UA79430C2 - Method for the stepwise attachment of polyethylene glycol to polypeptide - Google Patents
Method for the stepwise attachment of polyethylene glycol to polypeptide Download PDFInfo
- Publication number
- UA79430C2 UA79430C2 UA20031212655A UA20031212655A UA79430C2 UA 79430 C2 UA79430 C2 UA 79430C2 UA 20031212655 A UA20031212655 A UA 20031212655A UA 20031212655 A UA20031212655 A UA 20031212655A UA 79430 C2 UA79430 C2 UA 79430C2
- Authority
- UA
- Ukraine
- Prior art keywords
- peg
- ifn
- polypeptide
- molecular weight
- low molecular
- Prior art date
Links
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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| US7704944B2 (en) | 1997-08-14 | 2010-04-27 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
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| DK1121156T3 (da) * | 1998-10-16 | 2006-06-06 | Biogen Idec Inc | Polymerkonjugater af interferon-beta-1a samt deres anvendelse |
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| CA2369595C (en) * | 1999-04-23 | 2010-10-05 | Alza Corporation | Conjugate having a cleavable linkage for use in a liposome |
| US7303760B2 (en) * | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
| US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
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| US7431921B2 (en) | 2000-04-14 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
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| ATE471956T1 (de) | 2001-01-30 | 2010-07-15 | Kyowa Hakko Kirin Co Ltd | Verzweigte polyalkylenglykole |
| EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
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| BR112021012472A2 (pt) | 2019-01-28 | 2021-11-30 | Toray Industries | Forma modificada por polietileno glicol de um fator de crescimento de hepatócito ou um fragmento ativo do mesmo, e, medicamento |
| BR112021012880A2 (pt) | 2019-01-28 | 2021-11-16 | Toray Industries | Forma modificada por polietileno glicol de um fator de crescimento de hepatócito ou um fragmento ativo do mesmo, e, medicamento |
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| WO1987000056A1 (en) * | 1985-06-26 | 1987-01-15 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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| JP2001508783A (ja) * | 1997-01-29 | 2001-07-03 | ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー | Ｐｅｇ化法 |
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