ZA200005796B - Imidazo pyridine derivatives which inhibit gastric acid secretion. - Google Patents
Imidazo pyridine derivatives which inhibit gastric acid secretion. Download PDFInfo
- Publication number
- ZA200005796B ZA200005796B ZA200005796A ZA200005796A ZA200005796B ZA 200005796 B ZA200005796 B ZA 200005796B ZA 200005796 A ZA200005796 A ZA 200005796A ZA 200005796 A ZA200005796 A ZA 200005796A ZA 200005796 B ZA200005796 B ZA 200005796B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- compound
- formula
- alkoxy
- ethyl
- Prior art date
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- 230000027119 gastric acid secretion Effects 0.000 title claims description 10
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 140
- 150000001875 compounds Chemical class 0.000 claims description 115
- -1 imidazotyl Chemical group 0.000 claims description 31
- 229910052736 halogen Inorganic materials 0.000 claims description 28
- 150000002367 halogens Chemical class 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 20
- 238000011282 treatment Methods 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 15
- 125000004076 pyridyl group Chemical group 0.000 claims description 15
- 125000001624 naphthyl group Chemical group 0.000 claims description 14
- 125000002883 imidazolyl group Chemical group 0.000 claims description 13
- 125000001041 indolyl group Chemical group 0.000 claims description 13
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 12
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- 230000008569 process Effects 0.000 claims description 11
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims description 10
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
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- 241000282414 Homo sapiens Species 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 9
- 125000002541 furyl group Chemical group 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 125000001544 thienyl group Chemical group 0.000 claims description 9
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- 241000590002 Helicobacter pylori Species 0.000 claims description 5
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- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 5
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- 210000001156 gastric mucosa Anatomy 0.000 claims description 5
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- CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims description 5
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
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- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims description 4
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
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- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 3
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- VNHBYKHXBCYPBJ-UHFFFAOYSA-N 5-ethynylimidazo[1,2-a]pyridine Chemical compound C#CC1=CC=CC2=NC=CN12 VNHBYKHXBCYPBJ-UHFFFAOYSA-N 0.000 claims description 2
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
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- 230000002401 inhibitory effect Effects 0.000 claims 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9801526A SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200005796B true ZA200005796B (en) | 2002-01-18 |
Family
ID=20411154
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200005796A ZA200005796B (en) | 1998-04-29 | 2000-10-18 | Imidazo pyridine derivatives which inhibit gastric acid secretion. |
| ZA200005797A ZA200005797B (en) | 1998-04-29 | 2000-10-18 | Imidazo pyridine derivatives which inhibit gastric acid secretion. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200005797A ZA200005797B (en) | 1998-04-29 | 2000-10-18 | Imidazo pyridine derivatives which inhibit gastric acid secretion. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6313136B1 (xx) |
| EP (4) | EP1491542B1 (xx) |
| JP (2) | JP3883383B2 (xx) |
| KR (3) | KR100595806B1 (xx) |
| CN (2) | CN1165535C (xx) |
| AR (2) | AR015769A1 (xx) |
| AT (4) | ATE372340T1 (xx) |
| AU (2) | AU769190B2 (xx) |
| BR (2) | BR9909996B1 (xx) |
| CA (2) | CA2329921A1 (xx) |
| CZ (2) | CZ292567B6 (xx) |
| DE (4) | DE69927803T2 (xx) |
| DK (2) | DK1073656T3 (xx) |
| EE (2) | EE04916B1 (xx) |
| ES (2) | ES2252975T3 (xx) |
| HK (5) | HK1033457A1 (xx) |
| HU (2) | HUP0102425A3 (xx) |
| ID (2) | ID27530A (xx) |
| IL (4) | IL139200A0 (xx) |
| IS (2) | IS5684A (xx) |
| MY (2) | MY121389A (xx) |
| NO (2) | NO317262B1 (xx) |
| NZ (2) | NZ507638A (xx) |
| PL (2) | PL195000B1 (xx) |
| RU (2) | RU2235725C2 (xx) |
| SA (2) | SA99200064B1 (xx) |
| SE (1) | SE9801526D0 (xx) |
| SI (1) | SI1073656T1 (xx) |
| SK (2) | SK285768B6 (xx) |
| TR (4) | TR200003149T2 (xx) |
| TW (2) | TWI250159B (xx) |
| UA (2) | UA67769C2 (xx) |
| WO (2) | WO1999055706A1 (xx) |
| ZA (2) | ZA200005796B (xx) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| SE0003186D0 (sv) * | 2000-09-07 | 2000-09-07 | Astrazeneca Ab | New process |
| US6900324B2 (en) | 2000-09-07 | 2005-05-31 | Astrazeneca Ab | Process for preparing a substituted imidazopyridine compound |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| SE0100295D0 (sv) * | 2001-02-01 | 2001-02-01 | Astrazeneca Ab | New compounds |
| SE0100296D0 (sv) * | 2001-02-01 | 2001-02-01 | Astrazeneca Ab | New compounds |
| SE0100297D0 (sv) * | 2001-02-01 | 2001-02-01 | Astrazeneca Ab | New compounds |
| CA2434835A1 (en) * | 2001-02-13 | 2002-08-22 | Astrazeneca Ab | Novel modified released formulation |
| MXPA03007888A (es) * | 2001-03-08 | 2003-12-04 | Astrazeneca Ab | Compuestos para tratamiento y prevencion de ulcera gastrica inducida por medicamentos. |
| SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| SE0201940D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination II |
| SE0201939D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination |
| TWI351405B (en) | 2002-09-19 | 2011-11-01 | Schering Corp | Novel imidazopyridines as cyclin dependent kinase |
| MXPA05005117A (es) | 2002-11-19 | 2005-07-01 | Altana Pharma Ag | Imidazopiridinas 8-sustituidas. |
| AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
| DK1603570T5 (da) | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
| CA2503290C (en) | 2003-03-10 | 2012-12-04 | Altana Pharma Ag | Novel process for the preparation of roflumilast |
| SE525349C2 (sv) * | 2003-06-23 | 2005-02-08 | Volvo Penta Ab | Utombordsdrev för båtar |
| SE0301904D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
| SE0301905D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound I with therapeutic effect |
| SE0301903D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound III with therapeutic effect |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CN1874772A (zh) * | 2003-11-03 | 2006-12-06 | 阿斯利康(瑞典)有限公司 | 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物 |
| SE0303451D0 (sv) * | 2003-12-18 | 2003-12-18 | Astrazeneca Ab | New compounds |
| WO2005070927A2 (en) * | 2004-01-26 | 2005-08-04 | Altana Pharma Ag | 1,2,4-triazolo[1,5-a] pyridines as gastric acid secretion inhibitors |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| KR20070086294A (ko) * | 2004-12-17 | 2007-08-27 | 화이자 인코포레이티드 | 산 펌프 길항물질로 유용한 크로만 유도체 |
| CA2601250C (en) | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| US7666880B2 (en) | 2005-03-21 | 2010-02-23 | S*Bio Pte Ltd. | Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications |
| WO2006101455A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications |
| TW200700064A (en) * | 2005-03-24 | 2007-01-01 | Glaxo Group Ltd | Novel compounds |
| GB0513423D0 (en) * | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| AU2006323025B2 (en) | 2005-12-05 | 2012-07-05 | Pfizer Products Inc. | Polymorphs of a c-Met/HGFR inhibitor |
| PL1959955T3 (pl) | 2005-12-05 | 2011-04-29 | Pfizer Prod Inc | Sposób traktowania nieprawidłowego wzrostu komórek |
| BRPI0708808A2 (pt) * | 2006-03-17 | 2011-06-14 | Raqualia Pharma Inc | Derivados de cromano |
| EP2054036B1 (en) | 2006-07-24 | 2019-12-18 | Singh-Broemer and Company, Inc. | Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening |
| WO2008059373A1 (en) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| EP1974729A1 (en) * | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| GB2471619B (en) * | 2008-03-31 | 2012-10-31 | Council Scient Ind Res | Method for the simultaneous preparation of 3-acetoxy-17-acetamdo-16-formyl-androst-5,16-diene and 3-acetoxy-2'-chloro-5-androsteno[17,6-B]pyridine |
| FI20086158A0 (fi) * | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
| AU2014201644B2 (en) * | 2008-12-03 | 2015-05-21 | Cinclus Pharma Holding AB (publ) | Imidazopyridine derivatives which inhibit the secretion of gastric acid |
| EP2452680B1 (en) * | 2009-07-09 | 2019-12-18 | RaQualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
| MX363456B (es) * | 2013-06-25 | 2019-03-25 | Hoffmann La Roche | Compuestos para tratar atrofia muscular espinal. |
| BR112016013734A2 (pt) | 2013-12-16 | 2017-08-08 | Asana Biosciences Llc | Composto, composição farmacêutica, kit, e uso de um composto |
| ES2692243T3 (es) * | 2014-03-24 | 2018-11-30 | Arqule, Inc. | Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3H-imidazo[4,5-b]piridin-2-il)piridin-2-amina |
| CN106279151A (zh) * | 2015-06-26 | 2017-01-04 | 江苏太瑞生诺生物医药科技有限公司 | 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法 |
| KR101777971B1 (ko) * | 2016-07-05 | 2017-09-12 | 제일약품주식회사 | 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도 |
| KR20190057569A (ko) * | 2017-11-20 | 2019-05-29 | 제일약품주식회사 | 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도 |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE |
| BR112020019277B1 (pt) * | 2018-04-10 | 2024-01-16 | Bayer Aktiengesellschaft | Processo para produção de ácidos 2,6-dialquilfenil acéticos, e seus intermediários |
| RU2732297C2 (ru) * | 2018-11-14 | 2020-09-15 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Производные нестероидных противовоспалительных средств |
| WO2021089580A1 (en) | 2019-11-04 | 2021-05-14 | Cinclus Pharma Ag | Oral formulation of x842 |
| CN118414334A (zh) | 2021-11-05 | 2024-07-30 | 辛克鲁斯制药控股有限公司 （Publ） | 谷氨酸利那拉生甲磺酸盐的多晶型物 |
| KR20240093542A (ko) | 2021-11-05 | 2024-06-24 | 싱클루스 파마 홀딩 에이비 (피유비엘) | 리나프라잔 글루레이트의 염산염의 다형체 |
| KR102496869B1 (ko) * | 2022-07-29 | 2023-02-07 | 제일약품주식회사 | 이미다조[1,2-a]피리딘 화합물의 신규 염, 이의 결정형 및 제조방법 |
| WO2024149833A1 (en) | 2023-01-11 | 2024-07-18 | Cinclus Pharma Holding AB (publ) | Polymorphs of the maleic acid salt of linaprazan glurate |
| WO2024149834A1 (en) | 2023-01-11 | 2024-07-18 | Cinclus Pharma Holding AB (publ) | Polymorphs of the hydrobromide salt of linaprazan glurate |
| WO2024161317A1 (ko) * | 2023-02-01 | 2024-08-08 | 제일약품주식회사 | 약학적 제제, 이의 제조 방법, 및 정제용 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
| DE3269604D1 (en) | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| EP0228006A1 (en) | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
| GB8722488D0 (en) * | 1987-09-24 | 1987-10-28 | Fujisawa Pharmaceutical Co | Imidazopyridine compound |
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1998
- 1998-04-29 SE SE9801526A patent/SE9801526D0/xx unknown
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1999
- 1999-04-16 TW TW088106128A patent/TWI250159B/zh not_active IP Right Cessation
- 1999-04-16 AR ARP990101777A patent/AR015769A1/es active IP Right Grant
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- 1999-04-16 TW TW088106129A patent/TW490466B/zh not_active IP Right Cessation
- 1999-04-23 WO PCT/SE1999/000663 patent/WO1999055706A1/en not_active Application Discontinuation
- 1999-04-23 RU RU2000127020/04A patent/RU2235725C2/ru active
- 1999-04-23 PL PL343801A patent/PL195000B1/pl not_active IP Right Cessation
- 1999-04-23 DE DE69927803T patent/DE69927803T2/de not_active Expired - Lifetime
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- 1999-04-23 ES ES99947038T patent/ES2252975T3/es not_active Expired - Lifetime
- 1999-04-23 US US09/319,890 patent/US6313136B1/en not_active Expired - Fee Related
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- 1999-04-23 KR KR1020007012027A patent/KR100595806B1/ko not_active IP Right Cessation
- 1999-04-23 AU AU43007/99A patent/AU769190B2/en not_active Ceased
- 1999-04-23 TR TR2000/03149T patent/TR200003149T2/xx unknown
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- 1999-04-23 TR TR2001/02728T patent/TR200102728T2/xx unknown
- 1999-04-23 BR BRPI9909996-9A patent/BR9909996B1/pt not_active IP Right Cessation
- 1999-04-23 CA CA002329921A patent/CA2329921A1/en not_active Abandoned
- 1999-04-23 DK DK99947037T patent/DK1073656T3/da active
- 1999-04-23 TR TR2000/03176T patent/TR200003176T2/xx unknown
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- 1999-04-23 UA UA2000106033A patent/UA67769C2/uk unknown
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- 1999-04-23 KR KR1020057022787A patent/KR100595805B1/ko not_active IP Right Cessation
- 1999-04-23 UA UA2000106034A patent/UA66846C2/uk unknown
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- 1999-04-23 EE EEP200000664A patent/EE04916B1/xx not_active IP Right Cessation
- 1999-04-23 SI SI9930850T patent/SI1073656T1/sl unknown
- 1999-04-23 PL PL99343797A patent/PL343797A1/xx unknown
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- 1999-04-23 EP EP99947037A patent/EP1073656B1/en not_active Expired - Lifetime
- 1999-04-23 KR KR1020007012028A patent/KR100650472B1/ko not_active IP Right Cessation
- 1999-04-23 US US09/319,973 patent/US6313137B1/en not_active Expired - Fee Related
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- 1999-04-23 AU AU43006/99A patent/AU769108B2/en not_active Ceased
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- 1999-05-01 SA SA99200064A patent/SA99200064B1/ar unknown
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2000
- 2000-10-18 ZA ZA200005796A patent/ZA200005796B/en unknown
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- 2000-10-23 IL IL139200A patent/IL139200A/en not_active IP Right Cessation
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2001
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- 2001-11-07 HK HK01107808A patent/HK1036981A1/xx not_active IP Right Cessation
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