AR055369A1 - Compuestos derivados de xantina, su uso para preparar un medicamento para el tratamiento de una enfermedad mediada por el receptor hm74a, formulaciones y combinacion farmaceuticas que la comprenden y metodo de preparacion de los mismos - Google Patents
Compuestos derivados de xantina, su uso para preparar un medicamento para el tratamiento de una enfermedad mediada por el receptor hm74a, formulaciones y combinacion farmaceuticas que la comprenden y metodo de preparacion de los mismosInfo
- Publication number
- AR055369A1 AR055369A1 ARP060103459A ARP060103459A AR055369A1 AR 055369 A1 AR055369 A1 AR 055369A1 AR P060103459 A ARP060103459 A AR P060103459A AR P060103459 A ARP060103459 A AR P060103459A AR 055369 A1 AR055369 A1 AR 055369A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- preparation
- group selected
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Abstract
Por lo menos una entidad química seleccionada entre compuestos derivados de xantina de formula (1) y sus derivados farmacéuticamente aceptables, en la que: R1 representa -(alquilen)m-X-(alquileno)n-Y; en la que m y n representan el numero de átomos de carbono en la cadena de alquileno; en la que X representa un grupo seleccionado entre heteroarilo y heterociclilo; en la que Y representa un grupo seleccionado entre arilo, heteroarilo y -Oarilo; que pueden estar opcionalmente sustituidos con uno o más grupos independientemente seleccionados entre alquilo C1-6, alquenilo C2-6, alquinilo C2-6, halogeno, -(CH2)qNR5R7, -(CH2)q-(O)p-(CH2)q-N(R5)C(O)OR8, , -(CH2)q-N(R5)C(O)R8, -(CH2)q-(O)p-(CH2)q-C(O)NR5R6, -(CH2)q-N(R5)C(O)NR5R6, -(CH2)q- C(O)N((CH2)mOH)R5, -(CH2)q-N(R5)-S(O)2R8, -CH2-S(O)2NR5R6, -haloalquilo C1-6, OCF3, -OCH(F)2, -OCH2F, -C(O)OR5, -OR5, -R8CN, CN, -SO2R9, -(CH2)nheteroarilo, -(CH2)nheterociclilo, -(CH2)ncicloalquilo, -(CH2)ncicloalquenilo y -(CH2)narilo; R2 representa alquilo C1-6 que puede estar opcionalmente sustituido con uno o más grupos independientemente seleccionados entre cicloalquilo, haloalquilo C1-6, halogeno, -CN y -OR4; R3 representa halogeno; R4 representa un grupo seleccionado entre hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -(CH2)ncicloalquilo, -(CH2)ncicloalquenilo, -(CH2)nheterociclilo, -(CH2)narilo y -(CH2)nheteroarilo; R5 y R6 se seleccionan independientemente entre hidrogeno y alquilo C1-4; R7 representa un grupo seleccionado entre alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -(CH2)tcicloalquilo, -(CH2)cicloalquenilo, -(CH2)theterociclilo, -(CH2)tarilo y -(CH2)theteroarilo; R8 representa alquilo C1-4, R9 representa un grupo seleccionado entre alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -(CH2)ncicloalquilo, -(CH2)ncicloalquenilo, -(CH2)nheterociclilo, -(CH2)narilo, -(CH2)nheteroarilo y CN; m representa un entero seleccionado entre 3 y 4; n representa un entero seleccionado entre 0 y 1; p representa un entero seleccionado entre 0 y 1; q representa un entero seleccionado entre 0, 1 y 2; y t representa un entero seleccionado entre 1 y 2. uso para elaborar un medicamento para tratamiento de una enfermedad en la que contribuye la subactivacion del receptor HM74A o en la que la activacion del receptor será beneficiosa, tal como trastornos del metabolismo de lípidos que incluyen dislipidemia e hiperlipoproteinemia y/o de enfermedades y cuadros inflamatorios. Formulaciones farmacéuticas y combinacion que la comprenden y método de preparacion de dichas entidades químicas. Reivindicacion 18: Un método para la preparacion de por lo menos una entidad química de acuerdo con una cualquiera de las reivindicaciones 1 a 11, a partir de un material de partida apropiado, por ejemplo el o los compuestos de formula (2), en la que PG = grupo protector y R2 es como se definio en la reivindicacion 1, dicho método caracterizado porque comprende: i) alquilacion en N1 de una xantina protegida en N7; ii) alquilacion en N3 de una xantina protegida en N7; iii) halogenacion en C8; y iv) desproteccion de N7; se lleva a cabo en cualquier orden que provea desproteccion después de la alquilacion.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0516464A GB0516464D0 (en) | 2005-08-10 | 2005-08-10 | Novel compounds |
GB0607736A GB0607736D0 (en) | 2006-04-19 | 2006-04-19 | Novel compounds |
GB0614569A GB0614569D0 (en) | 2006-07-21 | 2006-07-21 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
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AR055369A1 true AR055369A1 (es) | 2007-08-22 |
Family
ID=37189397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060103459A AR055369A1 (es) | 2005-08-10 | 2006-08-08 | Compuestos derivados de xantina, su uso para preparar un medicamento para el tratamiento de una enfermedad mediada por el receptor hm74a, formulaciones y combinacion farmaceuticas que la comprenden y metodo de preparacion de los mismos |
Country Status (29)
Country | Link |
---|---|
US (3) | US8143264B2 (es) |
EP (3) | EP1912991B1 (es) |
JP (2) | JP2009504592A (es) |
KR (2) | KR20080034993A (es) |
AR (1) | AR055369A1 (es) |
AT (1) | ATE487719T1 (es) |
AU (2) | AU2006278215A1 (es) |
BR (2) | BRPI0614270A2 (es) |
CA (2) | CA2618963A1 (es) |
CR (2) | CR9749A (es) |
CY (1) | CY1111757T1 (es) |
DE (1) | DE602006018151D1 (es) |
DK (1) | DK1912991T3 (es) |
EA (2) | EA200800564A1 (es) |
ES (1) | ES2401128T3 (es) |
HK (1) | HK1116779A1 (es) |
HR (1) | HRP20100725T1 (es) |
IL (2) | IL189081A0 (es) |
MA (2) | MA29692B1 (es) |
MX (2) | MX2008001931A (es) |
MY (1) | MY142067A (es) |
NO (2) | NO20081212L (es) |
NZ (1) | NZ565494A (es) |
PE (1) | PE20070405A1 (es) |
PL (1) | PL1912991T3 (es) |
PT (1) | PT1912991E (es) |
SI (1) | SI1912991T1 (es) |
TW (1) | TW200800217A (es) |
WO (2) | WO2007017261A1 (es) |
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US7482337B2 (en) * | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
CN1227492C (zh) * | 2003-03-11 | 2005-11-16 | 张跃 | 一种吸收式空调主体 |
GB0319124D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
KR101100601B1 (ko) * | 2004-02-14 | 2011-12-29 | 글락소스미스클라인 엘엘씨 | 신규 화합물 |
WO2006045564A1 (en) | 2004-10-22 | 2006-05-04 | Smithkline Beecham Corporation | Xanthine derivatives with hm74a receptor activity |
WO2006045565A1 (en) * | 2004-10-22 | 2006-05-04 | Smithkline Beecham Corporation | Xanthine derivatives with hm74a receptor activity |
US20090209561A1 (en) * | 2004-10-22 | 2009-08-20 | Richard Jonathan Daniel Hatley | Xanthine Derivatives with HM74A Receptor Activity |
US20080221108A1 (en) * | 2005-02-14 | 2008-09-11 | Richard Hatley | Anthranilic Acid Derivatives As Hm74A Receptor Agonists |
GB0516462D0 (en) * | 2005-08-10 | 2005-09-14 | Smithkline Beecham Corp | Novel compounds |
JP2009504592A (ja) * | 2005-08-10 | 2009-02-05 | スミスクライン・ビーチャム・コーポレイション | 選択的hm74aアゴニストとしてのキサンチン誘導体 |
DE102008009758A1 (de) * | 2008-02-18 | 2009-08-20 | Beiersdorf Ag | Verwendung von 3-(4-Hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-propan-1-on zur verbesserten Hautkonturierung bzw. gegen Cellulite |
AU2009324811B2 (en) | 2008-12-08 | 2013-01-24 | Glaxosmithkline Llc | Novel compounds |
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- 2006-08-08 US US12/063,432 patent/US20100179128A1/en not_active Abandoned
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