PE20080668A1 - Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno - Google Patents
Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogenoInfo
- Publication number
- PE20080668A1 PE20080668A1 PE2007001155A PE2007001155A PE20080668A1 PE 20080668 A1 PE20080668 A1 PE 20080668A1 PE 2007001155 A PE2007001155 A PE 2007001155A PE 2007001155 A PE2007001155 A PE 2007001155A PE 20080668 A1 PE20080668 A1 PE 20080668A1
- Authority
- PE
- Peru
- Prior art keywords
- protein kinase
- activated protein
- amino
- alkyl
- inhibitors
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE R1 ES HALOGENO, CN, HIDROXILO, MERCAPTO, ENTRE OTROS; X ES O, S O NOH; R2 ES -C(A)(Q)-Y EN DONDE Q ES H O ALQUILO(C1-C6); A ES H O ALQUILO(C1-C6); Y ES AMINO, AMINO-OXILO, HIDROXILO, ALCOXILO(C1-C6), ENTRE OTROS; R3 ES -OH, -OR4 O -NHR4 DONDE R4 ES H O ALQUILO(C1-C6); O R2 Y R3 SE UNEN PARA FORMAR UN ANILLO DE 5 A 7 MIEMBROS; R7 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON AMINO, HIDROXILO, HALOGENO O CARBOXILO. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DEL ACIDO 2-AMINO-METIL-8-((E)-ESTIRIL)-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, 2-((E)-ESTIRIL)-9,10-DIHIDRO-8H-3,8,10-TRIAZA-PENTALEN-[2,1-a]-NAFTALEN-7-ONA, CLORHIDRATO DEL ACIDO 2-AMINO-METIL-8-CLORO-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA-2 DE PROTEINA ACTIVADA POR CINASA DE PROTEINA ACTIVADA POR MITOGENO (MAPKAPK2) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ANEMIA HEMOLITICA, ESPONDILITIS ANQUILOSANTE, GASTRITIS, LUPUS ERITEMATOSO SISTEMICO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06119817 | 2006-08-30 |
Publications (1)
Publication Number | Publication Date |
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PE20080668A1 true PE20080668A1 (es) | 2008-07-17 |
Family
ID=37836874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2007001155A PE20080668A1 (es) | 2006-08-30 | 2007-08-27 | Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100069360A1 (es) |
EP (1) | EP2064212A1 (es) |
JP (1) | JP2010501605A (es) |
KR (1) | KR20090046891A (es) |
CN (1) | CN101506208A (es) |
AR (1) | AR062564A1 (es) |
AU (1) | AU2007291575B2 (es) |
BR (1) | BRPI0716198A2 (es) |
CA (1) | CA2660980A1 (es) |
CL (1) | CL2007002511A1 (es) |
MX (1) | MX2009002278A (es) |
PE (1) | PE20080668A1 (es) |
RU (1) | RU2009111382A (es) |
TW (1) | TW200819449A (es) |
WO (1) | WO2008025512A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2007002499A1 (es) | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
WO2009067493A2 (en) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
US8217064B2 (en) | 2007-12-20 | 2012-07-10 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
US8580793B2 (en) | 2009-03-20 | 2013-11-12 | Nerviano Medical Services S.R.L. | Use of kinase inhibitor for the treatment of thymoma |
BR112014005104A2 (pt) | 2011-09-02 | 2017-07-04 | Salk Inst For Biological Studi | inibidores camkii, ip3r, calcineurin, p38 e mk2/3 para tratar atar distúrbios metabólicos de obesidade |
JP2016518316A (ja) | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Mk2阻害剤およびそれらの使用 |
EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
CN104140393B (zh) * | 2013-12-10 | 2016-09-21 | 郑州泰基鸿诺医药股份有限公司 | 一种芳环/芳杂环叔丁醇酯类化合物的制备方法 |
CN107082780B (zh) * | 2017-04-14 | 2020-08-14 | 山东省医学科学院药物研究所 | 一种具有吡咯骈异喹啉结构的生物碱及其制备方法与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05006569A (es) * | 2002-12-20 | 2005-09-22 | Pharmacia Corp | Compuestos que inhiben la proteina cinasa-2 activada por la proteina cinasa activada por el mitogeno. |
US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
-
2007
- 2007-08-27 PE PE2007001155A patent/PE20080668A1/es not_active Application Discontinuation
- 2007-08-28 AR ARP070103811A patent/AR062564A1/es unknown
- 2007-08-28 MX MX2009002278A patent/MX2009002278A/es not_active Application Discontinuation
- 2007-08-28 AU AU2007291575A patent/AU2007291575B2/en not_active Expired - Fee Related
- 2007-08-28 CN CNA2007800310152A patent/CN101506208A/zh active Pending
- 2007-08-28 RU RU2009111382/04A patent/RU2009111382A/ru not_active Application Discontinuation
- 2007-08-28 CA CA002660980A patent/CA2660980A1/en not_active Abandoned
- 2007-08-28 WO PCT/EP2007/007510 patent/WO2008025512A1/en active Application Filing
- 2007-08-28 EP EP07801933A patent/EP2064212A1/en not_active Withdrawn
- 2007-08-28 BR BRPI0716198-0A2A patent/BRPI0716198A2/pt not_active IP Right Cessation
- 2007-08-28 US US12/439,603 patent/US20100069360A1/en not_active Abandoned
- 2007-08-28 JP JP2009525966A patent/JP2010501605A/ja active Pending
- 2007-08-28 KR KR1020097004142A patent/KR20090046891A/ko not_active Application Discontinuation
- 2007-08-29 TW TW096132111A patent/TW200819449A/zh unknown
- 2007-08-29 CL CL200702511A patent/CL2007002511A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2064212A1 (en) | 2009-06-03 |
MX2009002278A (es) | 2009-03-20 |
JP2010501605A (ja) | 2010-01-21 |
RU2009111382A (ru) | 2010-10-10 |
AU2007291575A1 (en) | 2008-03-06 |
AU2007291575B2 (en) | 2011-02-10 |
KR20090046891A (ko) | 2009-05-11 |
AR062564A1 (es) | 2008-11-19 |
CL2007002511A1 (es) | 2008-05-16 |
CA2660980A1 (en) | 2008-03-06 |
WO2008025512A1 (en) | 2008-03-06 |
TW200819449A (en) | 2008-05-01 |
CN101506208A (zh) | 2009-08-12 |
BRPI0716198A2 (pt) | 2013-11-12 |
US20100069360A1 (en) | 2010-03-18 |
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