PE20020269A1 - Derivados de pirrol como inhibidores de transcriptasa inversa del vih - Google Patents
Derivados de pirrol como inhibidores de transcriptasa inversa del vihInfo
- Publication number
- PE20020269A1 PE20020269A1 PE2001000487A PE2001000487A PE20020269A1 PE 20020269 A1 PE20020269 A1 PE 20020269A1 PE 2001000487 A PE2001000487 A PE 2001000487A PE 2001000487 A PE2001000487 A PE 2001000487A PE 20020269 A1 PE20020269 A1 PE 20020269A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- aryl
- inhibitors
- reverse transcriptase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRROL DE FORMULA I DONDE R1 Y R2 SON ALQUILO, CICLOALQUILO, ARILO, HETEROCICLO; R3 ES H, ALQUILO, CICLOALQUILO, ARILO, HETEROCICLO; R4 ES H, ALQUILO, CARBOXILO, C=OR, CONR'R'", CN, ALQUENILO; R ES H, ALQUILO, ALCOXILO, TRIFLUOROMETILO, METIL-OXI-CARBONILO, ETIL-OXI-CARBONILO; R' Y R" SON H, ALQUILO, ARILO; R5 ES ALQUILO, ARILO, Z-C(=O)R"'; Z ES ENLACE, HC=CH; R2'" ES H, ALQUILO; X ES S, SO, SO2, N-ALQUILO; X-R2 EN CONJUNTO ES CH2-ARILO, CH2-HETEROCICLO; UNO DE R3 Y R4 ES H Y ALQUILO EN R3 NO ES CF3. SON COMPUESTOS PREFERIDOS 5-(3,5-DICLOROFENIL-TIO)-4-ISOPROPIL-2-METIL-1-[(3-PIRIDIL)METIL]-1H-PIRROL-3-METANOL, 4-ISOPROPIL-2-METIL-5-FENILTIO-1-[(4-PIRIDIL)-METIL]-1H-PIRROL-3-METANOL, ENTRE OTROS, TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA TRANSCRIPTASA INVERSA Y PUEDE SER UTIL PARA EL TRATAMIENTO EL VIH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0016453.3A GB0016453D0 (en) | 2000-07-04 | 2000-07-04 | Pyrrole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020269A1 true PE20020269A1 (es) | 2002-04-08 |
Family
ID=9895031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000487A PE20020269A1 (es) | 2000-07-04 | 2001-05-25 | Derivados de pirrol como inhibidores de transcriptasa inversa del vih |
Country Status (17)
Country | Link |
---|---|
US (1) | US6737429B2 (es) |
EP (1) | EP1301481A1 (es) |
JP (1) | JP2004502674A (es) |
KR (1) | KR100549884B1 (es) |
CN (1) | CN1440385A (es) |
AR (1) | AR028602A1 (es) |
AU (2) | AU6387401A (es) |
BR (1) | BR0112241A (es) |
CA (1) | CA2412270A1 (es) |
EC (1) | ECSP014109A (es) |
GB (1) | GB0016453D0 (es) |
GT (1) | GT200100111A (es) |
MX (1) | MXPA02012409A (es) |
PA (1) | PA8516201A1 (es) |
PE (1) | PE20020269A1 (es) |
UY (1) | UY26720A1 (es) |
WO (1) | WO2002002524A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1405849A1 (en) * | 2002-10-04 | 2004-04-07 | Corning Incorporated | Halogenated styrene compounds and low-absorption-loss polymers obtainable therefrom |
KR101122708B1 (ko) * | 2003-12-26 | 2012-03-26 | 마사토시 하기와라 | Sr 단백질 인산화 제어 방법, 및 유효성분으로서 sr 단백질 활성 제어제를 함유하는 항바이러스제 |
JP5173192B2 (ja) | 2004-09-30 | 2013-03-27 | 武田薬品工業株式会社 | プロトンポンプ阻害薬 |
TW200628446A (en) * | 2004-12-14 | 2006-08-16 | Takeda Pharmaceuticals Co | Substituted pyrrole derivative |
EP1838679A1 (en) * | 2005-01-06 | 2007-10-03 | Pfizer Limited | Imidazole derivatives as enzyme reverse transcriptase modulators |
US7977488B2 (en) | 2005-08-30 | 2011-07-12 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors |
WO2008054605A2 (en) * | 2006-10-06 | 2008-05-08 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
EP2099443A4 (en) * | 2006-11-10 | 2010-05-05 | Syndax Pharmaceuticals Inc | ASSOCIATION OF ERA + LIGANDS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF CANCER |
US8933105B2 (en) | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
WO2009015180A2 (en) * | 2007-07-23 | 2009-01-29 | Syndax Pharmaceuticals, Inc. | Novel compounds and methods of using them |
KR101546987B1 (ko) * | 2007-10-16 | 2015-08-24 | 가부시키가이샤 니콘 | 조명 광학 시스템, 노광 장치 및 디바이스 제조 방법 |
US20090131367A1 (en) * | 2007-11-19 | 2009-05-21 | The Regents Of The University Of Colorado | Combinations of HDAC Inhibitors and Proteasome Inhibitors |
NZ591793A (en) | 2008-08-27 | 2012-11-30 | Takeda Pharmaceutical | Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds |
GB0823001D0 (en) * | 2008-12-17 | 2009-01-28 | Syngenta Participations Ag | Thiophene,furan and pyrrole derivatives with plant growth regulating properties |
CN101775011B (zh) * | 2009-01-13 | 2013-07-31 | 中国人民解放军军事医学科学院毒物药物研究所 | N-取代苯基-3-甲烯杂环芳烃-2,5-二甲基吡咯类化合物及其抗hiv/aids的应用 |
EP4061360A4 (en) * | 2019-11-19 | 2023-07-05 | New York Blood Center, Inc. | SUBSTITUTED HETEROCYCLIC COMPOUNDS SHOWING THERAPEUTIC ACTIVITY AGAINST HIV |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3644631A (en) * | 1969-05-13 | 1972-02-22 | Endo Lab | Therapeutic methods utilizing aryl pyrrol-3-yl ketones |
US4282242A (en) * | 1980-03-07 | 1981-08-04 | Pfizer Inc. | Antidiabetic pyrrolecarboxylic acids |
US4347186A (en) * | 1980-10-20 | 1982-08-31 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein |
DK0674631T3 (da) * | 1992-12-17 | 2000-04-10 | Pfizer | Substituerede pyrazoler som CRF-antogonister |
US5968944A (en) * | 1994-06-06 | 1999-10-19 | Pfizer Inc. | Substituted pyrazoles as corticotropin-releasing factor (CRF) antagonists |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
US6417202B1 (en) * | 1996-07-11 | 2002-07-09 | Pfizer Inc. | Pyridylpyrrole compounds useful as interleukin-and TNF antagonists |
DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
-
2000
- 2000-07-04 GB GBGB0016453.3A patent/GB0016453D0/en not_active Ceased
-
2001
- 2001-04-30 CA CA002412270A patent/CA2412270A1/en not_active Abandoned
- 2001-04-30 AU AU6387401A patent/AU6387401A/xx active Pending
- 2001-04-30 BR BR0112241-0A patent/BR0112241A/pt not_active Withdrawn
- 2001-04-30 CN CN01812290A patent/CN1440385A/zh active Pending
- 2001-04-30 KR KR1020037000138A patent/KR100549884B1/ko not_active IP Right Cessation
- 2001-04-30 MX MXPA02012409A patent/MXPA02012409A/es active IP Right Grant
- 2001-04-30 WO PCT/EP2001/004832 patent/WO2002002524A1/en not_active Application Discontinuation
- 2001-04-30 JP JP2002507781A patent/JP2004502674A/ja active Pending
- 2001-04-30 EP EP01938137A patent/EP1301481A1/en not_active Withdrawn
- 2001-04-30 AU AU2001263874A patent/AU2001263874B2/en not_active Ceased
- 2001-05-04 PA PA20018516201A patent/PA8516201A1/es unknown
- 2001-05-18 UY UY26720A patent/UY26720A1/es not_active Application Discontinuation
- 2001-05-22 AR ARP010102414A patent/AR028602A1/es not_active Application Discontinuation
- 2001-05-25 PE PE2001000487A patent/PE20020269A1/es not_active Application Discontinuation
- 2001-06-12 GT GT200100111A patent/GT200100111A/es unknown
- 2001-06-13 US US09/880,534 patent/US6737429B2/en not_active Expired - Fee Related
- 2001-07-04 EC EC2001004109A patent/ECSP014109A/es unknown
Also Published As
Publication number | Publication date |
---|---|
GB0016453D0 (en) | 2000-08-23 |
UY26720A1 (es) | 2001-11-30 |
CA2412270A1 (en) | 2002-01-10 |
US20020032221A1 (en) | 2002-03-14 |
AU2001263874B2 (en) | 2006-10-19 |
KR100549884B1 (ko) | 2006-02-06 |
WO2002002524A1 (en) | 2002-01-10 |
AR028602A1 (es) | 2003-05-14 |
GT200100111A (es) | 2002-03-18 |
US6737429B2 (en) | 2004-05-18 |
AU6387401A (en) | 2002-01-14 |
MXPA02012409A (es) | 2003-04-25 |
CN1440385A (zh) | 2003-09-03 |
BR0112241A (pt) | 2003-06-24 |
KR20030014321A (ko) | 2003-02-15 |
EP1301481A1 (en) | 2003-04-16 |
ECSP014109A (es) | 2002-02-25 |
PA8516201A1 (es) | 2002-07-30 |
JP2004502674A (ja) | 2004-01-29 |
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Legal Events
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