BR9814499A - Peptìdeo amida opióide sintético ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, processo para tratamento compreendendo a administração de uma quantidade da mesma - Google Patents
Peptìdeo amida opióide sintético ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, processo para tratamento compreendendo a administração de uma quantidade da mesmaInfo
- Publication number
- BR9814499A BR9814499A BR9814499-5A BR9814499A BR9814499A BR 9814499 A BR9814499 A BR 9814499A BR 9814499 A BR9814499 A BR 9814499A BR 9814499 A BR9814499 A BR 9814499A
- Authority
- BR
- Brazil
- Prior art keywords
- phe
- nle
- arg
- morpholinyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PEPTìDEO AMIDA OPIóIDE SINTéTICO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA TRATAMENTO COMPREENDENDO A ADMINISTRAçãO DE UMA QUANTIDADE DA MESMA". Peptídeos que demonstram alta seletividade para o receptor opióide kappa (KOR) e longa duração de ação periférica sem entrada significante no cerébro são criados que são seq³ências de quatro resíduos de aminoácidos D-isómero tendo um C-término que é uma amida mono- ou disubstituída. Os compostos representativos, que tem uma afinidade para o KOR de pelo menos 1000 vezes sua afinidade para o receptor opióide mu e um ED~ 50~ não maior que cerca de 0,5 mg/kg, incluem H-D-Phe-D-Phe-D-Nle-D-Arg-NHEt, H-D-Phe-D-Phe-D-Nle-D-Arg-morfolinila, H-D-Phe-D-Phe-D-Nle-D-Arg-Nh-4-picolila, H-D-Phe-D-Phe-D-Nle-D-Arg-NHPr,H-D-Phe-D-Phe-D-Nle-D-Arg-tio morfolinila, H-D-Phe-D-Phe-D-Nle-D-Arg-Net~ 2~, H-D-Phe-D-Phe-D-Nle-D-Arg-NHMe, H-D-Phe-D-Phe-D-Nle-D-Orn-morfolinila, H-D-4Fpa-D-Phe-D-Nle-D-Arg-NH-4-picolila, H-D-Phe-D-Phe-D-Nle-D-Arg-NH-ciclopropila, H-D-Ala(2Thi)D-3,4-Cpa-D-Leu-D-Arg-morfolinila, H-D-Phe-D-Phe-D-Nle-D-Gmf-morfolinila, H-D-Phe-D-Phe-D-Leu-D-Orn-NH (Aeb), H-D-Phe-D-Phe-D-Leu-D-Lys-morfolinila, H-D-Phe-D-Phe-D-Nle-D-Arg-piperazinila, e H-D-Phe-D-Phe-D-Nle-D-Arg-NH(Hoh).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/997208 | 1997-12-23 | ||
| US08/997,208 US5965701A (en) | 1997-12-23 | 1997-12-23 | Kappa receptor opioid peptides |
| PCT/US1998/027282 WO1999032510A1 (en) | 1997-12-23 | 1998-12-22 | Kappa receptor opioid peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9814499A true BR9814499A (pt) | 2000-10-10 |
| BR9814499B1 BR9814499B1 (pt) | 2014-10-21 |
Family
ID=25543752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9814499A BRPI9814499B8 (pt) | 1997-12-23 | 1998-12-22 | Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica |
| BRPI9814499-5A BR9814499B1 (pt) | 1997-12-23 | 1998-12-22 | Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9814499A BRPI9814499B8 (pt) | 1997-12-23 | 1998-12-22 | Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5965701A (pt) |
| EP (1) | EP1042359B1 (pt) |
| JP (1) | JP4275852B2 (pt) |
| KR (1) | KR100629548B1 (pt) |
| CN (1) | CN1154655C (pt) |
| AR (1) | AR014167A1 (pt) |
| AT (1) | ATE301670T1 (pt) |
| AU (1) | AU747806B2 (pt) |
| BR (2) | BRPI9814499B8 (pt) |
| CA (1) | CA2315878C (pt) |
| CR (1) | CR5936A (pt) |
| CZ (1) | CZ297281B6 (pt) |
| DE (1) | DE69831176T2 (pt) |
| DK (1) | DK1042359T3 (pt) |
| EE (1) | EE04440B1 (pt) |
| ES (1) | ES2247735T3 (pt) |
| HK (1) | HK1029349A1 (pt) |
| HR (1) | HRP20000415B1 (pt) |
| HU (1) | HU227640B1 (pt) |
| IL (3) | IL136742A0 (pt) |
| MY (1) | MY117542A (pt) |
| NO (1) | NO327080B1 (pt) |
| NZ (1) | NZ505183A (pt) |
| PL (1) | PL195842B1 (pt) |
| PT (1) | PT1042359E (pt) |
| RU (1) | RU2217437C2 (pt) |
| SK (1) | SK286135B6 (pt) |
| TR (1) | TR200001985T2 (pt) |
| TW (1) | TW580502B (pt) |
| UA (1) | UA68366C2 (pt) |
| UY (1) | UY25327A1 (pt) |
| WO (1) | WO1999032510A1 (pt) |
| ZA (1) | ZA9811801B (pt) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| AU1623801A (en) * | 1999-11-19 | 2001-05-30 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
| DE10116978A1 (de) * | 2001-04-05 | 2002-10-10 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase |
| EP1402899A4 (en) * | 2001-05-08 | 2009-03-11 | Toray Industries | MEANS FOR THE TREATMENT OF SEPSIS |
| ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
| CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| HUE028691T2 (en) | 2005-09-14 | 2016-12-28 | Mannkind Corp | A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| WO2007139921A2 (en) * | 2006-05-26 | 2007-12-06 | Cara Therapeutics, Inc. | N-oxides of kappa opioid receptor peptides |
| WO2007139826A2 (en) * | 2006-05-26 | 2007-12-06 | Cara Therapeutics, Inc. | Method for elevating prolactin in mammals |
| US7842662B2 (en) * | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| AU2007317817B2 (en) * | 2006-11-10 | 2012-09-20 | Cara Therapeutics, Inc. | Synthetic peptide amides |
| US8236766B2 (en) * | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| US7713937B2 (en) * | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| US8906859B2 (en) * | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| WO2008077194A1 (en) * | 2006-12-22 | 2008-07-03 | Xenome Ltd | Receptor agonists |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| AR072114A1 (es) | 2008-06-13 | 2010-08-04 | Mannkind Corp | Un inhalador de polvo seco y sistema para suministro de farmacos |
| BRPI0914308B8 (pt) | 2008-06-20 | 2021-06-22 | Mannkind Corp | sistema de inalação |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
| RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
| SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| MX2016016479A (es) * | 2014-06-26 | 2017-04-10 | Maruishi Pharma | Metodo para producir un pentapeptido sintetico. |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| US10550150B2 (en) * | 2015-05-11 | 2020-02-04 | Cadila Healthcare Limited | Short-chain peptides as Kappa (κ) opioid receptors (KOR) agonist |
| CN107098876B (zh) * | 2016-02-23 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用 |
| CN109563133B (zh) * | 2016-09-27 | 2020-09-11 | 四川科伦博泰生物医药股份有限公司 | 多酰胺化合物及其用途 |
| CN110637025B (zh) * | 2017-07-21 | 2023-07-18 | 四川海思科制药有限公司 | 肽酰胺类化合物及其制备方法和在医药上的用途 |
| MX2020005932A (es) | 2017-12-06 | 2020-08-24 | Jiangsu Hengrui Medicine Co | Sal de derivado de fenilpropionamida y su metodo de preparacion. |
| TW202015716A (zh) | 2018-05-16 | 2020-05-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種ｋｏｒ受體激動劑醫藥組成物 |
| CN114127086B (zh) * | 2019-07-25 | 2023-10-20 | 四川海思科制药有限公司 | 氘代肽酰胺类化合物及其制备方法和在医药上的用途 |
| CN114127085A (zh) * | 2019-07-25 | 2022-03-01 | 四川海思科制药有限公司 | 一种肽酰胺盐及其制备方法和在医药上的用途 |
| US20210040150A1 (en) * | 2019-08-07 | 2021-02-11 | Humanwell Pharmaceutical US | Kappa opioid receptor peptide amide agonists |
| CN115884963A (zh) | 2020-06-25 | 2023-03-31 | 人福医药美国公司 | 用于治疗医学病症的肽 |
| WO2023278843A2 (en) | 2021-07-02 | 2023-01-05 | Acer Therapeutics, Inc. | Solid forms of osanetant |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2013689B (en) * | 1977-12-15 | 1982-03-24 | Reckitt & Colmann Prod Ltd | Compounds |
| GB8801304D0 (en) * | 1988-01-21 | 1988-02-17 | Ici Plc | Diamine compounds |
| US5367053A (en) * | 1993-05-19 | 1994-11-22 | Houghten Pharmaceuticals, Inc. | Opioid peptide inhibitors |
| US5610271A (en) * | 1995-06-07 | 1997-03-11 | Torrey Pines Institute For Molecular Studies | Kappa receptor selective opioid peptides |
-
1997
- 1997-12-23 US US08/997,208 patent/US5965701A/en not_active Expired - Lifetime
-
1998
- 1998-12-22 DE DE69831176T patent/DE69831176T2/de not_active Expired - Lifetime
- 1998-12-22 UA UA2000063810A patent/UA68366C2/uk unknown
- 1998-12-22 TR TR2000/01985T patent/TR200001985T2/xx unknown
- 1998-12-22 DK DK98964224T patent/DK1042359T3/da active
- 1998-12-22 AT AT98964224T patent/ATE301670T1/de active
- 1998-12-22 ES ES98964224T patent/ES2247735T3/es not_active Expired - Lifetime
- 1998-12-22 RU RU2000119773/04A patent/RU2217437C2/ru active
- 1998-12-22 HU HU0100626A patent/HU227640B1/hu not_active IP Right Cessation
- 1998-12-22 CR CR5936A patent/CR5936A/es unknown
- 1998-12-22 CN CNB98812582XA patent/CN1154655C/zh not_active Expired - Lifetime
- 1998-12-22 IL IL13674298A patent/IL136742A0/xx active IP Right Grant
- 1998-12-22 ZA ZA9811801A patent/ZA9811801B/xx unknown
- 1998-12-22 WO PCT/US1998/027282 patent/WO1999032510A1/en active IP Right Grant
- 1998-12-22 AU AU19402/99A patent/AU747806B2/en not_active Ceased
- 1998-12-22 KR KR1020007006936A patent/KR100629548B1/ko not_active IP Right Cessation
- 1998-12-22 SK SK960-2000A patent/SK286135B6/sk not_active IP Right Cessation
- 1998-12-22 EP EP98964224A patent/EP1042359B1/en not_active Expired - Lifetime
- 1998-12-22 EE EEP200000370A patent/EE04440B1/xx not_active IP Right Cessation
- 1998-12-22 JP JP2000525447A patent/JP4275852B2/ja not_active Expired - Lifetime
- 1998-12-22 CZ CZ20002382A patent/CZ297281B6/cs not_active IP Right Cessation
- 1998-12-22 PL PL98341308A patent/PL195842B1/pl not_active IP Right Cessation
- 1998-12-22 CA CA2315878A patent/CA2315878C/en not_active Expired - Lifetime
- 1998-12-22 NZ NZ505183A patent/NZ505183A/en not_active IP Right Cessation
- 1998-12-22 MY MYPI98005818A patent/MY117542A/en unknown
- 1998-12-22 PT PT98964224T patent/PT1042359E/pt unknown
- 1998-12-22 BR BRPI9814499A patent/BRPI9814499B8/pt unknown
- 1998-12-22 BR BRPI9814499-5A patent/BR9814499B1/pt not_active IP Right Cessation
- 1998-12-23 UY UY25327A patent/UY25327A1/es unknown
- 1998-12-23 AR ARP980106652A patent/AR014167A1/es active IP Right Grant
-
1999
- 1999-02-10 TW TW087121390A patent/TW580502B/zh not_active IP Right Cessation
-
2000
- 2000-06-12 IL IL136742A patent/IL136742A/en not_active IP Right Cessation
- 2000-06-20 HR HR20000415A patent/HRP20000415B1/xx not_active IP Right Cessation
- 2000-06-21 NO NO20003245A patent/NO327080B1/no not_active IP Right Cessation
- 2000-11-28 HK HK00107625A patent/HK1029349A1/xx not_active IP Right Cessation
-
2006
- 2006-10-05 IL IL178471A patent/IL178471A0/en unknown
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