UY29199A1 - Derivados tiazol, composiciones que los contienen, procedimientos de preparación y aplicaciones - Google Patents

Derivados tiazol, composiciones que los contienen, procedimientos de preparación y aplicaciones

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Publication number
UY29199A1
UY29199A1 UY29199A UY29199A UY29199A1 UY 29199 A1 UY29199 A1 UY 29199A1 UY 29199 A UY29199 A UY 29199A UY 29199 A UY29199 A UY 29199A UY 29199 A1 UY29199 A1 UY 29199A1
Authority
UY
Uruguay
Prior art keywords
compositions
contain
applications
preparation procedures
derivatives
Prior art date
Application number
UY29199A
Other languages
English (en)
Inventor
Malena Bengtsson
Joakim Larsson
Grigorios Nikitidis
Peter Storm
John Peter Bailey
Edward Jolyon Griffen
Jean-Claude Arnould
Thomas Geoffrey Colerick
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY29199A1 publication Critical patent/UY29199A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Diabetes (AREA)
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  • Dermatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
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  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
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Abstract

La invención proporciona derivados tiazol de fórmula (I), o sales farmacéuticamente aceptables de los mismos, en donde el anillo A, R1, R2 y R3 son como se define en la memoria descriptiva; un proceso para su preparación; composiciones farmacéuticas que los contienen; y su uso en terapia, por ejemplo en el tratamiento de una enfermedad mediada por una enzima PI3K y/o una quinasa mTOR.
UY29199A 2004-11-09 2005-11-08 Derivados tiazol, composiciones que los contienen, procedimientos de preparación y aplicaciones UY29199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0402735A SE0402735D0 (sv) 2004-11-09 2004-11-09 Novel compounds

Publications (1)

Publication Number Publication Date
UY29199A1 true UY29199A1 (es) 2006-06-30

Family

ID=33488202

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29199A UY29199A1 (es) 2004-11-09 2005-11-08 Derivados tiazol, composiciones que los contienen, procedimientos de preparación y aplicaciones

Country Status (21)

Country Link
US (1) US7868188B2 (es)
EP (1) EP1841763B1 (es)
JP (1) JP2008519021A (es)
KR (1) KR20070085837A (es)
CN (1) CN101098869A (es)
AR (1) AR052232A1 (es)
AT (1) ATE472546T1 (es)
AU (1) AU2005303566A1 (es)
BR (1) BRPI0517634A (es)
CA (1) CA2585310A1 (es)
DE (1) DE602005022116D1 (es)
ES (1) ES2346333T3 (es)
HK (1) HK1112895A1 (es)
IL (1) IL182726A0 (es)
MX (1) MX2007005546A (es)
NO (1) NO20072259L (es)
SE (1) SE0402735D0 (es)
TW (1) TW200621762A (es)
UY (1) UY29199A1 (es)
WO (1) WO2006051270A1 (es)
ZA (1) ZA200703714B (es)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
CA2607670A1 (en) * 2005-05-10 2006-11-16 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
US7879888B2 (en) 2005-05-24 2011-02-01 Merck Serono Sa Thiazole derivatives and use thereof
ES2389062T3 (es) 2006-01-18 2012-10-22 Amgen, Inc Compuestos de tiazol como inhibidores de proteína cinasa B (PKB)
US20090029997A1 (en) * 2006-01-23 2009-01-29 Laboratoires Serono Sa Thiazole Derivatives and Use Thereof
TW200806641A (en) 2006-01-25 2008-02-01 Synta Pharmaceuticals Corp Substituted aromatic compounds for inflammation and immune-related uses
US8217037B2 (en) * 2006-04-07 2012-07-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
CN101484452A (zh) * 2006-05-03 2009-07-15 阿斯利康(瑞典)有限公司 噻唑衍生物及其作为抗肿瘤药物的用途
EP1887359B1 (en) * 2006-08-03 2008-11-12 Cellzome Ag Methods for the identification of PI3K interacting molecules and for the purification of PI3K
US8268818B2 (en) 2006-09-01 2012-09-18 Vertex Pharmaceuticals Incorporated Inhibitors of C-MET and uses thereof
GB0620059D0 (en) 2006-10-10 2006-11-22 Ucb Sa Therapeutic agents
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