BR0112241A - Derivados de pirrol para o tratamento de aids - Google Patents

Derivados de pirrol para o tratamento de aids

Info

Publication number
BR0112241A
BR0112241A BR0112241-0A BR0112241A BR0112241A BR 0112241 A BR0112241 A BR 0112241A BR 0112241 A BR0112241 A BR 0112241A BR 0112241 A BR0112241 A BR 0112241A
Authority
BR
Brazil
Prior art keywords
alkyl
aryl
hydrogen
heterocyclyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
BR0112241-0A
Other languages
English (en)
Inventor
Brian William Dymock
Philip Stephen Jones
John Herbert Merrett
Martin John Parratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann-La Roche AG
Hoffmann-La Roche Inc
Original Assignee
F Hoffmann-La Roche AG
Hoffmann-La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann-La Roche AG, Hoffmann-La Roche Inc filed Critical F Hoffmann-La Roche AG
Publication of BR0112241A publication Critical patent/BR0112241A/pt
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"DERIVADOS DE PIRROL PARA O TRATAMENTO DE AIDS". A invenção refere-se a novos derivados de pirrol, um processo para a sua fabricação, composições farmacêuticas e o uso de tais compostos na medicina. Em particular, os compostos de fórmula (I) são inibidores da enzima transcriptase reversa do vírus da imunodeficiência humana que é envolvida na reprodução viral. Conseq³entemente os compostos desta invenção podem ser vantajosamente usados como agentes terapêuticos para o processo mediado pelo HIV. A invenção descreve novos compostos de fórmula (I) em que R^ 1^ é alquila, cicloalquila, arila ou heterociclila; R^ 2^ é alquila, cicloalquila, arila ou heterociclila; R^ 3^ é hidrogênio, alquila, cicloalquila, arila ou heterociclila; R^ 4^ é hidrogênio , alquila, carboxila, C(=O)R, CONR'R", ciano ou alquenila, em que R é hidrogênio, alquila, alcóxi, trifluorometila, metil-óxi-carbonila ou etil-óxi-carbonila, e em que R' e R", são independentemente um do outro, hidrogênio, alquila ou arila; R^ 5^ é alquila, arila ou um grupo -Z-C(=O)R"', em que Z é uma ligação única ou CH=CH-, e em que R"' é hidrogênio ou alquila; X representa S, S(O), S(O)~ 2~, O, N(alquila) ou X-R^ 2^ juntamente representam CH~ 2~-arila ou CH~ 2~heterociclila; e sob a condição que somente um de R^ 3^ e R^ 4^ é hidrogênio e alquila em R^ 3^ não é CF~ 3~; e ésteres ou éteres hidrolisáveis destes ou um sal farmaceuticamente aceitável destes.
BR0112241-0A 2000-07-04 2001-04-30 Derivados de pirrol para o tratamento de aids Withdrawn BR0112241A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0016453.3A GB0016453D0 (en) 2000-07-04 2000-07-04 Pyrrole derivatives
PCT/EP2001/004832 WO2002002524A1 (en) 2000-07-04 2001-04-30 Pyrrole derivatives for treating aids

Publications (1)

Publication Number Publication Date
BR0112241A true BR0112241A (pt) 2003-06-24

Family

ID=9895031

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112241-0A Withdrawn BR0112241A (pt) 2000-07-04 2001-04-30 Derivados de pirrol para o tratamento de aids

Country Status (17)

Country Link
US (1) US6737429B2 (pt)
EP (1) EP1301481A1 (pt)
JP (1) JP2004502674A (pt)
KR (1) KR100549884B1 (pt)
CN (1) CN1440385A (pt)
AR (1) AR028602A1 (pt)
AU (2) AU2001263874B2 (pt)
BR (1) BR0112241A (pt)
CA (1) CA2412270A1 (pt)
EC (1) ECSP014109A (pt)
GB (1) GB0016453D0 (pt)
GT (1) GT200100111A (pt)
MX (1) MXPA02012409A (pt)
PA (1) PA8516201A1 (pt)
PE (1) PE20020269A1 (pt)
UY (1) UY26720A1 (pt)
WO (1) WO2002002524A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1405849A1 (en) * 2002-10-04 2004-04-07 Corning Incorporated Halogenated styrene compounds and low-absorption-loss polymers obtainable therefrom
KR101122708B1 (ko) * 2003-12-26 2012-03-26 마사토시 하기와라 Ｓｒ 단백질 인산화 제어 방법, 및 유효성분으로서 ｓｒ 단백질 활성 제어제를 함유하는 항바이러스제
ES2402362T3 (es) 2004-09-30 2013-05-03 Takeda Pharmaceutical Company Limited Inhibidores de la bomba de protones
TW200628446A (en) * 2004-12-14 2006-08-16 Takeda Pharmaceuticals Co Substituted pyrrole derivative
US20080176919A1 (en) * 2005-01-06 2008-07-24 Pfizer Inc Imidazole Derivatives As Enzyme Reverse Transcriptase Modulators
CA2621182C (en) 2005-08-30 2014-03-18 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors
US20100113421A1 (en) * 2006-10-06 2010-05-06 Williams Theresa M Non-nucleoside reverse transcriptase inhibitors
US20080242648A1 (en) * 2006-11-10 2008-10-02 Syndax Pharmaceuticals, Inc., A California Corporation COMBINATION OF ERa+ LIGANDS AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
WO2009015180A2 (en) * 2007-07-23 2009-01-29 Syndax Pharmaceuticals, Inc. Novel compounds and methods of using them
SG10201602750RA (en) * 2007-10-16 2016-05-30 Nikon Corp Illumination Optical System, Exposure Apparatus, And Device Manufacturing Method
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
NZ591793A (en) 2008-08-27 2012-11-30 Takeda Pharmaceutical Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds
GB0823001D0 (en) * 2008-12-17 2009-01-28 Syngenta Participations Ag Thiophene,furan and pyrrole derivatives with plant growth regulating properties
CN101775011B (zh) * 2009-01-13 2013-07-31 中国人民解放军军事医学科学院毒物药物研究所 N-取代苯基-3-甲烯杂环芳烃-2,5-二甲基吡咯类化合物及其抗hiv/aids的应用
CN114727987A (zh) * 2019-11-19 2022-07-08 纽约血库公司 具有hiv治疗活性的经取代杂环化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644631A (en) * 1969-05-13 1972-02-22 Endo Lab Therapeutic methods utilizing aryl pyrrol-3-yl ketones
US4282242A (en) * 1980-03-07 1981-08-04 Pfizer Inc. Antidiabetic pyrrolecarboxylic acids
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
JP2781661B2 (ja) * 1992-12-17 1998-07-30 フアイザー・インコーポレイテツド Ｃｒｆアンタゴニストとしての置換ピラゾール
JP3291299B2 (ja) * 1994-06-06 2002-06-10 ファイザー・インク コルチコトロピン放出因子（ｃｒｆ）アンタゴニスト活性を有する置換ピラゾール
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
US6417202B1 (en) * 1996-07-11 2002-07-09 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin-and TNF antagonists
DE19963174A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen

Also Published As

Publication number Publication date
US6737429B2 (en) 2004-05-18
EP1301481A1 (en) 2003-04-16
PA8516201A1 (es) 2002-07-30
KR20030014321A (ko) 2003-02-15
AU2001263874B2 (en) 2006-10-19
AR028602A1 (es) 2003-05-14
ECSP014109A (es) 2002-02-25
GT200100111A (es) 2002-03-18
UY26720A1 (es) 2001-11-30
KR100549884B1 (ko) 2006-02-06
JP2004502674A (ja) 2004-01-29
CN1440385A (zh) 2003-09-03
CA2412270A1 (en) 2002-01-10
MXPA02012409A (es) 2003-04-25
US20020032221A1 (en) 2002-03-14
AU6387401A (en) 2002-01-14
PE20020269A1 (es) 2002-04-08
WO2002002524A1 (en) 2002-01-10
GB0016453D0 (en) 2000-08-23

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009.