HRP20000415B1 - Kappa receptor opioid peptides - Google Patents

Kappa receptor opioid peptides

Info

Publication number
HRP20000415B1
HRP20000415B1 HR20000415A HRP20000415A HRP20000415B1 HR P20000415 B1 HRP20000415 B1 HR P20000415B1 HR 20000415 A HR20000415 A HR 20000415A HR P20000415 A HRP20000415 A HR P20000415A HR P20000415 B1 HRP20000415 B1 HR P20000415B1
Authority
HR
Croatia
Prior art keywords
opioid peptides
kappa receptor
receptor opioid
kappa
peptides
Prior art date
Application number
HR20000415A
Inventor
Junien Jean Louis
Pierre J M Riviere
Claudio D Schteingart
Javier Sueiras Diaz
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of HRP20000415A2 publication Critical patent/HRP20000415A2/en
Publication of HRP20000415B1 publication Critical patent/HRP20000415B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20000415A 1997-12-23 2000-06-20 Kappa receptor opioid peptides HRP20000415B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
HRP20000415A2 HRP20000415A2 (en) 2000-12-31
HRP20000415B1 true HRP20000415B1 (en) 2004-06-30

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000415A HRP20000415B1 (en) 1997-12-23 2000-06-20 Kappa receptor opioid peptides

Country Status (33)

Country Link
US (1) US5965701A (en)
EP (1) EP1042359B1 (en)
JP (1) JP4275852B2 (en)
KR (1) KR100629548B1 (en)
CN (1) CN1154655C (en)
AR (1) AR014167A1 (en)
AT (1) ATE301670T1 (en)
AU (1) AU747806B2 (en)
BR (2) BRPI9814499B8 (en)
CA (1) CA2315878C (en)
CR (1) CR5936A (en)
CZ (1) CZ297281B6 (en)
DE (1) DE69831176T2 (en)
DK (1) DK1042359T3 (en)
EE (1) EE04440B1 (en)
ES (1) ES2247735T3 (en)
HK (1) HK1029349A1 (en)
HR (1) HRP20000415B1 (en)
HU (1) HU227640B1 (en)
IL (3) IL136742A0 (en)
MY (1) MY117542A (en)
NO (1) NO327080B1 (en)
NZ (1) NZ505183A (en)
PL (1) PL195842B1 (en)
PT (1) PT1042359E (en)
RU (1) RU2217437C2 (en)
SK (1) SK286135B6 (en)
TR (1) TR200001985T2 (en)
TW (1) TW580502B (en)
UA (1) UA68366C2 (en)
UY (1) UY25327A1 (en)
WO (1) WO1999032510A1 (en)
ZA (1) ZA9811801B (en)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (en) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa opiate agonists for the treatment of diseases of the bladder
WO2002089845A1 (en) * 2001-05-08 2002-11-14 Toray Industries, Inc. Remedies for sepsis
ES2300568T3 (en) 2002-03-20 2008-06-16 Mannkind Corporation INHALATION APPARATUS
MX2007001903A (en) 2004-08-20 2007-08-02 Mannkind Corp Catalysis of diketopiperazine synthesis.
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
CA2621806C (en) 2005-09-14 2016-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN101389348A (en) 2006-02-22 2009-03-18 曼金德公司 A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007139921A2 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
JP2009538310A (en) * 2006-05-26 2009-11-05 カラ セラピューティクス インコーポレイテッド Methods for raising prolactin in mammals
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
RU2500685C2 (en) * 2006-11-10 2013-12-10 Кара Терапеутикс, Инк Synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
ES2421385T3 (en) 2008-06-20 2013-09-02 Mannkind Corp Interactive device and procedure to establish the profile, in real time, of inhalation efforts
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
ES2943333T3 (en) 2009-06-12 2023-06-12 Mannkind Corp Diketopiperazine microparticles with defined surface areas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
CN105667994B (en) 2011-04-01 2018-04-06 曼金德公司 Blister package for pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (en) * 2011-10-24 2014-08-01 맨카인드 코포레이션 Methods and compositions for treating pain
CN104619369B (en) 2012-07-12 2018-01-30 曼金德公司 Dry-powder medicament induction system and method
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
CN114848614A (en) 2013-07-18 2022-08-05 曼金德公司 Heat stable dry powder pharmaceutical compositions and methods
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN106459150B (en) * 2014-06-26 2020-01-24 丸石制药株式会社 Method for producing synthetic pentapeptide
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6651546B2 (en) * 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド Novel short-chain peptides as kappa (κ) opioid receptor (KOR) agonists
CN107098876B (en) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 Phenyl propionamide derivative, preparation method and medical application thereof
CN109563133B (en) * 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 Polyamide compound and use thereof
MY200925A (en) 2017-07-21 2024-01-24 Sichuan Haisco Pharmaceutical Co Ltd Peptide Amide Compound and Preparation Method and Medical use Thereof
UA126005C2 (en) 2017-12-06 2022-07-27 Цзянсу Хенжуй Медісін Ко., Лтд. Salt of phenylpropionamide derivative and preparation method therefor
CN111148526B (en) 2018-05-16 2023-03-10 江苏恒瑞医药股份有限公司 Pharmaceutical composition of KOR receptor agonist
WO2021013085A1 (en) * 2019-07-25 2021-01-28 四川海思科制药有限公司 Peptide amide salt, preparation method therefor and use thereof in medicine
CN114127086B (en) * 2019-07-25 2023-10-20 四川海思科制药有限公司 Deuterated peptide amide compound and preparation method and medical application thereof
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
AU2020454871A1 (en) 2020-06-25 2023-01-19 Humanwell Pharmaceutical US Peptides for treatment of medical disorders
TW202317533A (en) 2021-07-02 2023-05-01 美商雅斯治療公司 Solid forms of osanetant

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GB2013689B (en) * 1977-12-15 1982-03-24 Reckitt & Colmann Prod Ltd Compounds
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
US5965701A (en) 1999-10-12
DK1042359T3 (en) 2005-11-28
HK1029349A1 (en) 2001-03-30
EE04440B1 (en) 2005-02-15
KR100629548B1 (en) 2006-09-27
CZ20002382A3 (en) 2000-12-13
CR5936A (en) 2006-08-18
IL136742A (en) 2006-12-31
DE69831176T2 (en) 2006-04-20
NZ505183A (en) 2001-09-28
ATE301670T1 (en) 2005-08-15
CZ297281B6 (en) 2006-10-11
WO1999032510A9 (en) 1999-09-23
BRPI9814499B1 (en) 2014-10-21
SK286135B6 (en) 2008-04-07
NO20003245D0 (en) 2000-06-21
CA2315878A1 (en) 1999-07-01
BR9814499A (en) 2000-10-10
CN1283201A (en) 2001-02-07
AU1940299A (en) 1999-07-12
HU227640B1 (en) 2011-10-28
PT1042359E (en) 2005-11-30
SK9602000A3 (en) 2001-01-18
RU2217437C2 (en) 2003-11-27
BRPI9814499B8 (en) 2021-11-09
NO327080B1 (en) 2009-04-20
JP2001526295A (en) 2001-12-18
EP1042359A1 (en) 2000-10-11
PL341308A1 (en) 2001-04-09
HUP0100626A3 (en) 2001-12-28
NO20003245L (en) 2000-08-23
BRPI9814499A (en) 2000-10-10
ZA9811801B (en) 1999-06-22
DE69831176D1 (en) 2005-09-15
JP4275852B2 (en) 2009-06-10
UY25327A1 (en) 2000-12-29
KR20010033450A (en) 2001-04-25
PL195842B1 (en) 2007-10-31
ES2247735T3 (en) 2006-03-01
TR200001985T2 (en) 2000-11-21
HUP0100626A2 (en) 2001-08-28
EE200000370A (en) 2001-10-15
AU747806B2 (en) 2002-05-23
CN1154655C (en) 2004-06-23
MY117542A (en) 2004-07-31
BR9814499B1 (en) 2014-10-21
HRP20000415A2 (en) 2000-12-31
IL136742A0 (en) 2001-06-14
TW580502B (en) 2004-03-21
CA2315878C (en) 2010-11-16
IL178471A0 (en) 2007-02-11
AR014167A1 (en) 2001-02-07
UA68366C2 (en) 2004-08-16
WO1999032510A1 (en) 1999-07-01
EP1042359B1 (en) 2005-08-10

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Legal Events

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A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: CARA THERAPEUTICS, INC., US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20111213

Year of fee payment: 14

PBON Lapse due to non-payment of renewal fee

Effective date: 20121223