HUP0300548A3 - Polyol-ifn-betha conjugates - Google Patents
Polyol-ifn-betha conjugatesInfo
- Publication number
- HUP0300548A3 HUP0300548A3 HU0300548A HUP0300548A HUP0300548A3 HU P0300548 A3 HUP0300548 A3 HU P0300548A3 HU 0300548 A HU0300548 A HU 0300548A HU P0300548 A HUP0300548 A HU P0300548A HU P0300548 A3 HUP0300548 A3 HU P0300548A3
- Authority
- HU
- Hungary
- Prior art keywords
- betha
- ifn
- conjugates
- polyol
- betha conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8333998P | 1998-04-28 | 1998-04-28 | |
| PCT/US1999/009161 WO1999055377A2 (en) | 1998-04-28 | 1999-04-28 | Polyol-ifn-beta conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0300548A2 HUP0300548A2 (hu) | 2003-06-28 |
| HUP0300548A3 true HUP0300548A3 (en) | 2005-07-28 |
Family
ID=22177687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300548A HUP0300548A3 (en) | 1998-04-28 | 1999-04-28 | Polyol-ifn-betha conjugates |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6638500B1 (cs) |
| EP (2) | EP1421956B1 (cs) |
| JP (2) | JP4574007B2 (cs) |
| KR (1) | KR100622796B1 (cs) |
| CN (2) | CN1187094C (cs) |
| AR (1) | AR020070A1 (cs) |
| AT (2) | ATE275422T1 (cs) |
| AU (1) | AU762621B2 (cs) |
| BG (2) | BG64694B1 (cs) |
| BR (1) | BR9910023A (cs) |
| CA (2) | CA2330451A1 (cs) |
| CY (1) | CY1108022T1 (cs) |
| CZ (2) | CZ298579B6 (cs) |
| DE (2) | DE69920002T2 (cs) |
| DK (2) | DK1075281T3 (cs) |
| EA (2) | EA005495B1 (cs) |
| EE (1) | EE05214B1 (cs) |
| ES (2) | ES2285286T3 (cs) |
| HU (1) | HUP0300548A3 (cs) |
| IL (1) | IL139286A (cs) |
| NO (2) | NO329749B1 (cs) |
| NZ (1) | NZ507456A (cs) |
| PL (2) | PL196533B1 (cs) |
| PT (2) | PT1421956E (cs) |
| SI (2) | SI1075281T1 (cs) |
| SK (2) | SK286654B6 (cs) |
| TR (2) | TR200003161T2 (cs) |
| TW (2) | TWI232882B (cs) |
| UA (2) | UA79430C2 (cs) |
| WO (1) | WO1999055377A2 (cs) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| US7704944B2 (en) | 1997-08-14 | 2010-04-27 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
| EP1656952B1 (en) * | 1998-10-16 | 2013-12-18 | Biogen Idec MA Inc. | Polyalkylene glycol conjugates of interferon beta-1A and uses thereof |
| NZ510559A (en) | 1998-10-16 | 2003-12-19 | Biogen Inc | Glycosylated interferon-beta fusion proteins that are as active as forms that are not fusion proteins |
| US7303760B2 (en) * | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
| US7238368B2 (en) * | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
| KR100642955B1 (ko) * | 1999-04-23 | 2006-11-10 | 알자 코포레이션 | 방출성 결합 및 그를 함유하는 조성물 |
| US7431921B2 (en) | 1999-08-27 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
| US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| US7144574B2 (en) | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
| TR200101086A3 (cs) * | 1999-10-15 | 2001-08-21 | ||
| EP1270642B1 (en) * | 1999-12-24 | 2011-08-31 | Kyowa Hakko Kirin Co., Ltd. | Branched polyalkylene glycols |
| DK1250154T3 (da) | 2000-01-10 | 2009-08-17 | Maxygen Holdings Ltd | G-CSF-konjugater |
| ATE428445T1 (de) | 2000-02-11 | 2009-05-15 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
| ATE471956T1 (de) | 2001-01-30 | 2010-07-15 | Kyowa Hakko Kirin Co Ltd | Verzweigte polyalkylenglykole |
| EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
| JP2004534523A (ja) | 2001-02-27 | 2004-11-18 | マキシゲン・エイピーエス | 新規なインターフェロンβ様分子 |
| IL159524A0 (en) | 2001-07-11 | 2004-06-01 | Maxygen Holdings Ltd | G-csf conjugates |
| CN101700401B (zh) | 2002-01-18 | 2013-08-14 | 比奥根艾迪克Ma公司 | 具有用于共轭生物活性化合物的部分的聚亚烷基二醇 |
| TWI334785B (en) | 2002-06-03 | 2010-12-21 | Serono Lab | Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race |
| WO2004020468A2 (en) * | 2002-08-28 | 2004-03-11 | Maxygen Aps | Interferon beta-like molecules for treatment of cancer |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| WO2004060299A2 (en) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of interferon-beta with enhanced biological potency |
| CA2511815A1 (en) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| ATE431403T1 (de) | 2003-03-20 | 2009-05-15 | Bayer Healthcare Llc | Fvii oder fviia varianten |
| TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| EP2641611A3 (en) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Combination therapy |
| AU2008201682B2 (en) * | 2004-02-02 | 2011-02-24 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
| AU2005209926B2 (en) * | 2004-02-02 | 2007-09-06 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
| EP1586334A1 (en) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugates with peg |
| AU2005244448B2 (en) | 2004-05-17 | 2011-03-17 | Ares Trading S.A. | Hydrogel interferon formulations |
| WO2005117949A1 (en) | 2004-06-01 | 2005-12-15 | Ares Trading S.A. | Stabilized interferon liquid formulations |
| EA012281B1 (ru) | 2004-06-01 | 2009-08-28 | Арес Трейдинг С.А. | Способ стабилизации белков |
| TW200633718A (en) * | 2004-12-16 | 2006-10-01 | Applied Research Systems | Treatment of hepatitis c in the asian population |
| JP5243041B2 (ja) | 2004-12-21 | 2013-07-24 | ネクター セラピューティックス | 安定化ポリマーチオール試薬 |
| NZ584597A (en) | 2004-12-22 | 2011-09-30 | Ambrx Inc | Modified human growth hormone |
| MX2007007587A (es) | 2004-12-22 | 2007-12-11 | Ambrx Inc | Formulaciones de la hormona del crecimiento humano que comprenden un aminoacido codificado de manera no natural. |
| US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
| EP2360170A3 (en) | 2005-06-17 | 2012-03-28 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered proteins comprinsing at least one non-native cysteine |
| CN101257926A (zh) * | 2005-08-04 | 2008-09-03 | 尼克塔治疗亚拉巴马公司 | G-csf部分与聚合物的轭合物 |
| US20080219952A1 (en) | 2005-08-26 | 2008-09-11 | Ares Trading S.A. | Process For the Preparation of Glycosylated Interferon Beta |
| EA013816B1 (ru) | 2005-09-01 | 2010-08-30 | Арес Трейдинг С.А. | Лечение неврита зрительного нерва |
| US20070238656A1 (en) * | 2006-04-10 | 2007-10-11 | Eastman Kodak Company | Functionalized poly(ethylene glycol) |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| AU2007248680C1 (en) * | 2006-05-02 | 2014-01-23 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| RU2008145084A (ru) | 2006-05-24 | 2010-06-27 | Ново Нордиск Хелс Кеа Аг (Ch) | Аналоги фактора ix, имеющие пролонгированное время полужизни in vivo |
| PL2026832T3 (pl) | 2006-05-24 | 2012-08-31 | Merck Serono Sa | Skojarzony reżim interferonu beta i kladrybiny do leczenia stwardnienia rozsianego |
| CN101675071B (zh) * | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| WO2009080699A2 (en) | 2007-12-20 | 2009-07-02 | Merck Serono S.A. | Peg-interferon-beta formulations |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| CN101525381B (zh) * | 2008-03-04 | 2012-04-18 | 北京百川飞虹生物科技有限公司 | 一种重组复合干扰素及其表达载体的构建和表达 |
| US20100112660A1 (en) * | 2008-05-30 | 2010-05-06 | Barofold, Inc. | Method for Derivatization of Proteins Using Hydrostatic Pressure |
| US20110124614A1 (en) * | 2008-10-25 | 2011-05-26 | Halina Offner | Methods And Compositions For The Treatment of Autoimmune Disorders |
| DE102009032179A1 (de) * | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
| ES2365343B1 (es) | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| CN105524164A (zh) | 2010-02-16 | 2016-04-27 | 诺沃—诺迪斯克有限公司 | 具有降低的vwf结合的因子viii分子 |
| AR080993A1 (es) | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
| WO2011123813A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| EP2569331A1 (en) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptide inhibitors of vla4 |
| US20130183280A1 (en) | 2010-07-15 | 2013-07-18 | Novo Nordisk A/S | Stabilized factor viii variants |
| JP6042335B2 (ja) | 2010-09-15 | 2016-12-14 | ノヴォ ノルディスク アー/エス | 細胞取込みが低下した第viii因子変異体 |
| KR101451357B1 (ko) * | 2011-02-18 | 2014-10-15 | 주식회사 스템디알 | Sirt1 발현 유도 물질을 포함하는 패혈증 또는 패혈증 쇼크의 예방 또는 치료용 조성물 |
| BR112014000055A2 (pt) | 2011-07-01 | 2017-06-13 | Bayer Ip Gmbh | polipeptídeos de fusão de relaxina e usos dos mesmos |
| CN109134642A (zh) * | 2011-10-01 | 2019-01-04 | 株式会社糖锁工学研究所 | 加成糖链的多肽及含有该多肽的医药组合物 |
| MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
| KR20140130705A (ko) | 2012-02-29 | 2014-11-11 | 도레이 카부시키가이샤 | 체강액 저류 억제제 |
| AU2014245917B2 (en) | 2013-03-29 | 2017-09-28 | Glytech, Inc. | Polypeptide having sialylated sugar chains attached thereto |
| US11759500B2 (en) | 2014-07-24 | 2023-09-19 | Abion Inc. | PEGylated interferon-beta variant |
| WO2016013697A1 (ko) * | 2014-07-24 | 2016-01-28 | 에이비온 주식회사 | 인터페론-베타 변이체의 폴리에틸렌글리콜 배합체 |
| SMT202100016T1 (it) | 2014-08-19 | 2021-03-15 | Biogen Ma Inc | Metodo di pegilazione |
| ES2903448T3 (es) | 2015-05-01 | 2022-04-01 | Allysta Pharmaceuticals Inc | Peptidomiméticos de adiponectina para el tratamiento de trastornos oculares |
| SI3310816T1 (sl) * | 2015-06-19 | 2020-12-31 | Eisai R&D Management Co.,Ltd. | CYS80-konjugirani imunoglobulini |
| SG10201912972SA (en) | 2015-11-09 | 2020-03-30 | Univ Colorado Regents | Compositions and methods for treatment of homocystinuria |
| CA3059592A1 (en) * | 2017-04-17 | 2018-10-25 | The Regents Of The University Of Colorado, A Body Corporate | Optimization of enzyme replacement therapy for treatment of homocystinuria |
| CN119097635A (zh) | 2017-11-24 | 2024-12-10 | 默克专利股份公司 | 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法 |
| BR112021012472A2 (pt) | 2019-01-28 | 2021-11-30 | Toray Industries | Forma modificada por polietileno glicol de um fator de crescimento de hepatócito ou um fragmento ativo do mesmo, e, medicamento |
| CA3125320A1 (en) | 2019-01-28 | 2020-08-06 | Toray Industries, Inc. | Polyethylene glycol-modified form of hepatocyte growth factor or active fragment thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| DE3676670D1 (de) * | 1985-06-26 | 1991-02-07 | Cetus Corp | Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung. |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5208344A (en) * | 1987-07-31 | 1993-05-04 | American Home Products Corporation | Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| HUT75533A (en) | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| JP2996415B2 (ja) | 1994-03-31 | 1999-12-27 | アムジエン・インコーポレーテツド | 巨核球の成長と分化を刺激するモノpeg化mgdfポリペプチド |
| CA2190502A1 (en) * | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| US5851984A (en) * | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| KR0176625B1 (ko) | 1996-11-05 | 1999-04-01 | 삼성전자주식회사 | 적외선 물체검출장치 |
| ATE200030T1 (de) * | 1997-01-29 | 2001-04-15 | Polymasc Pharmaceuticals Plc | Pegylationsverfahren |
| CA2296770A1 (en) * | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US6531122B1 (en) * | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
-
1999
- 1999-04-28 DK DK99920094T patent/DK1075281T3/da active
- 1999-04-28 DK DK04003053T patent/DK1421956T3/da active
- 1999-04-28 UA UA20031212655A patent/UA79430C2/uk unknown
- 1999-04-28 HU HU0300548A patent/HUP0300548A3/hu unknown
- 1999-04-28 CA CA002330451A patent/CA2330451A1/en not_active Abandoned
- 1999-04-28 CZ CZ20003995A patent/CZ298579B6/cs not_active IP Right Cessation
- 1999-04-28 WO PCT/US1999/009161 patent/WO1999055377A2/en not_active Ceased
- 1999-04-28 NZ NZ507456A patent/NZ507456A/en not_active IP Right Cessation
- 1999-04-28 SI SI9930662T patent/SI1075281T1/xx unknown
- 1999-04-28 ES ES04003053T patent/ES2285286T3/es not_active Expired - Lifetime
- 1999-04-28 CA CA002565375A patent/CA2565375A1/en not_active Abandoned
- 1999-04-28 PL PL378728A patent/PL196533B1/pl not_active IP Right Cessation
- 1999-04-28 DE DE69920002T patent/DE69920002T2/de not_active Expired - Lifetime
- 1999-04-28 SI SI9930974T patent/SI1421956T1/sl unknown
- 1999-04-28 PL PL344490A patent/PL193352B1/pl not_active IP Right Cessation
- 1999-04-28 EA EA200300382A patent/EA005495B1/ru not_active IP Right Cessation
- 1999-04-28 BR BR9910023-1A patent/BR9910023A/pt active Search and Examination
- 1999-04-28 EP EP04003053A patent/EP1421956B1/en not_active Expired - Lifetime
- 1999-04-28 UA UA2000116719A patent/UA66857C2/uk unknown
- 1999-04-28 CN CNB998054968A patent/CN1187094C/zh not_active Expired - Fee Related
- 1999-04-28 SK SK66-2007A patent/SK286654B6/sk not_active IP Right Cessation
- 1999-04-28 EE EEP200000614A patent/EE05214B1/xx not_active IP Right Cessation
- 1999-04-28 PT PT04003053T patent/PT1421956E/pt unknown
- 1999-04-28 TR TR2000/03161T patent/TR200003161T2/xx unknown
- 1999-04-28 TR TR2001/01751T patent/TR200101751T2/xx unknown
- 1999-04-28 CZ CZ20050048A patent/CZ298597B6/cs not_active IP Right Cessation
- 1999-04-28 DE DE69936409T patent/DE69936409T2/de not_active Expired - Lifetime
- 1999-04-28 AT AT99920094T patent/ATE275422T1/de active
- 1999-04-28 EP EP99920094A patent/EP1075281B1/en not_active Expired - Lifetime
- 1999-04-28 PT PT99920094T patent/PT1075281E/pt unknown
- 1999-04-28 KR KR1020007011587A patent/KR100622796B1/ko not_active Expired - Fee Related
- 1999-04-28 IL IL13928699A patent/IL139286A/xx not_active IP Right Cessation
- 1999-04-28 CN CNB2004100898478A patent/CN100335503C/zh not_active Expired - Fee Related
- 1999-04-28 JP JP2000545574A patent/JP4574007B2/ja not_active Expired - Lifetime
- 1999-04-28 AT AT04003053T patent/ATE365563T1/de active
- 1999-04-28 EA EA200001111A patent/EA003789B1/ru not_active IP Right Cessation
- 1999-04-28 ES ES99920094T patent/ES2224649T3/es not_active Expired - Lifetime
- 1999-04-28 AU AU37674/99A patent/AU762621B2/en not_active Ceased
- 1999-04-28 SK SK1622-2000A patent/SK286217B6/sk not_active IP Right Cessation
- 1999-04-29 AR ARP990101987A patent/AR020070A1/es active IP Right Grant
- 1999-07-26 TW TW088112596A patent/TWI232882B/zh active
- 1999-07-26 TW TW093123043A patent/TWI266800B/zh active
-
2000
- 2000-10-17 BG BG104871A patent/BG64694B1/bg unknown
- 2000-10-17 BG BG109291A patent/BG65046B1/bg unknown
- 2000-10-23 NO NO20005337A patent/NO329749B1/no not_active IP Right Cessation
- 2000-10-30 US US09/698,133 patent/US6638500B1/en not_active Expired - Lifetime
-
2003
- 2003-08-28 US US10/649,609 patent/US7357925B2/en not_active Expired - Fee Related
-
2007
- 2007-02-13 US US11/674,476 patent/US7700314B2/en not_active Expired - Fee Related
- 2007-07-19 CY CY20071100966T patent/CY1108022T1/el unknown
-
2010
- 2010-03-09 NO NO20100324A patent/NO332224B1/no not_active IP Right Cessation
- 2010-04-26 JP JP2010100840A patent/JP2010184929A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0300548A3 (en) | Polyol-ifn-betha conjugates | |
| DE69924108D1 (en) | Offshore-bohrsystem | |
| GB2339200B (en) | Genostics | |
| DE69918845D1 (en) | Polyketonlösung | |
| GB9713980D0 (en) | New conjugates | |
| GB2337049B (en) | Trisresorcinyltriazines | |
| PL347427A1 (en) | Thiazole-derivatives | |
| GB2336996B (en) | Multi-desk | |
| GB9809421D0 (en) | Aroma-vac | |
| DE59905941D1 (en) | Methoximinophenylessigsäureamide | |
| GB9815709D0 (en) | Ospro-ski | |
| GB9803582D0 (en) | Post-protectors | |
| GB9827813D0 (en) | Pharmaceutical conjugates | |
| GB9817832D0 (en) | Curvers | |
| GB9818451D0 (en) | Conjugates | |
| GB2337526B (en) | Easy rockeries | |
| GB9825105D0 (en) | Pharamaceutical conjugates | |
| GB9912039D0 (en) | Gene-activating conjugates | |
| HK1033279A (en) | Hemoglobin-polysaccharide conjugates | |
| GB9801608D0 (en) | Camrar II | |
| PL108545U1 (en) | Cprner piece | |
| AU135781S (en) | Rook - chess piece | |
| GB9803578D0 (en) | Vac-Mag | |
| GB9815448D0 (en) | Tranelock | |
| GB9805071D0 (en) | Vangs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |