ZA200504898B - Acyclic pyrazole compounds - Google Patents
Acyclic pyrazole compounds Download PDFInfo
- Publication number
- ZA200504898B ZA200504898B ZA200504898A ZA200504898A ZA200504898B ZA 200504898 B ZA200504898 B ZA 200504898B ZA 200504898 A ZA200504898 A ZA 200504898A ZA 200504898 A ZA200504898 A ZA 200504898A ZA 200504898 B ZA200504898 B ZA 200504898B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- heteroaryl
- carbon
- Prior art date
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- -1 Acyclic pyrazole compounds Chemical class 0.000 title claims description 322
- 229910052799 carbon Inorganic materials 0.000 claims description 334
- 125000000217 alkyl group Chemical group 0.000 claims description 302
- 125000003118 aryl group Chemical group 0.000 claims description 290
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 226
- 125000000623 heterocyclic group Chemical group 0.000 claims description 219
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 214
- 125000001072 heteroaryl group Chemical group 0.000 claims description 214
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 192
- 150000001875 compounds Chemical class 0.000 claims description 180
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 152
- 125000002950 monocyclic group Chemical group 0.000 claims description 149
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 146
- 229910052757 nitrogen Inorganic materials 0.000 claims description 137
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 134
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 111
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 107
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 83
- 230000002401 inhibitory effect Effects 0.000 claims description 79
- 208000035475 disorder Diseases 0.000 claims description 76
- 229910052717 sulfur Inorganic materials 0.000 claims description 74
- 125000003342 alkenyl group Chemical group 0.000 claims description 72
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
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- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 32
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US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
US5565448A (en) * | 1992-02-24 | 1996-10-15 | Smithkline Beecham Corporation | Medicament |
NZ262664A (en) * | 1993-02-22 | 1997-04-24 | Merck & Co Inc | Heterocyclic substituted derivatives, and medicaments thereof |
JP3714685B2 (ja) * | 1994-05-18 | 2005-11-09 | 第一サントリーファーマ株式会社 | ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体 |
US5616577A (en) * | 1994-08-25 | 1997-04-01 | Smithkline Beecham Corporation | Protein Kinase C inhibitor |
US5591740A (en) * | 1995-06-07 | 1997-01-07 | Osteoarthritis Sciences, Incorporated | Use of debromohymenialdisine for treating osteoarthritis |
US6008204A (en) * | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
JP2000510327A (ja) * | 1996-03-12 | 2000-08-15 | スミスクライン・ビーチャム・コーポレイション | 医薬的に活性な化合物の同定方法 |
AU3044197A (en) * | 1996-07-11 | 1998-02-09 | Pfizer Inc. | Pyridylpyrrole compounds useful as interleukin- and tnf antagonists |
US6096753A (en) * | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
US6489325B1 (en) * | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
WO1999001452A1 (en) * | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
WO1999003498A1 (en) * | 1997-07-18 | 1999-01-28 | Novo Nordisk A/S | USE OF FVIIa OR FVIIai FOR THE TREATMENT OF ADVERSE CONDITIONS RELATED TO THE FVIIa MEDIATED INTRACELLULAR SIGNALLING PATHWAY |
US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
WO1999032121A1 (en) * | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
US6197954B1 (en) * | 1998-01-30 | 2001-03-06 | The Trustees Of Columbia University In The City Of New York | Intermediates for the synthesis of debromohymenialdisine and processes thereof |
AU772477B2 (en) * | 1998-08-28 | 2004-04-29 | Scios Inc. | Inhibitors of p38-alpha kinase |
DE69915862T2 (de) * | 1998-11-20 | 2004-08-05 | G.D. Searle Llc | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
AU760039B2 (en) * | 1998-12-17 | 2003-05-08 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of JNK protein kinases |
EP1140083A4 (en) * | 1999-01-08 | 2004-01-02 | Smithkline Beecham Corp | NEW CONNECTIONS |
US6211361B1 (en) * | 1999-07-20 | 2001-04-03 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon, State Univeristy | Method for making debromohymenialdisine and analogs thereof |
NZ514583A (en) * | 2000-02-05 | 2004-05-28 | Vertex Pharma | Pyrazole compositions useful as inhibitors of ERK |
RU2270194C2 (ru) * | 2000-05-22 | 2006-02-20 | Лео Фарма А/С | Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения |
-
2003
- 2003-12-19 JP JP2004563888A patent/JP2006514043A/ja not_active Withdrawn
- 2003-12-19 AU AU2003301226A patent/AU2003301226A1/en not_active Withdrawn
- 2003-12-19 RU RU2005119173/04A patent/RU2005119173A/ru not_active Application Discontinuation
- 2003-12-19 AU AU2003297431A patent/AU2003297431A1/en not_active Abandoned
- 2003-12-19 KR KR1020057011474A patent/KR20050104339A/ko not_active Application Discontinuation
- 2003-12-19 WO PCT/US2003/040811 patent/WO2004058762A1/en not_active Application Discontinuation
- 2003-12-19 PL PL377461A patent/PL377461A1/pl unknown
- 2003-12-19 MX MXPA05006569A patent/MXPA05006569A/es unknown
- 2003-12-19 BR BR0317430-1A patent/BR0317430A/pt not_active Application Discontinuation
- 2003-12-19 US US10/742,494 patent/US20040152739A1/en not_active Abandoned
- 2003-12-19 CA CA002509565A patent/CA2509565A1/en not_active Abandoned
- 2003-12-19 CN CNA2003801096266A patent/CN1747949A/zh active Pending
- 2003-12-19 US US10/742,072 patent/US20040209897A1/en not_active Abandoned
- 2003-12-19 EP EP03814268A patent/EP1572693A1/en not_active Withdrawn
- 2003-12-19 JP JP2004563946A patent/JP2006511583A/ja not_active Withdrawn
- 2003-12-19 BR BR0317525-1A patent/BR0317525A/pt not_active IP Right Cessation
- 2003-12-19 WO PCT/US2003/040932 patent/WO2004058176A2/en active Application Filing
- 2003-12-19 CA CA002510298A patent/CA2510298A1/en not_active Abandoned
- 2003-12-19 ZA ZA200504898A patent/ZA200504898B/en unknown
- 2003-12-19 EP EP03814309A patent/EP1572682A4/en not_active Withdrawn
- 2003-12-19 MX MXPA05006568A patent/MXPA05006568A/es not_active Application Discontinuation
-
2005
- 2005-06-15 IL IL169177A patent/IL169177A0/en unknown
- 2005-07-13 NO NO20053396A patent/NO20053396L/no not_active Application Discontinuation
-
2007
- 2007-12-17 US US11/958,229 patent/US20080113971A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040152739A1 (en) | 2004-08-05 |
EP1572682A4 (en) | 2008-01-23 |
EP1572682A2 (en) | 2005-09-14 |
AU2003297431A1 (en) | 2004-07-22 |
US20080113971A1 (en) | 2008-05-15 |
IL169177A0 (en) | 2007-07-04 |
NO20053396L (no) | 2005-09-12 |
EP1572693A1 (en) | 2005-09-14 |
CA2510298A1 (en) | 2004-07-15 |
NO20053396D0 (no) | 2005-07-13 |
JP2006514043A (ja) | 2006-04-27 |
MXPA05006568A (es) | 2005-09-22 |
MXPA05006569A (es) | 2005-09-22 |
WO2004058176A2 (en) | 2004-07-15 |
RU2005119173A (ru) | 2006-02-27 |
WO2004058176A3 (en) | 2004-09-16 |
JP2006511583A (ja) | 2006-04-06 |
CA2509565A1 (en) | 2004-07-15 |
BR0317525A (pt) | 2005-11-16 |
CN1747949A (zh) | 2006-03-15 |
AU2003301226A2 (en) | 2004-07-22 |
AU2003301226A1 (en) | 2004-07-22 |
US20040209897A1 (en) | 2004-10-21 |
KR20050104339A (ko) | 2005-11-02 |
BR0317430A (pt) | 2005-10-25 |
PL377461A1 (pl) | 2006-02-06 |
WO2004058762A1 (en) | 2004-07-15 |
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