PA8533301A1 - Derivados de imidazolona para el tratamiento de enfermedades vìricas - Google Patents

Derivados de imidazolona para el tratamiento de enfermedades vìricas

Info

Publication number
PA8533301A1
PA8533301A1 PA20018533301A PA8533301A PA8533301A1 PA 8533301 A1 PA8533301 A1 PA 8533301A1 PA 20018533301 A PA20018533301 A PA 20018533301A PA 8533301 A PA8533301 A PA 8533301A PA 8533301 A1 PA8533301 A1 PA 8533301A1
Authority
PA
Panama
Prior art keywords
víric
diseases
treatment
compounds
formula
Prior art date
Application number
PA20018533301A
Other languages
English (en)
Inventor
Brian William Dymock
Philip Stephen Jones
Martin John Parratt
John Herbert Merrett
Kevin Edward Burdon Parkes
Daryl Simon Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8533301A1 publication Critical patent/PA8533301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCIÓN DESCRIBE NUEVOS DERIVADOS DE IMIDAZOLONA ASÍ COMO LOS ÉTERES O ÉSTERES HIDROLIZABLES DE COMPUESTOS DE FÓRMULA I Y SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, UN PROCESO PARA SU ELABORACIÓN, COMPOSICIONES FARMACÉUTICAS Y EL USO DE TALES COMPUESTOS EN MEDICINA (VER FORMULA I). EN DONDE R1, R2, R3, A Y X SON TAL COMO SE DEFINEN EN LA DESCRIPCIÓN. LOS COMPUESTOS DE FÓRMULA I SON INHIBIDORES DE LA ENZIMA TRANSCRIPTASA REVERSA DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA QUE ESTÁ IMPLICADO EN LA REPLICACIÓN VIRAL. POR CONSIGUIENTES LOS COMPUESTOS DE ESTA INVENCIÓN SE PUEDEN USAR VENTAJOSAMENTE COMO AGENTES TERAPÉUTICAS PARA PROCESOS MEDIADOS POR VIH.
PA20018533301A 2000-11-22 2001-11-21 Derivados de imidazolona para el tratamiento de enfermedades vìricas PA8533301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0028484.4A GB0028484D0 (en) 2000-11-22 2000-11-22 Imidazolone derivatives for the treatment of viral diseases

Publications (1)

Publication Number Publication Date
PA8533301A1 true PA8533301A1 (es) 2002-08-26

Family

ID=9903671

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018533301A PA8533301A1 (es) 2000-11-22 2001-11-21 Derivados de imidazolona para el tratamiento de enfermedades vìricas

Country Status (20)

Country Link
US (1) US6518293B2 (es)
EP (1) EP1341766B1 (es)
JP (1) JP2004514672A (es)
KR (1) KR100528760B1 (es)
CN (1) CN1633417A (es)
AR (1) AR035372A1 (es)
AT (1) ATE307805T1 (es)
AU (2) AU2184202A (es)
BR (1) BR0115476A (es)
CA (1) CA2428461A1 (es)
DE (1) DE60114448T2 (es)
DK (1) DK1341766T3 (es)
ES (1) ES2251529T3 (es)
GB (1) GB0028484D0 (es)
MX (1) MXPA03004454A (es)
PA (1) PA8533301A1 (es)
PE (1) PE20020636A1 (es)
UY (1) UY27035A1 (es)
WO (1) WO2002042279A1 (es)
ZA (1) ZA200303690B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
US20080132549A1 (en) * 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
CA2592909A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
WO2008085008A1 (en) * 2007-01-11 2008-07-17 Mogam Biotechnology Research Institute T-cell inhibiting compounds and their use for the treatment of t-cell-mediated diseases
KR101110120B1 (ko) * 2009-10-28 2012-01-31 주식회사 케이아이테크놀로지 표지판 완충장치

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345936A (en) * 1981-10-05 1982-08-24 Eli Lilly And Company Imidazoles, compositions and herbicidal method
TW235963B (es) 1992-01-16 1994-12-11 Shionogi & Co
EP0627423A4 (en) 1992-01-22 1995-02-15 Nissan Chemical Ind Ltd SUBSTITUTED PYRAZOLE DERIVATIVES AND BACTERICIDES FOR AGRICULTURE AND GARDENING.
GB9222262D0 (en) 1992-10-23 1992-12-09 Merck Sharp & Dohme Therapeutic agents
US5612636A (en) * 1995-01-19 1997-03-18 Texas Instruments Incorporated Short circuit power optimization for CMOS circuits
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US6046331A (en) * 1998-12-17 2000-04-04 Synaptic Pharmaceutical Corporation Imidazolones and their use in treating benign prostatic hyperplasia and other disorders

Also Published As

Publication number Publication date
DE60114448T2 (de) 2006-07-06
AU2184202A (en) 2002-06-03
ATE307805T1 (de) 2005-11-15
EP1341766A1 (en) 2003-09-10
PE20020636A1 (es) 2002-07-18
EP1341766B1 (en) 2005-10-26
AU2002221842B2 (en) 2007-08-23
US6518293B2 (en) 2003-02-11
CA2428461A1 (en) 2002-05-30
ES2251529T3 (es) 2006-05-01
WO2002042279A1 (en) 2002-05-30
UY27035A1 (es) 2002-06-20
AR035372A1 (es) 2004-05-12
GB0028484D0 (en) 2001-01-10
MXPA03004454A (es) 2003-08-19
KR20030060951A (ko) 2003-07-16
KR100528760B1 (ko) 2005-11-15
DE60114448D1 (de) 2005-12-01
US20020107272A1 (en) 2002-08-08
CN1633417A (zh) 2005-06-29
JP2004514672A (ja) 2004-05-20
ZA200303690B (en) 2004-08-13
BR0115476A (pt) 2003-08-19
DK1341766T3 (da) 2006-02-20

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