UA77146C2 - Newcastle disease virus infectious clones, vaccines and diagnostic set - Google Patents
Newcastle disease virus infectious clones, vaccines and diagnostic set Download PDFInfo
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- UA77146C2 UA77146C2 UA2001010408A UA2001010408A UA77146C2 UA 77146 C2 UA77146 C2 UA 77146C2 UA 2001010408 A UA2001010408 A UA 2001010408A UA 2001010408 A UA2001010408 A UA 2001010408A UA 77146 C2 UA77146 C2 UA 77146C2
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| EP98202054A EP0974660A1 (de) | 1998-06-19 | 1998-06-19 | Newcastle-Krankheitsvirus Infektiöser Klone, Impfstoffe und Diagnosetest |
| PCT/NL1999/000377 WO1999066045A1 (en) | 1998-06-19 | 1999-06-17 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
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| UA77146C2 true UA77146C2 (en) | 2006-11-15 |
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| UA2001010408A UA77146C2 (en) | 1998-06-19 | 1999-06-17 | Newcastle disease virus infectious clones, vaccines and diagnostic set |
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| EP (2) | EP0974660A1 (de) |
| JP (3) | JP2002518012A (de) |
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| CN (2) | CN101275142A (de) |
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| AT (1) | ATE367442T1 (de) |
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| ID (1) | ID27343A (de) |
| IL (2) | IL140381A0 (de) |
| NO (1) | NO329193B1 (de) |
| NZ (1) | NZ508982A (de) |
| PL (1) | PL197722B1 (de) |
| PT (1) | PT1088077E (de) |
| SI (1) | SI1088077T1 (de) |
| TR (1) | TR200100350T2 (de) |
| UA (1) | UA77146C2 (de) |
| WO (1) | WO1999066045A1 (de) |
| ZA (1) | ZA200100241B (de) |
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| EP0974660A1 (de) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle-Krankheitsvirus Infektiöser Klone, Impfstoffe und Diagnosetest |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| AU4971500A (en) * | 1999-05-05 | 2000-11-21 | University Of Maryland | Production of novel newcastle disease virus strains from cdnas and improved liveattenuated newcastle disease vaccines |
| US10383936B2 (en) * | 1999-05-05 | 2019-08-20 | University Of Maryland, College Park | Infectious laryngotracheitis virus (ILTV) vaccine using recombinant newcastle disease virus vector |
| CA2312626A1 (en) * | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
| EP1074614B1 (de) * | 1999-07-27 | 2004-07-07 | Akzo Nobel N.V. | Rekombinantes Newcastle-Krankheitsvirus zur in ovo Impfung |
| DK1297110T3 (da) | 2000-06-23 | 2009-11-16 | Intervet Int Bv | Attenueret bovin respiratorisk syncytialvirus |
| DK1383795T3 (da) * | 2000-11-02 | 2007-05-29 | Intervet Int Bv | Rekombinant nucleoproteinmutant fra Newcastle disease-virus som markörvaccine |
| KR100437888B1 (ko) * | 2001-07-30 | 2004-07-03 | 주식회사 인트론바이오테크놀로지 | 뉴캐슬병 바이러스 검출용 프라이머 및 상기 프라이머를이용한 뉴캐슬병 바이러스 검출, 병원성 및 유전형 조사방법 |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| ATE307606T1 (de) * | 2001-10-04 | 2005-11-15 | Ct Voor Onderzoek In Diergenee | Abgeschwächter mutantenstamm eines virus der newcastle-krankheit für eine in ovo impfung und dessen benutzung |
| WO2003072725A2 (en) * | 2002-02-21 | 2003-09-04 | Mount Sinai School Of Medicine | Recombinant negative strand virus rna expression systems and vaccines |
| TW200502402A (en) * | 2002-12-06 | 2005-01-16 | Wyeth Corp | Escape mutants of newcastle disease virus as marker vaccines |
| JP2007526215A (ja) * | 2003-05-05 | 2007-09-13 | ダウ アグロサイエンス リミテッド ライアビリティー カンパニー | トランスジェニック植物細胞に由来する安定な免疫予防的および治療的組成物ならびにその産生方法 |
| AU2004235813B2 (en) * | 2003-05-05 | 2010-07-29 | Boyce Thompson Institute For Plant Research | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| US7270990B2 (en) | 2003-06-20 | 2007-09-18 | Microbix Biosystems, Inc. | Virus production |
| US7527638B2 (en) | 2003-12-16 | 2009-05-05 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
| MY146476A (en) | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
| GB0423681D0 (en) * | 2004-10-26 | 2004-11-24 | Sec Dep For Environment Food & | Vaccine and nucleic acids |
| KR20070085314A (ko) | 2004-11-12 | 2007-08-27 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 재조합 뉴캐슬 질환 바이러스 |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| PT2529747T (pt) * | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
| EP1996610A1 (de) * | 2006-03-15 | 2008-12-03 | Intervet International BV | Rekombinantes newcastle-krankheit-virus, das h5-hemagglutinin des vogelgrippenvirus exprimiert |
| MX2008011727A (es) * | 2006-03-15 | 2008-12-10 | Intervet Int Bv | Vectores de virus mononegaviral recombinantes. |
| KR100776398B1 (ko) * | 2006-03-23 | 2007-11-28 | 주식회사 고려비엔피 | 조류 ｈｎ 단백질의 에피토프 및 상기 변이 에피토프를포함하는 뉴캐슬병 바이러스 |
| KR100801180B1 (ko) | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
| KR100874256B1 (ko) | 2007-02-12 | 2008-12-16 | 대한민국 | 대장균 내독소 단백질 및 뉴캐슬병 바이러스뉴라미니데이즈 에피토프의 융합단백질 및 이의 용도 |
| KR100955502B1 (ko) * | 2007-11-30 | 2010-04-30 | 대한민국 | 병원성 뉴캐슬병 바이러스 항체와 특이적으로 반응하는펩타이드 및 그의 용도 |
| EP2085092A1 (de) | 2008-01-29 | 2009-08-05 | Bayer Schering Pharma Aktiengesellschaft | Abgeschwächte onkolytische Paramyxoviren zur Kodierung von Vogel-Zytokinen |
| US7794714B2 (en) * | 2008-03-14 | 2010-09-14 | The United States Of America As Represented By The Secretary Of Agriculture | Newcastle disease virus monoclonal antibodies |
| US20090258035A1 (en) * | 2008-03-21 | 2009-10-15 | The United States Of America, As Represented By The Secretary Of Agriculture | Avian virus vaccines and uses thereof |
| JP2012509308A (ja) * | 2008-11-19 | 2012-04-19 | ラボラトリオ アヴィメキシコ エスエー ディーイー シーヴィー | 遺伝子組み換え不活性化ウィルスベクターワクチン |
| EP2987856B1 (de) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimäre newcastle-krankheitsviren und verwendungen davon |
| CA2771540C (en) * | 2009-08-21 | 2019-01-15 | Merial Limited | Recombinant avian paramyxovirus vaccine and method for making and using thereof |
| US20110110975A1 (en) * | 2009-11-06 | 2011-05-12 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| ES2380289T3 (es) | 2009-11-30 | 2012-05-10 | United Cancer Research Institute | Nuevo clon del virus de la enfermedad de Newcastle, su fabricación y aplicación en el tratamiento médico del cáncer |
| WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| US9265813B2 (en) | 2011-10-27 | 2016-02-23 | Wellstat Ophthalmics Corporation | Vectors encoding rod-derived cone viability factor |
| SI2785373T1 (sl) | 2011-11-30 | 2020-02-28 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinantni vektorji HVT, ki izražajo antigene aviarnih patogenov in uporabe le-teh |
| KR101374192B1 (ko) * | 2011-12-21 | 2014-03-14 | 대한민국 | 제4형 조류파라믹소바이러스 ｈｎ 단백질 및 이를 포함하는 ｈｉ법 검사용 항원진단액 |
| GEP20196976B (en) | 2013-03-14 | 2019-06-10 | Sloan Kettering Cancer Center Memorial | Newcastle disease viruses and uses thereof |
| CN104059942B (zh) * | 2013-03-20 | 2016-12-28 | 湖北省农业科学院畜牧兽医研究所 | 新城疫病毒耐热活疫苗载体系统及其应用 |
| US20140341950A1 (en) * | 2013-05-15 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Recombinant avian paramyxovirus vaccine and method for making and using thereof |
| EP3441084A1 (de) | 2014-02-27 | 2019-02-13 | Viralytics Limited | Onkolytisches virus und immunstimulator zur kombinationsbehandlung von krebs |
| US10780158B2 (en) | 2015-11-16 | 2020-09-22 | Georgia State University Research Foundation, Inc. | Tunable vaccine platform against pathogens of the paramyxovirus family |
| US10063211B2 (en) * | 2016-02-03 | 2018-08-28 | Qualcomm Incorporated | Compact bypass and decoupling structure for millimeter-wave circuits |
| RU2022108149A (ru) | 2016-02-03 | 2022-05-05 | СиДжи ДИСКАВЕРИ, ИНК. | Композиции гемагглютинина гриппа с гетерологичными эпитопами и/или измененными сайтами расщепления при созревании |
| US10196616B2 (en) | 2017-02-15 | 2019-02-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Altered avian virus for in-ovo inoculation and methods of use thereof |
| CA3088906A1 (en) * | 2018-02-28 | 2019-09-06 | Regeneron Pharmaceuticals, Inc. | Systems and methods for identifying viral contaminants |
| US20200297787A1 (en) * | 2018-07-13 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| CN109735552A (zh) * | 2019-02-27 | 2019-05-10 | 苏州世诺生物技术有限公司 | 禽新城疫病毒新型基因工程亚单位疫苗 |
| CN110018304A (zh) * | 2019-05-15 | 2019-07-16 | 河南省农业科学院 | 一种新城疫抗体阻断检测试纸 |
| CN110240635B (zh) * | 2019-06-10 | 2022-04-22 | 华中农业大学 | 检测新城疫病毒抗体的多肽及其elisa检测试剂盒 |
| CN110257562A (zh) * | 2019-07-31 | 2019-09-20 | 河北农业大学 | 一种raa-lfd检测鸡传染性喉气管炎病毒的引物和探针组合及其应用 |
| KR102154796B1 (ko) * | 2019-10-18 | 2020-09-22 | 주식회사 바이오포아 | 변이 뉴캣슬병 바이러스 및 상기 바이러스를 이용한 조류 백신 |
| CN110938711A (zh) * | 2019-12-20 | 2020-03-31 | 河北农业大学 | 一种检测鸡传染性喉气管炎病毒的实时荧光raa引物和探针、试剂盒及其使用方法 |
| CN111334528B (zh) * | 2020-03-20 | 2022-02-18 | 山东农业大学 | 水貂肠炎细小病毒全基因组感染性克隆及其构建方法和应用 |
| CN112048484A (zh) * | 2020-07-27 | 2020-12-08 | 华南农业大学 | 一株表达传染性法氏囊强毒株vp2蛋白的基因ⅶ型新城疫重组病毒和疫苗 |
| CN114214338B (zh) * | 2021-08-26 | 2023-02-03 | 扬州大学 | 猪源piv5全长感染性克隆及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| EP1394259A3 (de) | 1994-07-18 | 2004-04-14 | Karl-Klaus Prof. Dr. Conzelmann | Rekombinantes infektiöses nicht-in-Segmente-geteiltes negativ-Strange-RNS-Virus |
| AU729518B2 (en) * | 1995-06-07 | 2001-02-01 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| DE69510207T3 (de) * | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
| EP0839912A1 (de) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren |
| EP0974660A1 (de) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle-Krankheitsvirus Infektiöser Klone, Impfstoffe und Diagnosetest |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
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