (pt)
EP (1) EP1042359B1 (pt)
JP (1) JP4275852B2 (pt)
KR (1) KR100629548B1 (pt)
CN (1) CN1154655C (pt)
AR (1) AR014167A1 (pt)
AT (1) ATE301670T1 (pt)
AU (1) AU747806B2 (pt)
BR (2) BRPI9814499B8 (pt)
CA (1) CA2315878C (pt)
CR (1) CR5936A (pt)
CZ (1) CZ297281B6 (pt)
DE (1) DE69831176T2 (pt)
DK (1) DK1042359T3 (pt)
EE (1) EE04440B1 (pt)
ES (1) ES2247735T3 (pt)
HK (1) HK1029349A1 (pt)
HR (1) HRP20000415B1 (pt)
HU (1) HU227640B1 (pt)
IL (3) IL136742A0 (pt)
MY (1) MY117542A (pt)
NO (1) NO327080B1 (pt)
NZ (1) NZ505183A (pt)
PL (1) PL195842B1 (pt)
PT (1) PT1042359E (pt)
RU (1) RU2217437C2 (pt)
SK (1) SK286135B6 (pt)
TR (1) TR200001985T2 (pt)
TW (1) TW580502B (pt)
UA (1) UA68366C2 (pt)
UY (1) UY25327A1 (pt)
WO (1) WO1999032510A1 (pt)
ZA (1) ZA9811801B (pt)

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DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
EP1402899A4 (en) * 2001-05-08 2009-03-11 Toray Industries MEANS FOR THE TREATMENT OF SEPSIS
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007139921A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
WO2007139826A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
AU2007317817B2 (en) * 2006-11-10 2012-09-20 Cara Therapeutics, Inc. Synthetic peptide amides
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AR072114A1 (es) 2008-06-13 2010-08-04 Mannkind Corp Un inhalador de polvo seco y sistema para suministro de farmacos
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
AU2014290438B2 (en) 2013-07-18 2019-11-07 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
MX2016016479A (es) * 2014-06-26 2017-04-10 Maruishi Pharma Metodo para producir un pentapeptido sintetico.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10550150B2 (en) * 2015-05-11 2020-02-04 Cadila Healthcare Limited Short-chain peptides as Kappa (κ) opioid receptors (KOR) agonist
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
CN109563133B (zh) * 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
CN110637025B (zh) * 2017-07-21 2023-07-18 四川海思科制药有限公司 肽酰胺类化合物及其制备方法和在医药上的用途
MX2020005932A (es) 2017-12-06 2020-08-24 Jiangsu Hengrui Medicine Co Sal de derivado de fenilpropionamida y su metodo de preparacion.
TW202015716A (zh) 2018-05-16 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種ｋｏｒ受體激動劑醫藥組成物
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
CN114127085A (zh) * 2019-07-25 2022-03-01 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
US20210040150A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
CN115884963A (zh) 2020-06-25 2023-03-31 人福医药美国公司 用于治疗医学病症的肽
WO2023278843A2 (en) 2021-07-02 2023-01-05 Acer Therapeutics, Inc. Solid forms of osanetant

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US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
IL136742A (en) 2006-12-31
HRP20000415A2 (en) 2000-12-31
HUP0100626A3 (en) 2001-12-28
BR9814499B1 (pt) 2014-10-21
CA2315878A1 (en) 1999-07-01
CN1283201A (zh) 2001-02-07
NO20003245D0 (no) 2000-06-21
NO327080B1 (no) 2009-04-20
DK1042359T3 (da) 2005-11-28
ATE301670T1 (de) 2005-08-15
IL178471A0 (en) 2007-02-11
PL195842B1 (pl) 2007-10-31
PL341308A1 (en) 2001-04-09
CR5936A (es) 2006-08-18
TR200001985T2 (tr) 2000-11-21
SK286135B6 (sk) 2008-04-07
UA68366C2 (en) 2004-08-16
KR100629548B1 (ko) 2006-09-27
UY25327A1 (es) 2000-12-29
MY117542A (en) 2004-07-31
WO1999032510A9 (en) 1999-09-23
ES2247735T3 (es) 2006-03-01
HU227640B1 (en) 2011-10-28
CA2315878C (en) 2010-11-16
SK9602000A3 (en) 2001-01-18
BRPI9814499B8 (pt) 2021-11-09
BR9814499A (pt) 2000-10-10
BRPI9814499B1 (pt) 2014-10-21
HRP20000415B1 (en) 2004-06-30
CZ20002382A3 (cs) 2000-12-13
RU2217437C2 (ru) 2003-11-27
JP4275852B2 (ja) 2009-06-10
US5965701A (en) 1999-10-12
JP2001526295A (ja) 2001-12-18
ZA9811801B (en) 1999-06-22
TW580502B (en) 2004-03-21
EP1042359B1 (en) 2005-08-10
KR20010033450A (ko) 2001-04-25
AR014167A1 (es) 2001-02-07
DE69831176T2 (de) 2006-04-20
BRPI9814499A (pt) 2000-10-10
DE69831176D1 (de) 2005-09-15
EP1042359A1 (en) 2000-10-11
EE200000370A (et) 2001-10-15
AU747806B2 (en) 2002-05-23
WO1999032510A1 (en) 1999-07-01
IL136742A0 (en) 2001-06-14
CN1154655C (zh) 2004-06-23
NO20003245L (no) 2000-08-23
AU1940299A (en) 1999-07-12
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
HK1029349A1 (en) 2001-03-30
NZ505183A (en) 2001-09-28
EE04440B1 (et) 2005-02-15

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