NO20072259L - Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer - Google Patents

Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer

Info

Publication number
NO20072259L
NO20072259L NO20072259A NO20072259A NO20072259L NO 20072259 L NO20072259 L NO 20072259L NO 20072259 A NO20072259 A NO 20072259A NO 20072259 A NO20072259 A NO 20072259A NO 20072259 L NO20072259 L NO 20072259L
Authority
NO
Norway
Prior art keywords
heteroarylthiazoles
inhibitors
therapy
manufacture
processes
Prior art date
Application number
NO20072259A
Other languages
English (en)
Inventor
Joakim Larsson
Peter Storm
Grigorios Nikitidis
John Peter Bailey
Malena Bengtsson
Edward Jolyon Griffen
Jean-Claude Arnould
Thomas Geoffrey Colerick Bird
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20072259L publication Critical patent/NO20072259L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Communicable Diseases (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Oppfinnelsen tilveiebringer tiazolderivater med formel (I) eller farmasøytisk akseptable salter derav, hvori ring A, R1, R2 og R3 er som definert i beskrivelsen; prosesser for deres fremstilling; farmasøytiske preparater inneholdende dem; og anvendelse av dem i terapi, for eksempel ved behandling av sykdom mediert av et PI3K-enzym og/eller en mTOR-kinase. ?? ?? ?? ?? 1
NO20072259A 2004-11-09 2007-04-30 Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer NO20072259L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0402735A SE0402735D0 (sv) 2004-11-09 2004-11-09 Novel compounds
PCT/GB2005/004268 WO2006051270A1 (en) 2004-11-09 2005-11-07 5-heteroaryl thiazoles and their use as p13k inhibitors

Publications (1)

Publication Number Publication Date
NO20072259L true NO20072259L (no) 2007-06-06

Family

ID=33488202

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072259A NO20072259L (no) 2004-11-09 2007-04-30 Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer

Country Status (21)

Country Link
US (1) US7868188B2 (no)
EP (1) EP1841763B1 (no)
JP (1) JP2008519021A (no)
KR (1) KR20070085837A (no)
CN (1) CN101098869A (no)
AR (1) AR052232A1 (no)
AT (1) ATE472546T1 (no)
AU (1) AU2005303566A1 (no)
BR (1) BRPI0517634A (no)
CA (1) CA2585310A1 (no)
DE (1) DE602005022116D1 (no)
ES (1) ES2346333T3 (no)
HK (1) HK1112895A1 (no)
IL (1) IL182726A0 (no)
MX (1) MX2007005546A (no)
NO (1) NO20072259L (no)
SE (1) SE0402735D0 (no)
TW (1) TW200621762A (no)
UY (1) UY29199A1 (no)
WO (1) WO2006051270A1 (no)
ZA (1) ZA200703714B (no)

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TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
EP1891063B1 (en) * 2005-05-10 2012-07-25 Vertex Pharmaceuticals, Inc. Bicyclic derivatives as modulators of ion channels
BRPI0611029A2 (pt) 2005-05-24 2010-08-10 Serono Lab derivados de tiazol e uso dos mesmos
KR20080091369A (ko) 2006-01-18 2008-10-10 암젠 인크 단백질 키나제 ｂ （ｐｋｂ） 억제제로서 티아졸 화합물
JP2009523769A (ja) * 2006-01-23 2009-06-25 ラボラトワール セローノ ソシエテ アノニム チアゾール誘導体及びこれらの使用
CA2640090A1 (en) 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Substituted aromatic compounds for inflammation and immune-related uses
EP2007393B1 (en) * 2006-04-07 2013-08-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
EP2016075A1 (en) * 2006-05-03 2009-01-21 AstraZeneca AB Thiazole derivatives and their use as anti-tumour agents
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