BR0115476A - Derivados de imidazolona para o tratamento de doenças virais - Google Patents

Derivados de imidazolona para o tratamento de doenças virais

Info

Publication number
BR0115476A
BR0115476A BR0115476-1A BR0115476A BR0115476A BR 0115476 A BR0115476 A BR 0115476A BR 0115476 A BR0115476 A BR 0115476A BR 0115476 A BR0115476 A BR 0115476A
Authority
BR
Brazil
Prior art keywords
compounds
treatment
formula
imidazolone derivatives
viral diseases
Prior art date
Application number
BR0115476-1A
Other languages
English (en)
Inventor
Brian William Dymock
Philip Stephen Jones
John Herbert Merrett
Kevin Edward Burndon Parkes
Martin John Parratt
Daryl Simon Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0115476A publication Critical patent/BR0115476A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS DE IMIDAZOLONA PARA O TRATAMENTO DE DOENçAS VIRAIS". A invenção refere-se a novos derivados de imidazolona, assim como ésteres ou éteres hidrolizáveis de compostos de fórmula I e sais farmaceuticamente aceitáveis destes, um processo para a sua fabricação, composições farmacêuticas e o uso de tais compostos na medicina (fórmula I), em que R^ 1^, R^ 2^, R^ 3^, A e X são como definidos na descrição. Os compostos de fórmula I são a enzima da transcriptase reversa do vírus da imunodeficiência humana que é envolvida na replicação viral. Conseq³entemente os compostos desta invenção podem ser vantajosamente usados como agentes terapêuticos para o processo mediado pelo HIV.
BR0115476-1A 2000-11-22 2001-11-12 Derivados de imidazolona para o tratamento de doenças virais BR0115476A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0028484.4A GB0028484D0 (en) 2000-11-22 2000-11-22 Imidazolone derivatives for the treatment of viral diseases
PCT/EP2001/013069 WO2002042279A1 (en) 2000-11-22 2001-11-12 Imidazolone derivatives for the treatment of viral diseases

Publications (1)

Publication Number Publication Date
BR0115476A true BR0115476A (pt) 2003-08-19

Family

ID=9903671

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115476-1A BR0115476A (pt) 2000-11-22 2001-11-12 Derivados de imidazolona para o tratamento de doenças virais

Country Status (20)

Country Link
US (1) US6518293B2 (pt)
EP (1) EP1341766B1 (pt)
JP (1) JP2004514672A (pt)
KR (1) KR100528760B1 (pt)
CN (1) CN1633417A (pt)
AR (1) AR035372A1 (pt)
AT (1) ATE307805T1 (pt)
AU (2) AU2184202A (pt)
BR (1) BR0115476A (pt)
CA (1) CA2428461A1 (pt)
DE (1) DE60114448T2 (pt)
DK (1) DK1341766T3 (pt)
ES (1) ES2251529T3 (pt)
GB (1) GB0028484D0 (pt)
MX (1) MXPA03004454A (pt)
PA (1) PA8533301A1 (pt)
PE (1) PE20020636A1 (pt)
UY (1) UY27035A1 (pt)
WO (1) WO2002042279A1 (pt)
ZA (1) ZA200303690B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
US20080132549A1 (en) * 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
CA2592909A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
WO2008085008A1 (en) * 2007-01-11 2008-07-17 Mogam Biotechnology Research Institute T-cell inhibiting compounds and their use for the treatment of t-cell-mediated diseases
KR101110120B1 (ko) * 2009-10-28 2012-01-31 주식회사 케이아이테크놀로지 표지판 완충장치

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345936A (en) * 1981-10-05 1982-08-24 Eli Lilly And Company Imidazoles, compositions and herbicidal method
TW235963B (pt) 1992-01-16 1994-12-11 Shionogi & Co
EP0627423A4 (en) 1992-01-22 1995-02-15 Nissan Chemical Ind Ltd SUBSTITUTED PYRAZOLE DERIVATIVES AND BACTERICIDES FOR AGRICULTURE AND GARDENING.
GB9222262D0 (en) 1992-10-23 1992-12-09 Merck Sharp & Dohme Therapeutic agents
US5612636A (en) * 1995-01-19 1997-03-18 Texas Instruments Incorporated Short circuit power optimization for CMOS circuits
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US6046331A (en) * 1998-12-17 2000-04-04 Synaptic Pharmaceutical Corporation Imidazolones and their use in treating benign prostatic hyperplasia and other disorders

Also Published As

Publication number Publication date
DE60114448T2 (de) 2006-07-06
AU2184202A (en) 2002-06-03
ATE307805T1 (de) 2005-11-15
EP1341766A1 (en) 2003-09-10
PE20020636A1 (es) 2002-07-18
EP1341766B1 (en) 2005-10-26
AU2002221842B2 (en) 2007-08-23
US6518293B2 (en) 2003-02-11
CA2428461A1 (en) 2002-05-30
ES2251529T3 (es) 2006-05-01
WO2002042279A1 (en) 2002-05-30
UY27035A1 (es) 2002-06-20
AR035372A1 (es) 2004-05-12
GB0028484D0 (en) 2001-01-10
MXPA03004454A (es) 2003-08-19
KR20030060951A (ko) 2003-07-16
KR100528760B1 (ko) 2005-11-15
DE60114448D1 (de) 2005-12-01
US20020107272A1 (en) 2002-08-08
CN1633417A (zh) 2005-06-29
PA8533301A1 (es) 2002-08-26
JP2004514672A (ja) 2004-05-20
ZA200303690B (en) 2004-08-13
DK1341766T3 (da) 2006-02-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 233/86, 233/78, 401/12, 401/06; A61K 31/4164, 31/4174, 31/4427; A61P 31/00

Ipc: C07D 233/86 (2011.01), C07D 233/78 (2011.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 8A, 9AE 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.