CN113661164A - 一种cdk激酶抑制剂及其应用 - Google Patents

一种cdk激酶抑制剂及其应用 Download PDF

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Publication number
CN113661164A
CN113661164A CN202080000675.XA CN202080000675A CN113661164A CN 113661164 A CN113661164 A CN 113661164A CN 202080000675 A CN202080000675 A CN 202080000675A CN 113661164 A CN113661164 A CN 113661164A
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alkyl
heterocycloalkyl
cycloalkyl
heterocycloaryl
straight
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林星雨
陆婷婷
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Zhuhai Woo Biological Science And Technology Co ltd
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Zhuhai Woo Biological Science And Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种通式为Ⅰ的化合物，或其药学上可接受的盐、立体异构体、酯、前药、溶剂化物和氘代化合物，及其含有通式为Ⅰ的化合物的组合物，以及通式为Ⅰ的化合物，或其药学上可接受的盐、立体异构体、酯、前药、溶剂化物和氘代化合物在制备治疗一种或多种细胞周期蛋白依赖激酶相关的疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN202080000675.XA 2019-04-08 2020-03-26 一种cdk激酶抑制剂及其应用 Pending CN113661164A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019102770367 2019-04-08
CN201910277036 2019-04-08
PCT/CN2020/081432 WO2020207260A1 (zh) 2019-04-08 2020-03-26 一种cdk激酶抑制剂及其应用

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CN113661164A true CN113661164A (zh) 2021-11-16

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CN202080000675.XA Pending CN113661164A (zh) 2019-04-08 2020-03-26 一种cdk激酶抑制剂及其应用

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CN (1) CN113661164A (zh)
WO (1) WO2020207260A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3728228A1 (en) 2017-12-22 2020-10-28 Ravenna Pharmaceuticals, Inc. Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
JP2023554643A (ja) * 2020-12-18 2023-12-28 プレリュード・セラピューティクス・インコーポレイテッド Ｃｄｋ阻害剤及び医薬としてのその使用
US20230257394A1 (en) * 2022-02-03 2023-08-17 Prelude Therapeutics, Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
WO2024125451A1 (en) * 2022-12-11 2024-06-20 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Piperindin-ones derivatives, preparation methods and medicinal uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058762A1 (en) * 2002-12-20 2004-07-15 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
WO2005014572A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2009040399A1 (en) * 2007-09-28 2009-04-02 Nerviano Medical Sciences S.R.L. Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058762A1 (en) * 2002-12-20 2004-07-15 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
WO2005014572A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2009040399A1 (en) * 2007-09-28 2009-04-02 Nerviano Medical Sciences S.R.L. Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ERMES VANOTTI ET AL.: "Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships" *
HONGBING HUANG ET AL.: "Structure-Based Design of Potent and Selective CK1γ Inhibitors" *
MICHELE CARUSO ET AL.: "5-(2-Amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors" *
RICHARD O. ODUOR ET AL.: "Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads" *

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