UA41948C2 - Заміщені гідроксилом азетидинони, придатні як гіпохолестеринемічний засіб, фармацевтична композиція на їх основі та спосіб лікування або профілактики - Google Patents

Заміщені гідроксилом азетидинони, придатні як гіпохолестеринемічний засіб, фармацевтична композиція на їх основі та спосіб лікування або профілактики

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Publication number
UA41948C2
UA41948C2 UA96031081A UA96031081A UA41948C2 UA 41948 C2 UA41948 C2 UA 41948C2 UA 96031081 A UA96031081 A UA 96031081A UA 96031081 A UA96031081 A UA 96031081A UA 41948 C2 UA41948 C2 UA 41948C2
Authority
UA
Ukraine
Prior art keywords
substituted
hypocholesterinemic
aryl
azetidinons
hydroxyl
Prior art date
Application number
UA96031081A
Other languages
English (en)
Russian (ru)
Inventor
Стюарт Б Розенблум
Сандіп Дугар
Сандип ДУГАР
Дуане А. Бьорнетт
Дуане А. Бернетт
Джон В. Кладер
Брайєн А. Мекіттрік
Брайен А. Мекиттрик
Original Assignee
Шерінг Корпорейшн
Шеринг Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799377&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA41948(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Шерінг Корпорейшн, Шеринг Корпорейшн filed Critical Шерінг Корпорейшн
Publication of UA41948C2 publication Critical patent/UA41948C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід належить до заміщених гідроксилом азетидинонам, придатним як гіпохолестеринемічний засіб в галузі лікування і профілактики атеросклерозу. Нові гіпохолестеринемичні сполуки даного винаходу мають формулу (I) (I) або є фармацевтично прийнятною сіллю сполуки формули (I) де Аr1 і Аr2 незалежно один від одного вибрані з групи, що включає арил і заміщений залишком R4 арил Аr3, - арил або заміщений залишком R5 арил, X, Y і Z незалежно один від одного вибрані з групи, що включає -СН2-, -СН(нижчий алкіл) -, -С(ді-нижчий алкіл)-,R і R2 незалежно один від одного вибрані з групи, що включає --OR6, -O(CO)R6, -O(CO)OR9 і -O(CO)NR6R7,R1 і R3 незалежно один від одного вибрані з групи, що включає водень, нижчий алкіл і арил, q, - 0 або 1,r - 0 або 1, m,n і p незалежно один від одного означають число 0 ¸ 4, при цьому щонайменше один з індексів q і r означає число 1, і сума індексів m, n, p, q і r дорівнює 1, 2,3,4,5 або 6, і якщо p - 0, і r - 1, то сума m, q і n дорівнює 1,2,3,4 або 5
UA96031081A 1993-09-21 1994-09-14 Заміщені гідроксилом азетидинони, придатні як гіпохолестеринемічний засіб, фармацевтична композиція на їх основі та спосіб лікування або профілактики UA41948C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10244093A 1993-09-21 1993-09-21
US08/257,593 US5631365A (en) 1993-09-21 1994-06-09 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
PCT/US1994/010099 WO1995008532A1 (en) 1993-09-21 1994-09-14 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
UA41948C2 true UA41948C2 (uk) 2001-10-15

Family

ID=26799377

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96031081A UA41948C2 (uk) 1993-09-21 1994-09-14 Заміщені гідроксилом азетидинони, придатні як гіпохолестеринемічний засіб, фармацевтична композиція на їх основі та спосіб лікування або профілактики

Country Status (35)

Country Link
US (5) US5631365A (uk)
EP (1) EP0720599B1 (uk)
JP (1) JP2803908B2 (uk)
KR (1) KR100186853B1 (uk)
CN (1) CN1050830C (uk)
AT (1) ATE180249T1 (uk)
AU (1) AU681445C (uk)
BE (1) BE2014C056I2 (uk)
BR (1) BR1100159A (uk)
CA (1) CA2172149C (uk)
CZ (2) CZ288861B6 (uk)
DE (3) DE69418613T2 (uk)
DK (1) DK0720599T3 (uk)
ES (1) ES2132432T3 (uk)
FI (1) FI110321B (uk)
FR (1) FR05C0040I2 (uk)
GE (1) GEP20043149B (uk)
GR (1) GR3030312T3 (uk)
HU (1) HU221185B1 (uk)
IL (1) IL110956A (uk)
LU (4) LU91050I2 (uk)
MA (1) MA23332A1 (uk)
MY (1) MY111314A (uk)
NL (2) NL300132I2 (uk)
NO (6) NO305902B1 (uk)
NZ (1) NZ274041A (uk)
PL (1) PL182617B1 (uk)
RU (1) RU2138480C1 (uk)
SG (1) SG46208A1 (uk)
SK (1) SK281067B6 (uk)
TN (1) TNSN94094A1 (uk)
TW (1) TW427974B (uk)
UA (1) UA41948C2 (uk)
WO (1) WO1995008532A1 (uk)
ZA (1) ZA947086B (uk)

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