PE20040581A1 - Inhibidores heterociclicos de cinasas - Google Patents
Inhibidores heterociclicos de cinasasInfo
- Publication number
- PE20040581A1 PE20040581A1 PE2003000622A PE2003000622A PE20040581A1 PE 20040581 A1 PE20040581 A1 PE 20040581A1 PE 2003000622 A PE2003000622 A PE 2003000622A PE 2003000622 A PE2003000622 A PE 2003000622A PE 20040581 A1 PE20040581 A1 PE 20040581A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase inhibitors
- pyridin
- methyl
- compounds
- heterocyclic kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS FARMACEUTICOS DE FORMULA I DONDE A Y B SON CADA UNO ARILO, HETEROALRILO, HETEROCICLO, ENTRE OTROS; X E Y SON CADA UNO R1CR2, S, O, SO2, ENTRE OTROS; D ES S, O Y NR4; R1, R2 Y R4 SON CADA UNO H, ALQUILO, HETEROCICLO, ENTRE OTROS. SUS COMPUESTOS PREFERIDOS SON: 2,4-DIFLUORO-N-METIL-5-{[2-(PIRIDIN-2-ILAMINO)-TIAZOL-5-ILMETIL]-AMINO}-BENZAMIDA Y 4-FLUORO-N-METIL-3-{[2-(PIRIDIN-2-ILAMINO)-TIAZOL-5-ILMETIL]-AMINO}-BENZAMIDA; ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE TIROSINA CINASA Y SON UTILES EN EL TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39081302P | 2002-06-20 | 2002-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040581A1 true PE20040581A1 (es) | 2004-09-08 |
Family
ID=30000629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000622A PE20040581A1 (es) | 2002-06-20 | 2003-06-20 | Inhibidores heterociclicos de cinasas |
Country Status (14)
Country | Link |
---|---|
US (2) | US7084160B2 (es) |
EP (1) | EP1513818B1 (es) |
JP (1) | JP4477492B2 (es) |
AR (1) | AR040272A1 (es) |
AT (1) | ATE455767T1 (es) |
AU (1) | AU2003251559A1 (es) |
DE (1) | DE60331061D1 (es) |
ES (1) | ES2337246T3 (es) |
IS (1) | IS7599A (es) |
NO (1) | NO330043B1 (es) |
PE (1) | PE20040581A1 (es) |
PL (1) | PL374272A1 (es) |
TW (1) | TW200401638A (es) |
WO (1) | WO2004001059A2 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
NZ537208A (en) * | 2002-06-27 | 2009-02-28 | Adipogen Pharmaceuticals Pty Ltd | Differentiation modulating agents and uses therefor |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
PT1767535E (pt) * | 2002-08-23 | 2010-02-24 | Sloan Kettering Inst Cancer | Síntese de epotilonas, respectivos intermediários, análogos e suas utilizações |
ATE538787T1 (de) * | 2003-07-11 | 2012-01-15 | Merck Patent Gmbh | Benzimidazol-derivative als raf-kinase-hemmer |
US7718676B2 (en) * | 2003-10-23 | 2010-05-18 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
US7449167B2 (en) * | 2004-07-08 | 2008-11-11 | Air Products And Chemicals, Inc. | Catalyst and process for improving the adiabatic steam-reforming of natural gas |
WO2006102557A2 (en) | 2005-03-22 | 2006-09-28 | The President And Fellows Of Harvard College | Treatment of protein degradation disorders |
EP2361624A1 (en) * | 2005-04-04 | 2011-08-31 | AB Science | Oxazole derivatives and their use as tyrosine kinase inhibitors |
WO2006134989A1 (ja) * | 2005-06-15 | 2006-12-21 | Kyowa Hakko Kogyo Co., Ltd. | 含窒素複素環化合物 |
US8337721B2 (en) | 2005-12-02 | 2012-12-25 | Vanderbilt University | Broad-emission nanocrystals and methods of making and using same |
CA2633756C (en) | 2005-12-21 | 2015-11-24 | Micromet Ag | Pharmaceutical antibody compositions with resistance to soluble cea |
AU2006328186A1 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Chemical compounds |
JP5441416B2 (ja) | 2006-02-14 | 2014-03-12 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二官能性ヒストンデアセチラーゼインヒビター |
CA2642288C (en) | 2006-02-14 | 2014-10-07 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors |
AU2007238785B2 (en) * | 2006-04-13 | 2013-02-07 | Agnieszka Ambrozak | Tetrahalogenated compounds useful as inhibitors of angiogenesis |
AU2007248656B2 (en) | 2006-05-03 | 2013-04-04 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase and tubulin deacetylase inhibitors |
ES2427924T3 (es) | 2006-06-30 | 2013-11-04 | Merck Sharp & Dohme Corp. | Biomarcador IGFBP2 |
WO2008060907A2 (en) | 2006-11-10 | 2008-05-22 | Bristol-Myers Squibb Company | Pyrrolo-pyridine kinase inhibitors |
EP2111402B1 (en) * | 2007-01-05 | 2012-03-07 | Bristol-Myers Squibb Company | Aminopyrazole kinase inhibitors |
EP2117531B1 (en) * | 2007-01-12 | 2016-11-02 | AB Science | Combination treatment of solid cancers with antimetabolites and tyrosine kinase inhibitors |
MX2010003606A (es) | 2007-10-01 | 2010-07-02 | Isis Pharmaceuticals Inc | Modulacion antisentido de la expresion del receptor del factor de crecimiento fibroblastico 4. |
UY31432A1 (es) | 2007-10-26 | 2009-05-29 | Compuestos de diarilhidantoina | |
US8440716B2 (en) | 2008-07-23 | 2013-05-14 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815784D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815782D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
EP2400985A2 (en) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor |
US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
EP2519517B1 (en) | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
CA2839437A1 (en) | 2011-06-16 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US20170349540A1 (en) * | 2014-07-28 | 2017-12-07 | The General Hospital Corporation | Histone deacetylase inhibitors |
JP6861166B2 (ja) | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
JP7028766B2 (ja) * | 2015-09-09 | 2022-03-02 | ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0841008A (ja) * | 1994-07-29 | 1996-02-13 | Ono Pharmaceut Co Ltd | 一酸化窒素合成酵素阻害剤 |
US6262096B1 (en) * | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
JP2002518380A (ja) * | 1998-06-18 | 2002-06-25 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤 |
US6214852B1 (en) * | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6515004B1 (en) * | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
DK1497019T3 (en) * | 2002-04-23 | 2015-08-03 | Bristol Myers Squibb Co | PYRROLO-TRIAZINANILINE COMPOSITIONS USED AS KINase INHIBITORS |
JP2005529890A (ja) * | 2002-04-23 | 2005-10-06 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なアリールケトンピロロトリアジン化合物 |
TW200400034A (en) * | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
WO2004013145A1 (en) * | 2002-08-02 | 2004-02-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
-
2003
- 2003-06-16 TW TW092116280A patent/TW200401638A/zh unknown
- 2003-06-18 ES ES03761106T patent/ES2337246T3/es not_active Expired - Lifetime
- 2003-06-18 AT AT03761106T patent/ATE455767T1/de not_active IP Right Cessation
- 2003-06-18 PL PL03374272A patent/PL374272A1/xx not_active Application Discontinuation
- 2003-06-18 WO PCT/US2003/019243 patent/WO2004001059A2/en active Application Filing
- 2003-06-18 US US10/464,139 patent/US7084160B2/en active Active
- 2003-06-18 JP JP2004515895A patent/JP4477492B2/ja not_active Expired - Fee Related
- 2003-06-18 EP EP03761106A patent/EP1513818B1/en not_active Expired - Lifetime
- 2003-06-18 DE DE60331061T patent/DE60331061D1/de not_active Expired - Lifetime
- 2003-06-18 AU AU2003251559A patent/AU2003251559A1/en not_active Abandoned
- 2003-06-19 AR ARP030102171A patent/AR040272A1/es not_active Application Discontinuation
- 2003-06-20 PE PE2003000622A patent/PE20040581A1/es not_active Application Discontinuation
-
2004
- 2004-11-29 NO NO20045220A patent/NO330043B1/no not_active IP Right Cessation
- 2004-12-15 IS IS7599A patent/IS7599A/is unknown
-
2006
- 2006-02-08 US US11/349,767 patent/US7547711B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003251559A8 (en) | 2004-01-06 |
WO2004001059A2 (en) | 2003-12-31 |
NO330043B1 (no) | 2011-02-07 |
EP1513818A4 (en) | 2006-10-04 |
TW200401638A (en) | 2004-02-01 |
ES2337246T3 (es) | 2010-04-22 |
JP4477492B2 (ja) | 2010-06-09 |
US20060135576A1 (en) | 2006-06-22 |
EP1513818A2 (en) | 2005-03-16 |
US20040077696A1 (en) | 2004-04-22 |
WO2004001059A3 (en) | 2004-03-04 |
DE60331061D1 (de) | 2010-03-11 |
US7084160B2 (en) | 2006-08-01 |
PL374272A1 (en) | 2005-10-03 |
AR040272A1 (es) | 2005-03-23 |
AU2003251559A1 (en) | 2004-01-06 |
EP1513818B1 (en) | 2010-01-20 |
ATE455767T1 (de) | 2010-02-15 |
NO20045220L (no) | 2005-01-19 |
US7547711B2 (en) | 2009-06-16 |
IS7599A (is) | 2004-12-15 |
JP2005533808A (ja) | 2005-11-10 |
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