DE69831176D1 - Kappa rezeptor opioid peptide - Google Patents

Kappa rezeptor opioid peptide

Info

Publication number
DE69831176D1
DE69831176D1 DE69831176T DE69831176T DE69831176D1 DE 69831176 D1 DE69831176 D1 DE 69831176D1 DE 69831176 T DE69831176 T DE 69831176T DE 69831176 T DE69831176 T DE 69831176T DE 69831176 D1 DE69831176 D1 DE 69831176D1
Authority
DE
Germany
Prior art keywords
opioid peptide
kappa receptor
receptor opioid
kappa
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831176T
Other languages
English (en)
Other versions
DE69831176T2 (de
Inventor
Louis Junien
J Riviere
D Schteingart
Sueiras Diaz
A Trojnar
W Vanderah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cara Therapeutics Inc
Original Assignee
Cara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc filed Critical Cara Therapeutics Inc
Application granted granted Critical
Publication of DE69831176D1 publication Critical patent/DE69831176D1/de
Publication of DE69831176T2 publication Critical patent/DE69831176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69831176T 1997-12-23 1998-12-22 Kappa rezeptor opioid peptide Expired - Lifetime DE69831176T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
US997208 1997-12-23
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
DE69831176D1 true DE69831176D1 (de) 2005-09-15
DE69831176T2 DE69831176T2 (de) 2006-04-20

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831176T Expired - Lifetime DE69831176T2 (de) 1997-12-23 1998-12-22 Kappa rezeptor opioid peptide

Country Status (33)

Country Link
US (1) US5965701A (de)
EP (1) EP1042359B1 (de)
JP (1) JP4275852B2 (de)
KR (1) KR100629548B1 (de)
CN (1) CN1154655C (de)
AR (1) AR014167A1 (de)
AT (1) ATE301670T1 (de)
AU (1) AU747806B2 (de)
BR (2) BR9814499B1 (de)
CA (1) CA2315878C (de)
CR (1) CR5936A (de)
CZ (1) CZ297281B6 (de)
DE (1) DE69831176T2 (de)
DK (1) DK1042359T3 (de)
EE (1) EE04440B1 (de)
ES (1) ES2247735T3 (de)
HK (1) HK1029349A1 (de)
HR (1) HRP20000415B1 (de)
HU (1) HU227640B1 (de)
IL (3) IL136742A0 (de)
MY (1) MY117542A (de)
NO (1) NO327080B1 (de)
NZ (1) NZ505183A (de)
PL (1) PL195842B1 (de)
PT (1) PT1042359E (de)
RU (1) RU2217437C2 (de)
SK (1) SK286135B6 (de)
TR (1) TR200001985T2 (de)
TW (1) TW580502B (de)
UA (1) UA68366C2 (de)
UY (1) UY25327A1 (de)
WO (1) WO1999032510A1 (de)
ZA (1) ZA9811801B (de)

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DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
WO2002089845A1 (en) * 2001-05-08 2002-11-14 Toray Industries, Inc. Remedies for sepsis
AU2003220125B2 (en) 2002-03-20 2006-06-15 Mannkind Corporation Inhalation apparatus
BRPI0514263B8 (pt) 2004-08-20 2021-05-25 Mannkind Corp método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida
EP1791542B1 (de) 2004-08-23 2015-05-20 Mannkind Corporation Diketopiperazinsalze für die arzneiabgabe
DK2656836T3 (en) 2005-09-14 2017-10-23 Mannkind Corp Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
JP5599975B2 (ja) 2006-02-22 2014-10-01 マンカインド コーポレイション ジケトピペラジン及び活性薬剤を含有する微粒子の製剤特性の改善方法
CA2653072A1 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
JP2009538316A (ja) * 2006-05-26 2009-11-05 カラ セラピューティクス インコーポレイテッド κオピオイド受容体ペプチドのＮ−オキシド
NZ577107A (en) 2006-11-10 2012-01-12 Cara Therapeutics Inc Synthetic peptide amide ligands of the kappa opiod receptor
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY172371A (en) 2008-06-13 2019-11-21 Mannkind Corp A dry powder inhaler and system for drug delivery
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
JP6385673B2 (ja) 2010-06-21 2018-09-05 マンカインド コーポレイション 乾燥粉末薬物送達システム
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
BR112015000529B1 (pt) 2012-07-12 2022-01-11 Mannkind Corporation Inalador de pó seco
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
CN108578372B (zh) 2013-03-15 2021-07-06 曼金德公司 微晶二酮哌嗪组合物以及方法
MX2016000739A (es) 2013-07-18 2017-04-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CN106459150B (zh) * 2014-06-26 2020-01-24 丸石制药株式会社 合成五肽的制造方法
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10550150B2 (en) 2015-05-11 2020-02-04 Cadila Healthcare Limited Short-chain peptides as Kappa (κ) opioid receptors (KOR) agonist
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
JP6794602B2 (ja) 2016-09-27 2020-12-02 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ポリアミド化合物及びその使用
EP3656782B1 (de) * 2017-07-21 2021-12-22 Sichuan Haisco Pharmaceutical Co., Ltd. Peptidamidverbindung und verfahren zu ihrer herstellung und ihre medizinische verwendung
US11180530B2 (en) 2017-12-06 2021-11-23 Jiangsu Hengrui Medicine Co., Ltd. Salt of phenylpropionamide derivative and preparation method therefor
CN111148526B (zh) 2018-05-16 2023-03-10 江苏恒瑞医药股份有限公司 一种kor受体激动剂药物组合物
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
CA3180729A1 (en) 2020-06-25 2021-12-30 Subo Liao Peptides for treatment of medical disorders
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US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
UA68366C2 (en) 2004-08-16
CN1154655C (zh) 2004-06-23
AU747806B2 (en) 2002-05-23
TW580502B (en) 2004-03-21
IL136742A0 (en) 2001-06-14
WO1999032510A9 (en) 1999-09-23
CZ20002382A3 (cs) 2000-12-13
WO1999032510A1 (en) 1999-07-01
NO20003245D0 (no) 2000-06-21
PL341308A1 (en) 2001-04-09
JP4275852B2 (ja) 2009-06-10
SK286135B6 (sk) 2008-04-07
EP1042359A1 (de) 2000-10-11
CR5936A (es) 2006-08-18
IL178471A0 (en) 2007-02-11
ZA9811801B (en) 1999-06-22
US5965701A (en) 1999-10-12
BR9814499A (pt) 2000-10-10
EP1042359B1 (de) 2005-08-10
DK1042359T3 (da) 2005-11-28
EE200000370A (et) 2001-10-15
NO20003245L (no) 2000-08-23
CA2315878A1 (en) 1999-07-01
DE69831176T2 (de) 2006-04-20
ATE301670T1 (de) 2005-08-15
AR014167A1 (es) 2001-02-07
HRP20000415B1 (en) 2004-06-30
UY25327A1 (es) 2000-12-29
EE04440B1 (et) 2005-02-15
PL195842B1 (pl) 2007-10-31
HK1029349A1 (en) 2001-03-30
HRP20000415A2 (en) 2000-12-31
BR9814499B1 (pt) 2014-10-21
IL136742A (en) 2006-12-31
HU227640B1 (en) 2011-10-28
BRPI9814499A (pt) 2000-10-10
NO327080B1 (no) 2009-04-20
RU2217437C2 (ru) 2003-11-27
SK9602000A3 (en) 2001-01-18
BRPI9814499B8 (pt) 2021-11-09
CA2315878C (en) 2010-11-16
PT1042359E (pt) 2005-11-30
AU1940299A (en) 1999-07-12
NZ505183A (en) 2001-09-28
ES2247735T3 (es) 2006-03-01
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
TR200001985T2 (tr) 2000-11-21
JP2001526295A (ja) 2001-12-18
HUP0100626A3 (en) 2001-12-28
CN1283201A (zh) 2001-02-07
MY117542A (en) 2004-07-31
BRPI9814499B1 (pt) 2014-10-21
KR20010033450A (ko) 2001-04-25
KR100629548B1 (ko) 2006-09-27

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Legal Events

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8364 No opposition during term of opposition