EE04440B1 - Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon - Google Patents

Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon

Info

Publication number
EE04440B1
EE04440B1 EEP200000370A EEP200000370A EE04440B1 EE 04440 B1 EE04440 B1 EE 04440B1 EE P200000370 A EEP200000370 A EE P200000370A EE P200000370 A EEP200000370 A EE P200000370A EE 04440 B1 EE04440 B1 EE 04440B1
Authority
EE
Estonia
Prior art keywords
capareceptor
pharmaceutical composition
opioid peptides
opioid
peptides
Prior art date
Application number
EEP200000370A
Other languages
English (en)
Inventor
Louis Junien Jean
J. M. Riviere Pierre
D. Schteingart Claudio
Sueiras Diaz Javier
A. Trojnar Jerzy
W. Vanderah Todd
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of EE200000370A publication Critical patent/EE200000370A/et
Publication of EE04440B1 publication Critical patent/EE04440B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200000370A 1997-12-23 1998-12-22 Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon EE04440B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
EE200000370A EE200000370A (et) 2001-10-15
EE04440B1 true EE04440B1 (et) 2005-02-15

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000370A EE04440B1 (et) 1997-12-23 1998-12-22 Kaparetseptori opioidpeptiidid ja farmatseutilinekompositsioon

Country Status (32)

Country Link
US (1) US5965701A (et)
EP (1) EP1042359B1 (et)
JP (1) JP4275852B2 (et)
KR (1) KR100629548B1 (et)
CN (1) CN1154655C (et)
AR (1) AR014167A1 (et)
AT (1) ATE301670T1 (et)
AU (1) AU747806B2 (et)
BR (2) BR9814499B1 (et)
CA (1) CA2315878C (et)
CR (1) CR5936A (et)
CZ (1) CZ297281B6 (et)
DE (1) DE69831176T2 (et)
DK (1) DK1042359T3 (et)
EE (1) EE04440B1 (et)
ES (1) ES2247735T3 (et)
HR (1) HRP20000415B1 (et)
HU (1) HU227640B1 (et)
IL (3) IL136742A0 (et)
MY (1) MY117542A (et)
NO (1) NO327080B1 (et)
NZ (1) NZ505183A (et)
PL (1) PL195842B1 (et)
PT (1) PT1042359E (et)
RU (1) RU2217437C2 (et)
SK (1) SK286135B6 (et)
TR (1) TR200001985T2 (et)
TW (1) TW580502B (et)
UA (1) UA68366C2 (et)
UY (1) UY25327A1 (et)
WO (1) WO1999032510A1 (et)
ZA (1) ZA9811801B (et)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2451133C (en) * 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
EP1894591B1 (en) 2002-03-20 2013-06-26 MannKind Corporation Cartridge for an inhalation apparatus
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
DK2314298T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Microparticles comprising diketopiperazinsalte for drug delivery
BRPI0616071B8 (pt) 2005-09-14 2021-05-25 Mannkind Corp métodos de revestir uma micropartícula cristalina pré-formada em suspensão com um agente ativo
IN2015DN00888A (et) 2006-02-22 2015-07-10 Mannkind Corp
EP2029617A2 (en) * 2006-05-26 2009-03-04 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
WO2007139826A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
CA2667155C (en) 2006-11-10 2016-05-10 Cara Therapeutics, Inc. Synthetic peptide amides
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
TWI592178B (zh) 2008-06-13 2017-07-21 曼凱公司 用於藥物傳輸之乾粉吸入器及系統
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
TWI547487B (zh) 2009-06-12 2016-09-01 曼凱公司 具限定比表面積之二酮基哌微粒子
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
US8925726B2 (en) 2011-04-01 2015-01-06 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP6018640B2 (ja) * 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
ES2624294T3 (es) 2012-07-12 2017-07-13 Mannkind Corporation Sistemas de suministro de fármacos en polvo seco
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
KR102246914B1 (ko) 2013-03-15 2021-04-30 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
TR201902611T4 (tr) * 2014-06-26 2019-03-21 Maruishi Pharma Sentetik pentapeptit üretme metodu.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6651546B2 (ja) * 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド カッパ（κ）オピオイド受容体（ＫＯＲ）アゴニストとしての新規の短鎖ペプチド
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
JP6794602B2 (ja) * 2016-09-27 2020-12-02 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ポリアミド化合物及びその使用
TWI712615B (zh) * 2017-07-21 2020-12-11 大陸商四川海思科製藥有限公司 肽醯胺類化合物、其製備方法及醫藥用途
US11180530B2 (en) 2017-12-06 2021-11-23 Jiangsu Hengrui Medicine Co., Ltd. Salt of phenylpropionamide derivative and preparation method therefor
US20210205404A1 (en) 2018-05-16 2021-07-08 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition of kor receptor agonist
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
US12215173B2 (en) 2019-08-07 2025-02-04 HUMANWELL PHARMACEUTICAL US, Inc. Kappa opioid receptor peptide amide ligands
WO2021262173A1 (en) 2020-06-25 2021-12-30 Humanwell Pharmaceutical US Peptides for treatment of medical disorders
WO2023278843A2 (en) 2021-07-02 2023-01-05 Acer Therapeutics, Inc. Solid forms of osanetant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2013689B (en) * 1977-12-15 1982-03-24 Reckitt & Colmann Prod Ltd Compounds
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
RU2067000C1 (ru) * 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
SK286135B6 (sk) 2008-04-07
WO1999032510A9 (en) 1999-09-23
HRP20000415A2 (en) 2000-12-31
PL341308A1 (en) 2001-04-09
DE69831176T2 (de) 2006-04-20
HRP20000415B1 (en) 2004-06-30
IL178471A0 (en) 2007-02-11
JP2001526295A (ja) 2001-12-18
CA2315878A1 (en) 1999-07-01
US5965701A (en) 1999-10-12
IL136742A (en) 2006-12-31
HUP0100626A3 (en) 2001-12-28
UY25327A1 (es) 2000-12-29
EP1042359A1 (en) 2000-10-11
ZA9811801B (en) 1999-06-22
CR5936A (es) 2006-08-18
AR014167A1 (es) 2001-02-07
DE69831176D1 (de) 2005-09-15
RU2217437C2 (ru) 2003-11-27
KR20010033450A (ko) 2001-04-25
SK9602000A3 (en) 2001-01-18
TR200001985T2 (tr) 2000-11-21
DK1042359T3 (da) 2005-11-28
HU227640B1 (en) 2011-10-28
UA68366C2 (en) 2004-08-16
WO1999032510A1 (en) 1999-07-01
BRPI9814499B8 (pt) 2021-11-09
AU747806B2 (en) 2002-05-23
NO20003245L (no) 2000-08-23
BRPI9814499A (pt) 2000-10-10
NO327080B1 (no) 2009-04-20
EP1042359B1 (en) 2005-08-10
TW580502B (en) 2004-03-21
CN1283201A (zh) 2001-02-07
BR9814499A (pt) 2000-10-10
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
KR100629548B1 (ko) 2006-09-27
AU1940299A (en) 1999-07-12
CA2315878C (en) 2010-11-16
ES2247735T3 (es) 2006-03-01
HK1029349A1 (en) 2001-03-30
MY117542A (en) 2004-07-31
PT1042359E (pt) 2005-11-30
PL195842B1 (pl) 2007-10-31
NZ505183A (en) 2001-09-28
EE200000370A (et) 2001-10-15
CZ20002382A3 (cs) 2000-12-13
CN1154655C (zh) 2004-06-23
BR9814499B1 (pt) 2014-10-21
BRPI9814499B1 (pt) 2014-10-21
ATE301670T1 (de) 2005-08-15
JP4275852B2 (ja) 2009-06-10
IL136742A0 (en) 2001-06-14
NO20003245D0 (no) 2000-06-21

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20051231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20121222