ECSP034547A - Derivados de pirazol para el tratamiento de enfermedades virales - Google Patents
Derivados de pirazol para el tratamiento de enfermedades viralesInfo
- Publication number
- ECSP034547A ECSP034547A EC2003004547A ECSP034547A ECSP034547A EC SP034547 A ECSP034547 A EC SP034547A EC 2003004547 A EC2003004547 A EC 2003004547A EC SP034547 A ECSP034547 A EC SP034547A EC SP034547 A ECSP034547 A EC SP034547A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- heterocyclyl
- compounds
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a nuevos y conocidos derivados de pirazol, un proceso para su elaboración, las composiciones farmacéuticas y el uso de tales compuestos en medicina, en particular, los compuestos de fórmula I son inhibidores de la enzima transcriptasa reversa del virus de inmunodeficiencia humana que esta implicada en la replicación viral. Por consiguiente los compuestos de esta invención se pueden usar favorablemente como agentes terapéuticos para los procesos mediados por el virus de inmunodeficiencia humana (VIH. Específicamente la invención describe el uso de compuestos de fórmula I en donde (Gráfico) R1 es un C1-12- alquilo sustituido opcionalmente, arilo, heterociclilo o C1-4-alquilo sustituido con fenilo opcionalmente sustituido; R3 es C1-12-alquilo o C1-4alcoxi-C1-4-alquilo; A indica un grupo seleccionado de CH2-(aril-C1-4-alquilamino), CH2-(aril-C1-4-alcoxi), C1-4-alquilo sustituido con arilo opcionalmente sustituido o con heterociclilo opccionalmente sustituido; o A indica un grupo de fórmula CH2-U-heterociclilo, en donde U representa O, S o NR", donde R" es hidrógeno o C1-4 -alquilo; oA indica un grupo de fórmula CH(V)Z, en donde V representa OH o F, y en donde Z representa arilo o heterociclilo sustituido opcionalmente; X representa SoO; para el tratamiento de enfermedades mediadas por el virus de la inmunodeficiencia humana (VIH) o para la preparación de un medicamento para dicho tratamiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024795.7A GB0024795D0 (en) | 2000-10-10 | 2000-10-10 | Pyrazole derivatives for the treatment of viral diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034547A true ECSP034547A (es) | 2003-05-26 |
Family
ID=9900999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004547A ECSP034547A (es) | 2000-10-10 | 2003-04-08 | Derivados de pirazol para el tratamiento de enfermedades virales |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6699887B2 (es) |
| EP (1) | EP1326843A1 (es) |
| JP (1) | JP4015548B2 (es) |
| KR (1) | KR100534158B1 (es) |
| CN (2) | CN1680333A (es) |
| AR (1) | AR030858A1 (es) |
| AU (2) | AU2165102A (es) |
| BR (1) | BR0114483A (es) |
| CA (1) | CA2423515A1 (es) |
| CZ (1) | CZ20031297A3 (es) |
| EC (1) | ECSP034547A (es) |
| GB (1) | GB0024795D0 (es) |
| GT (1) | GT200100201A (es) |
| HR (1) | HRP20030251A2 (es) |
| HU (1) | HUP0302722A2 (es) |
| IL (1) | IL154875A0 (es) |
| MA (1) | MA26951A1 (es) |
| MX (1) | MXPA03003070A (es) |
| NO (1) | NO20031615L (es) |
| NZ (1) | NZ524740A (es) |
| PA (1) | PA8530301A1 (es) |
| PE (1) | PE20020750A1 (es) |
| PL (1) | PL362918A1 (es) |
| RU (1) | RU2270832C2 (es) |
| UY (1) | UY26956A1 (es) |
| WO (1) | WO2002030907A1 (es) |
| YU (1) | YU27203A (es) |
| ZA (1) | ZA200302519B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE310719T1 (de) * | 2000-09-29 | 2005-12-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| GB0113524D0 (en) | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
| EP1556381B1 (en) | 2002-09-26 | 2008-02-20 | Pfizer Limited | Pyrazole amides for treating hiv infections |
| MXPA05003195A (es) * | 2002-09-26 | 2005-06-08 | Pfizer | Derivados de pirazol como inhibidores de la transcriptasa inversa. |
| US7230025B2 (en) | 2002-09-26 | 2007-06-12 | Pfizer, Inc. | Pyrazole derivatives |
| GB0223234D0 (en) * | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| US6933312B2 (en) | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
| GB0223232D0 (en) * | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| EP1608629A1 (en) | 2003-03-24 | 2005-12-28 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| US7220772B2 (en) | 2003-09-05 | 2007-05-22 | Pfizer, Inc. | Pyrazole derivatives |
| EP1775298B1 (en) * | 2004-07-01 | 2013-03-20 | Daiichi Sankyo Company, Limited | Thienopyrazole derivative having pde7 inhibitory activity |
| US20070005049A1 (en) * | 2005-06-30 | 2007-01-04 | Comben Richard H | Apparatus and Method of Treating Urinary Incontinence by Heating Urethra |
| CN101511812A (zh) * | 2006-07-05 | 2009-08-19 | 辉瑞产品公司 | 作为细胞色素p450抑制剂的吡唑衍生物 |
| DK2057125T3 (da) | 2006-08-16 | 2011-05-16 | Hoffmann La Roche | Ikke-nucleosid revers transkriptase-inhibitorer |
| GB0713479D0 (en) * | 2007-07-11 | 2007-08-22 | Syngenta Participations Ag | Substituted aromatic heterocyclic compounds as fungicides |
| RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| GB0823000D0 (en) * | 2008-12-17 | 2009-01-28 | Syngenta Participations Ag | Isothiazole and pyrazole derivatives with plant growth regulating properties |
| NZ595233A (en) | 2009-02-25 | 2013-01-25 | Daiichi Sankyo Co Ltd | Tricyclic pyrazolopyrimidine derivatives |
| FR2951549B1 (fr) | 2009-10-15 | 2013-08-23 | Olivier Schussler | Procede d'obtention de bioprotheses medicales implantables |
| KR20130099006A (ko) | 2010-08-23 | 2013-09-05 | 다이이찌 산쿄 가부시키가이샤 | 3 고리성 피라졸로피리미딘 유도체의 프리체 결정 |
| JP5701884B2 (ja) | 2010-08-23 | 2015-04-15 | 第一三共株式会社 | 三環性ピラゾロピリミジン誘導体の結晶 |
| WO2014074628A1 (en) * | 2012-11-08 | 2014-05-15 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compounds for treating hiv and methods for using the compounds |
| US9925190B2 (en) | 2015-02-16 | 2018-03-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting HIV-1 Nef |
| JP7301042B2 (ja) | 2018-03-30 | 2023-06-30 | 住友化学株式会社 | 複素環化合物及びそれを含有する有害節足動物防除組成物 |
| WO2020081856A1 (en) * | 2018-10-18 | 2020-04-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibitors of hiv-1 nef for the treatment of hiv disease |
| FR3121927B1 (fr) | 2021-04-19 | 2023-03-31 | Eiffage Genie Civil Terrassement | Procédé d’inertage des boues d’excavation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015060A1 (fr) | 1992-01-22 | 1993-08-05 | Nissan Chemical Industries, Ltd. | Derive de pyrazole substitue et bactericide agrohorticole |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| ATE175961T1 (de) * | 1992-12-17 | 1999-02-15 | Pfizer | Pyrazole mit crf antagonistischer aktivität |
| TW336932B (en) * | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| WO1994013661A1 (en) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Substituted pyrazoles as crf antagonists |
| WO2006027423A1 (fr) * | 2004-08-09 | 2006-03-16 | Simag Developpement | Dispositif de saisie comportant un capteur optique suivi d’un moyen de filtrage |
-
2000
- 2000-10-10 GB GBGB0024795.7A patent/GB0024795D0/en not_active Ceased
-
2001
- 2001-09-20 US US09/956,656 patent/US6699887B2/en not_active Expired - Fee Related
- 2001-10-04 AU AU2165102A patent/AU2165102A/xx active Pending
- 2001-10-04 HU HU0302722A patent/HUP0302722A2/hu unknown
- 2001-10-04 RU RU2003112610/04A patent/RU2270832C2/ru not_active IP Right Cessation
- 2001-10-04 KR KR10-2003-7004984A patent/KR100534158B1/ko not_active Expired - Fee Related
- 2001-10-04 BR BR0114483-9A patent/BR0114483A/pt not_active Application Discontinuation
- 2001-10-04 MX MXPA03003070A patent/MXPA03003070A/es active IP Right Grant
- 2001-10-04 CZ CZ20031297A patent/CZ20031297A3/cs unknown
- 2001-10-04 CN CNA2005100088329A patent/CN1680333A/zh active Pending
- 2001-10-04 HR HR20030251A patent/HRP20030251A2/hr not_active Application Discontinuation
- 2001-10-04 IL IL15487501A patent/IL154875A0/xx unknown
- 2001-10-04 JP JP2002534293A patent/JP4015548B2/ja not_active Expired - Fee Related
- 2001-10-04 WO PCT/EP2001/011474 patent/WO2002030907A1/en not_active Ceased
- 2001-10-04 CN CNB018171710A patent/CN1191239C/zh not_active Expired - Fee Related
- 2001-10-04 PL PL01362918A patent/PL362918A1/xx not_active Application Discontinuation
- 2001-10-04 NZ NZ524740A patent/NZ524740A/en unknown
- 2001-10-04 EP EP01986680A patent/EP1326843A1/en not_active Withdrawn
- 2001-10-04 YU YU27203A patent/YU27203A/sh unknown
- 2001-10-04 AU AU2002221651A patent/AU2002221651B2/en not_active Ceased
- 2001-10-04 CA CA002423515A patent/CA2423515A1/en not_active Abandoned
- 2001-10-05 PE PE2001000993A patent/PE20020750A1/es not_active Application Discontinuation
- 2001-10-05 AR ARP010104697A patent/AR030858A1/es not_active Application Discontinuation
- 2001-10-09 UY UY26956A patent/UY26956A1/es not_active Application Discontinuation
- 2001-10-09 GT GT200100201A patent/GT200100201A/es unknown
- 2001-10-09 PA PA20018530301A patent/PA8530301A1/es unknown
-
2003
- 2003-03-31 ZA ZA200302519A patent/ZA200302519B/en unknown
- 2003-04-07 MA MA27096A patent/MA26951A1/fr unknown
- 2003-04-08 EC EC2003004547A patent/ECSP034547A/es unknown
- 2003-04-09 NO NO20031615A patent/NO20031615L/no unknown
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2004
- 2004-01-27 US US10/766,712 patent/US7183296B2/en not_active Expired - Fee Related
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