ATE357439T1 - Pyrazol-derivative als inhibitoren der reversen hiv-transkriptase - Google Patents
Pyrazol-derivative als inhibitoren der reversen hiv-transkriptaseInfo
- Publication number
- ATE357439T1 ATE357439T1 AT02758207T AT02758207T ATE357439T1 AT E357439 T1 ATE357439 T1 AT E357439T1 AT 02758207 T AT02758207 T AT 02758207T AT 02758207 T AT02758207 T AT 02758207T AT E357439 T1 ATE357439 T1 AT E357439T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- pyrazole derivatives
- compounds
- reverse hiv
- hiv transcriptase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113524.3A GB0113524D0 (en) | 2001-06-04 | 2001-06-04 | Pyrazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357439T1 true ATE357439T1 (de) | 2007-04-15 |
Family
ID=9915841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02758207T ATE357439T1 (de) | 2001-06-04 | 2002-05-29 | Pyrazol-derivative als inhibitoren der reversen hiv-transkriptase |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6538015B1 (de) |
| EP (1) | EP1401826B1 (de) |
| JP (1) | JP4088249B2 (de) |
| KR (1) | KR100627532B1 (de) |
| CN (1) | CN1249052C (de) |
| AT (1) | ATE357439T1 (de) |
| AU (1) | AU2002325221B2 (de) |
| BR (1) | BR0210158A (de) |
| CA (1) | CA2448058C (de) |
| DE (1) | DE60219009T2 (de) |
| DK (1) | DK1401826T3 (de) |
| ES (1) | ES2282446T3 (de) |
| GB (1) | GB0113524D0 (de) |
| MX (1) | MXPA03011199A (de) |
| PT (1) | PT1401826E (de) |
| WO (1) | WO2002100853A1 (de) |
| ZA (1) | ZA200308781B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| JP4993407B2 (ja) | 2004-08-04 | 2012-08-08 | 大正製薬株式会社 | トリアゾール誘導体 |
| JP2008526828A (ja) * | 2005-01-06 | 2008-07-24 | ファイザー・リミテッド | 逆転写酵素モジュレーターとしてのイミダゾール誘導体 |
| CN101415691B (zh) | 2006-02-03 | 2011-12-14 | 大正制药株式会社 | 三唑衍生物 |
| EP1988081B1 (de) | 2006-02-06 | 2012-10-17 | Taisho Pharmaceutical Co., Ltd | Bindungsinhibitor von sphingosin-1-phosphat |
| ES2360893T3 (es) | 2006-08-16 | 2011-06-10 | F. Hoffmann-La Roche Ag | Inhibidores no nucleósidos de la transcriptasa inversa. |
| AU2008267895A1 (en) | 2007-06-22 | 2008-12-31 | F. Hoffmann-La Roche Ag | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
| US8048898B2 (en) | 2007-08-01 | 2011-11-01 | Taisho Pharmaceutical Co., Ltd | Inhibitor of binding of S1P1 |
| AU2008340422B2 (en) | 2007-12-21 | 2014-06-19 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| EP2295038B1 (de) * | 2009-09-11 | 2013-05-29 | AiCuris GmbH & Co. KG | Festdispergierung mit einem Anti-HIV-Wirkstoff |
| ES2528646T3 (es) * | 2010-05-20 | 2015-02-11 | Bayer Intellectual Property Gmbh | Procedimiento para la fabricación de 1-alquil-3-difluorometil-5-hidroxipirazoles |
| JP5722891B2 (ja) | 2010-07-15 | 2015-05-27 | 大日本住友製薬株式会社 | ピラゾール化合物 |
| US9695127B2 (en) | 2012-11-08 | 2017-07-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compounds for treating HIV and methods for using the compounds |
| US9925190B2 (en) | 2015-02-16 | 2018-03-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting HIV-1 Nef |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015060A1 (en) | 1992-01-22 | 1993-08-05 | Nissan Chemical Industries, Ltd. | Substituted pyrazole derivative and agrohorticultural bactericide |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| CA2200316C (en) | 1994-09-26 | 2004-09-21 | Hirohiko Sugimoto | Imidazole derivative |
| US5698495A (en) | 1995-11-15 | 1997-12-16 | Zeneca Limited | Herbicidal substituted pyrazole compounds |
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) * | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
-
2001
- 2001-06-04 GB GBGB0113524.3A patent/GB0113524D0/en not_active Ceased
-
2002
- 2002-05-24 US US10/154,585 patent/US6538015B1/en not_active Expired - Fee Related
- 2002-05-29 DK DK02758207T patent/DK1401826T3/da active
- 2002-05-29 WO PCT/EP2002/005898 patent/WO2002100853A1/en active IP Right Grant
- 2002-05-29 CN CNB028111974A patent/CN1249052C/zh not_active Expired - Fee Related
- 2002-05-29 KR KR1020037015833A patent/KR100627532B1/ko not_active IP Right Cessation
- 2002-05-29 EP EP02758207A patent/EP1401826B1/de not_active Expired - Lifetime
- 2002-05-29 MX MXPA03011199A patent/MXPA03011199A/es active IP Right Grant
- 2002-05-29 AT AT02758207T patent/ATE357439T1/de not_active IP Right Cessation
- 2002-05-29 JP JP2003503620A patent/JP4088249B2/ja not_active Expired - Fee Related
- 2002-05-29 DE DE60219009T patent/DE60219009T2/de not_active Expired - Fee Related
- 2002-05-29 CA CA002448058A patent/CA2448058C/en not_active Expired - Fee Related
- 2002-05-29 PT PT02758207T patent/PT1401826E/pt unknown
- 2002-05-29 AU AU2002325221A patent/AU2002325221B2/en not_active Ceased
- 2002-05-29 BR BR0210158-0A patent/BR0210158A/pt not_active IP Right Cessation
- 2002-05-29 ES ES02758207T patent/ES2282446T3/es not_active Expired - Lifetime
-
2003
- 2003-11-11 ZA ZA200308781A patent/ZA200308781B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1401826B1 (de) | 2007-03-21 |
| CN1527829A (zh) | 2004-09-08 |
| WO2002100853A1 (en) | 2002-12-19 |
| KR100627532B1 (ko) | 2006-09-21 |
| JP4088249B2 (ja) | 2008-05-21 |
| DE60219009T2 (de) | 2007-12-13 |
| JP2004532276A (ja) | 2004-10-21 |
| CA2448058A1 (en) | 2002-12-19 |
| DE60219009D1 (de) | 2007-05-03 |
| BR0210158A (pt) | 2004-06-08 |
| AU2002325221B2 (en) | 2008-07-31 |
| KR20040003050A (ko) | 2004-01-07 |
| ZA200308781B (en) | 2005-02-11 |
| EP1401826A1 (de) | 2004-03-31 |
| PT1401826E (pt) | 2007-06-19 |
| ES2282446T3 (es) | 2007-10-16 |
| DK1401826T3 (da) | 2007-07-30 |
| US6538015B1 (en) | 2003-03-25 |
| MXPA03011199A (es) | 2004-02-26 |
| GB0113524D0 (en) | 2001-07-25 |
| CA2448058C (en) | 2008-12-23 |
| CN1249052C (zh) | 2006-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU27203A (sh) | Pirazol derivati za tretiranje virusnih oboljenja | |
| ATE357439T1 (de) | Pyrazol-derivative als inhibitoren der reversen hiv-transkriptase | |
| EA200300943A1 (ru) | Производные пиразола для лечения инфекции вируса иммунодефицита человека (вич) | |
| CY1106207T1 (el) | Αντιιικα παραγωγα νουκλεοζιτων | |
| BRPI0511982A (pt) | compostos antiviróticos heterocìclicos | |
| DE60318891D1 (de) | Cyclopropylverbindungen als ccr5 antagonisten | |
| HUP0303082A2 (hu) | Szubsztituált indolil-oxo-acetil-piperazinszármazékok, ezeket tartalmazó készítmények és vírusellenes alkalmazásuk | |
| MXPA05010210A (es) | Inhibidores no nucleosidos de transcriptasa inversa para tratar las enfermedades mediadas por el virus de la inmunodeficiencia humana (vih). | |
| WO2002079186A3 (en) | Aminopiperidine derivatives as modulators of chemokine receptor activity | |
| MXPA02012409A (es) | Derivados de pirrol para tratamiento del sida. | |
| ATE384714T1 (de) | Pyrazolderivate | |
| ATE374775T1 (de) | Inhibitoren des hiv-integrase-enzyms | |
| DK1404656T3 (da) | Derivater af benzimidazol til behandling af sygdomme forbundet med en aktivering af mikroglia, såsom inflammatoriske, allergiske, inficerende eller autoimmune sygdomme | |
| ATE386741T1 (de) | Pyrazolamide zur behandlung von hiv-infektionen | |
| EA200500287A1 (ru) | Производные 4-(3, 5-дицианофенокси)пиразола для применения в качестве модуляторов обратной транскриптазы в лечении, в числе прочего, вич-инфекции | |
| HUP0203161A2 (hu) | Benzamidinszármazékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| BR0115476A (pt) | Derivados de imidazolona para o tratamento de doenças virais | |
| EA202192111A1 (ru) | Новые тритерпеновые производные в качестве ингибиторов вич | |
| AU2003264940A1 (en) | Pyrazole derivatives and their use as therapeutic agents for hiv mediated diseases | |
| AP1846A (en) | Pyrazole Derivatives. | |
| UA31078A (uk) | Інгібітор вірусу імунодефіциту людини ( даримід ) | |
| WO2005028442A3 (en) | 2-pyridinone derivatives, having hiv inhibiting properties |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1401826 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |