AR035739A1 - Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares - Google Patents

Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares

Info

Publication number
AR035739A1
AR035739A1 ARP020100267A ARP020100267A AR035739A1 AR 035739 A1 AR035739 A1 AR 035739A1 AR P020100267 A ARP020100267 A AR P020100267A AR P020100267 A ARP020100267 A AR P020100267A AR 035739 A1 AR035739 A1 AR 035739A1
Authority
AR
Argentina
Prior art keywords
aryl
group
lower alkyl
coor6
independently
Prior art date
Application number
ARP020100267A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR035739A1 publication Critical patent/AR035739A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Una composición, que comprende: (a) por lo menos un secuestrante de los ácidos biliares; y (b) por lo menos un inhibidor de la absorción de los esteroles, representado por la fórmula (1) o los isómeros del mismo, o las sales o solvatos farmacéuticamente aceptables de los compuestos de la fórmula (1) o de los isómeros de los mismos, o las prodrogas de los compuestos de la fórmula (1) o de los isómeros, sales o solvatos, de los mismos y en la fórmula (1) anteriormente mencionada: Ar1 y Ar2 son independientemente entre sí, seleccionados de entre el grupo consistente en arilo y arilo R4-sustituido; Ar3 es arilo o arilo R5-sustituido; X, Y y Z, son independientemente entre sí seleccionados de entre el grupo consistente en -CH2-, -CH(alquilo inferior)- y -C(alquilo diinferior)-; R y R2 son independientemente entre sí, seleccionados de entre el grupo consistente en -OR6, -O(CO)R6, -O(CO)OR9 y -O(CO)NR6R7; R1 y R3 son independientemente entre sí seleccionados de entre el grupo consistente en hidrógeno, alquilo inferior y arilo; q vale 0 o 1; r vale 0 o 1; m, n, y p, independientemente entre sí, son seleccionados de entre el grupo consistente en 0, 1, 2, 3 o 4 con la condición que por lo menos uno de q y r, valga 1; y la suma de m, n , p, q y r valga 1, 2, 3, 4, 5 o 6 y con la condición que cuando p es 0 y r es 1, la suma de m, q y n es 1, 2, 3, 4 o 5; R4 representa de 1 a 5 sustituyentes independientemente entre sí seleccionados de entre el grupo consistente en alquilo inferior, -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10-COOR6, -O(CH2)1-10CONR6R7, -(alquileno inferior)COOR6, CH=CH-COOR6, -CF3, -CN, NO2 y halógeno; R5 es de 1 a 5 sustituyentes independientemente entre si seleccionados de entre el grupo consistente en -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, NR6(CO)NR7R8, NR6SO2R9, -COOR6, -CONR6R7-, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10COOR6, -O(CH2)1-10-CONR6R7, -(alquileno inferior) COOR6 y -CH=CH-COOR6; R6, R7 y R8 independientemente entre sí, son seleccionados de entre el grupo consistente en hidrógeno, alquilo inferior, arilo y alquilo inferior arilo-sustituido; y R9 es alquilo inferior, arilo o alquilo inferior, arilo-sustituido; también combinaciones terapéuticas y métodos, que incluyen: a) por lo menos un secuestrante de los ácidos biliares; y: (b) por lo menos una azatidinona sustituida o un b lactamo sustituido, que son inhibidores de la absorción de los esteroles, útiles en el tratamiento de las condiciones vasculares, diabetes, obesidad y para disminuir los niveles de los esteroles en el plasma; así como el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento y prevención de dichas enfermedades.
ARP020100267A 2001-01-26 2002-01-25 Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares AR035739A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26460001P 2001-01-26 2001-01-26
US32384201P 2001-09-21 2001-09-21

Publications (1)

Publication Number Publication Date
AR035739A1 true AR035739A1 (es) 2004-07-07

Family

ID=26950649

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100267A AR035739A1 (es) 2001-01-26 2002-01-25 Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares

Country Status (16)

Country Link
US (2) US20030053981A1 (es)
EP (2) EP1785144A3 (es)
JP (1) JP2004521894A (es)
AR (1) AR035739A1 (es)
AT (1) ATE369851T1 (es)
AU (1) AU2002241956A1 (es)
CA (1) CA2434033A1 (es)
CY (1) CY1106915T1 (es)
DE (1) DE60221798T2 (es)
DK (1) DK1363668T3 (es)
ES (1) ES2287250T3 (es)
MX (1) MXPA03006631A (es)
PT (1) PT1363668E (es)
SI (1) SI1363668T1 (es)
TW (1) TW200744638A (es)
WO (1) WO2002058733A2 (es)

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WO2002058733A3 (en) 2003-06-26
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CY1106915T1 (el) 2012-09-26
EP1363668A2 (en) 2003-11-26
TW200744638A (en) 2007-12-16
JP2004521894A (ja) 2004-07-22
EP1363668B1 (en) 2007-08-15
PT1363668E (pt) 2007-11-07
EP1785144A2 (en) 2007-05-16
WO2002058733B1 (en) 2003-08-14
US20080261942A1 (en) 2008-10-23
SI1363668T1 (sl) 2007-12-31
CA2434033A1 (en) 2002-08-01
DK1363668T3 (da) 2007-11-05
MXPA03006631A (es) 2004-03-18
US20030053981A1 (en) 2003-03-20
ES2287250T3 (es) 2007-12-16
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WO2002058733A9 (en) 2003-03-06

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