HK1029349A1 - Kappa receptor opioid peptides - Google Patents

Kappa receptor opioid peptides

Info

Publication number
HK1029349A1
HK1029349A1 HK00107625A HK00107625A HK1029349A1 HK 1029349 A1 HK1029349 A1 HK 1029349A1 HK 00107625 A HK00107625 A HK 00107625A HK 00107625 A HK00107625 A HK 00107625A HK 1029349 A1 HK1029349 A1 HK 1029349A1
Authority
HK
Hong Kong
Prior art keywords
opioid peptides
kappa receptor
receptor opioid
kappa
peptides
Prior art date
Application number
HK00107625A
Other languages
English (en)
Inventor
Jean Louis Junien
Pierre J M Riviere
Claudio D Schteingart
Javier Sueiras Diaz
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Cara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc filed Critical Cara Therapeutics Inc
Publication of HK1029349A1 publication Critical patent/HK1029349A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK00107625A 1997-12-23 2000-11-28 Kappa receptor opioid peptides HK1029349A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (1)

Publication Number Publication Date
HK1029349A1 true HK1029349A1 (en) 2001-03-30

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00107625A HK1029349A1 (en) 1997-12-23 2000-11-28 Kappa receptor opioid peptides

Country Status (33)

Country Link
US (1) US5965701A (xx)
EP (1) EP1042359B1 (xx)
JP (1) JP4275852B2 (xx)
KR (1) KR100629548B1 (xx)
CN (1) CN1154655C (xx)
AR (1) AR014167A1 (xx)
AT (1) ATE301670T1 (xx)
AU (1) AU747806B2 (xx)
BR (2) BR9814499B1 (xx)
CA (1) CA2315878C (xx)
CR (1) CR5936A (xx)
CZ (1) CZ297281B6 (xx)
DE (1) DE69831176T2 (xx)
DK (1) DK1042359T3 (xx)
EE (1) EE04440B1 (xx)
ES (1) ES2247735T3 (xx)
HK (1) HK1029349A1 (xx)
HR (1) HRP20000415B1 (xx)
HU (1) HU227640B1 (xx)
IL (3) IL136742A0 (xx)
MY (1) MY117542A (xx)
NO (1) NO327080B1 (xx)
NZ (1) NZ505183A (xx)
PL (1) PL195842B1 (xx)
PT (1) PT1042359E (xx)
RU (1) RU2217437C2 (xx)
SK (1) SK286135B6 (xx)
TR (1) TR200001985T2 (xx)
TW (1) TW580502B (xx)
UA (1) UA68366C2 (xx)
UY (1) UY25327A1 (xx)
WO (1) WO1999032510A1 (xx)
ZA (1) ZA9811801B (xx)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
WO2001036006A1 (en) * 1999-11-19 2001-05-25 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
WO2002089845A1 (en) * 2001-05-08 2002-11-14 Toray Industries, Inc. Remedies for sepsis
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
WO2006023849A2 (en) 2004-08-20 2006-03-02 Mannkind Corporation Catalysis of diketopiperazine synthesis
DK2314298T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Microparticles comprising diketopiperazinsalte for drug delivery
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
EP2040733A2 (en) * 2006-05-26 2009-04-01 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
WO2007139921A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
DK2064228T3 (da) * 2006-11-10 2012-12-10 Cara Therapeutics Inc Syntetiske peptidamider
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) * 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2014012069A2 (en) 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
KR102246914B1 (ko) 2013-03-15 2021-04-30 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2015198505A1 (ja) * 2014-06-26 2015-12-30 積水メディカル株式会社 合成ペンタペプチドの製造法
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10550150B2 (en) * 2015-05-11 2020-02-04 Cadila Healthcare Limited Short-chain peptides as Kappa (κ) opioid receptors (KOR) agonist
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
WO2018059331A1 (zh) * 2016-09-27 2018-04-05 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
ES2905164T3 (es) 2017-07-21 2022-04-07 Sichuan Haisco Pharmaceutical Co Ltd Compuesto de amida peptídico y método de preparación y uso médico del mismo
BR112020011191A2 (pt) 2017-12-06 2020-11-17 Jiangsu Hengrui Medicine Co., Ltd. sal de derivado de fenilpropionamida, métodos para preparar o mesmo, bem como sua composição farmacêutica e uso dos mesmos
CN111148526B (zh) 2018-05-16 2023-03-10 江苏恒瑞医药股份有限公司 一种kor受体激动剂药物组合物
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
WO2021013086A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
CA3180729A1 (en) 2020-06-25 2021-12-30 Subo Liao Peptides for treatment of medical disorders
US20240336565A1 (en) 2021-07-02 2024-10-10 Acer Therapeutics, Inc. Solid forms of osanetant

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GB2013689B (en) * 1977-12-15 1982-03-24 Reckitt & Colmann Prod Ltd Compounds
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
US5965701A (en) 1999-10-12
CZ20002382A3 (cs) 2000-12-13
EP1042359A1 (en) 2000-10-11
ZA9811801B (en) 1999-06-22
KR100629548B1 (ko) 2006-09-27
AU1940299A (en) 1999-07-12
JP2001526295A (ja) 2001-12-18
EP1042359B1 (en) 2005-08-10
CA2315878A1 (en) 1999-07-01
PT1042359E (pt) 2005-11-30
MY117542A (en) 2004-07-31
EE200000370A (et) 2001-10-15
CN1154655C (zh) 2004-06-23
BR9814499A (pt) 2000-10-10
AR014167A1 (es) 2001-02-07
AU747806B2 (en) 2002-05-23
DK1042359T3 (da) 2005-11-28
RU2217437C2 (ru) 2003-11-27
IL178471A0 (en) 2007-02-11
NZ505183A (en) 2001-09-28
BRPI9814499B1 (pt) 2014-10-21
HRP20000415B1 (en) 2004-06-30
JP4275852B2 (ja) 2009-06-10
BRPI9814499A (pt) 2000-10-10
NO20003245D0 (no) 2000-06-21
NO327080B1 (no) 2009-04-20
HRP20000415A2 (en) 2000-12-31
PL341308A1 (en) 2001-04-09
CN1283201A (zh) 2001-02-07
CZ297281B6 (cs) 2006-10-11
SK286135B6 (sk) 2008-04-07
HUP0100626A3 (en) 2001-12-28
ES2247735T3 (es) 2006-03-01
TW580502B (en) 2004-03-21
ATE301670T1 (de) 2005-08-15
BRPI9814499B8 (pt) 2021-11-09
TR200001985T2 (tr) 2000-11-21
CA2315878C (en) 2010-11-16
DE69831176D1 (de) 2005-09-15
WO1999032510A9 (en) 1999-09-23
HUP0100626A2 (hu) 2001-08-28
SK9602000A3 (en) 2001-01-18
DE69831176T2 (de) 2006-04-20
BR9814499B1 (pt) 2014-10-21
IL136742A (en) 2006-12-31
UY25327A1 (es) 2000-12-29
NO20003245L (no) 2000-08-23
PL195842B1 (pl) 2007-10-31
IL136742A0 (en) 2001-06-14
WO1999032510A1 (en) 1999-07-01
KR20010033450A (ko) 2001-04-25
HU227640B1 (en) 2011-10-28
UA68366C2 (en) 2004-08-16
CR5936A (es) 2006-08-18
EE04440B1 (et) 2005-02-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20121222