UA27108A1 - Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя - Google Patents

Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя

Info

Publication number
UA27108A1
UA27108A1 UA5001540A UA5001540A UA27108A1 UA 27108 A1 UA27108 A1 UA 27108A1 UA 5001540 A UA5001540 A UA 5001540A UA 5001540 A UA5001540 A UA 5001540A UA 27108 A1 UA27108 A1 UA 27108A1
Authority
UA
Ukraine
Prior art keywords
synthesis
acceptable acid
diiodointermediate
compound
pharmaceutically acceptable
Prior art date
Application number
UA5001540A
Other languages
English (en)
Russian (ru)
Inventor
Альберто БАРДЖОТТІ
Маріа ГРАHДІ
Антоніо СУАРАТО
Даніела ФАІАРДІ
Original Assignee
Фармаціа Енд Апджон С.П.А.
Фармациа Енд Апджон С.П.А
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Фармаціа Енд Апджон С.П.А., Фармациа Енд Апджон С.П.А filed Critical Фармаціа Енд Апджон С.П.А.
Publication of UA27108A1 publication Critical patent/UA27108A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Винахід належить до антрациклінових глікозидів загальної формули , де X є лінійним або розгалуженим С1-С6 алкіломабо бензилом, який має (S) або (R) конфігурацію при 2"-вуглецевому атомі, і їх фармацевтично прийнятні кислотно-аддитивні солі. Винахід стосується способів їх отримання і фармацевтичних композицій, що містять ці сполуки.
UA5001540A 1989-12-19 1990-12-18 Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя UA27108A1 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation
PCT/EP1990/002229 WO1991009046A1 (en) 1989-12-19 1990-12-18 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (1)

Publication Number Publication Date
UA27108A1 true UA27108A1 (uk) 2000-02-28

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
UA5001540A UA27108A1 (uk) 1989-12-19 1990-12-18 Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя

Country Status (28)

Country Link
EP (1) EP0434960B1 (uk)
JP (1) JP3300342B2 (uk)
KR (1) KR0183033B1 (uk)
CN (2) CN1024922C (uk)
AT (1) ATE143023T1 (uk)
AU (1) AU636429B2 (uk)
CA (1) CA2046857C (uk)
CZ (1) CZ281949B6 (uk)
DE (1) DE69028610T2 (uk)
DK (1) DK0434960T3 (uk)
ES (1) ES2094136T3 (uk)
FI (1) FI97389C (uk)
GR (1) GR3021557T3 (uk)
HR (1) HRP921226B1 (uk)
HU (2) HU208148B (uk)
IE (1) IE81174B1 (uk)
IL (3) IL96643A (uk)
MY (1) MY119192A (uk)
NO (2) NO175533C (uk)
NZ (1) NZ243695A (uk)
PT (1) PT96226B (uk)
RU (1) RU2100366C1 (uk)
SI (1) SI9012379B (uk)
SK (1) SK621990A3 (uk)
TW (1) TW208019B (uk)
UA (1) UA27108A1 (uk)
WO (1) WO1991009046A1 (uk)
YU (1) YU48136B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
CN100341589C (zh) 2002-05-24 2007-10-10 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
CN1684725A (zh) 2002-09-26 2005-10-19 血管技术国际股份公司 血管周包裹物
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
WO2004082689A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
CN101490047A (zh) * 2006-07-12 2009-07-22 内尔维阿诺医学科学有限公司 晶体盐酸奈莫柔比星
CA2721140C (en) * 2008-04-11 2016-02-09 Tianjin Hemay Bio-Tech Co. Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
EP2646456B1 (en) * 2010-12-02 2015-01-21 Nerviano Medical Sciences S.r.l. Process for the preparation of morpholinyl anthracycline derivatives
RU2666356C2 (ru) 2013-04-29 2018-09-07 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Новые производные морфолинилантрациклина
EP3779446A1 (en) 2013-12-11 2021-02-17 University of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
US20170312290A1 (en) 2014-11-05 2017-11-02 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
FI97389B (fi) 1996-08-30
IL96643A0 (en) 1991-09-16
FI913887A0 (fi) 1991-08-16
HU912994D0 (en) 1992-01-28
DK0434960T3 (da) 1996-10-14
EP0434960A1 (en) 1991-07-03
CZ281949B6 (cs) 1997-04-16
TW208019B (uk) 1993-06-21
CZ621990A3 (en) 1997-01-15
NO940831D0 (no) 1994-03-09
CA2046857C (en) 2001-06-12
MY119192A (en) 2005-04-30
FI97389C (fi) 1996-12-10
AU636429B2 (en) 1993-04-29
YU48136B (sh) 1997-05-28
SK278994B6 (sk) 1998-05-06
WO1991009046A1 (en) 1991-06-27
NO176911C (no) 1995-06-21
CN1053238A (zh) 1991-07-24
JP3300342B2 (ja) 2002-07-08
EP0434960B1 (en) 1996-09-18
JPH04503679A (ja) 1992-07-02
IE904543A1 (en) 1991-06-19
CA2046857A1 (en) 1991-06-20
IL96643A (en) 1995-01-24
SK621990A3 (en) 1998-05-06
ES2094136T3 (es) 1997-01-16
KR920701228A (ko) 1992-08-11
HRP921226B1 (en) 1998-10-31
NO913176L (no) 1991-08-14
NO175533B (no) 1994-07-18
KR0183033B1 (ko) 1999-04-01
HU9200656D0 (en) 1992-05-28
NO176911B (no) 1995-03-13
CN1024922C (zh) 1994-06-08
HU209433B (en) 1994-06-28
AU6919491A (en) 1991-07-18
IL111527A (en) 1998-02-22
IL111527A0 (en) 1995-01-24
ATE143023T1 (de) 1996-10-15
DE69028610D1 (de) 1996-10-24
DE69028610T2 (de) 1997-02-06
YU237990A (sh) 1993-05-28
GR3021557T3 (en) 1997-02-28
HUT60232A (en) 1992-08-28
NO913176D0 (no) 1991-08-14
CN1079215A (zh) 1993-12-08
NO175533C (no) 1994-10-26
PT96226B (pt) 1998-06-30
NZ243695A (en) 1993-06-25
RU2100366C1 (ru) 1997-12-27
PT96226A (pt) 1991-09-30
HRP921226A2 (en) 1995-12-31
SI9012379A (en) 1997-12-31
HU208148B (en) 1993-08-30
HUT59693A (en) 1992-06-29
SI9012379B (sl) 2000-02-29
CN1039708C (zh) 1998-09-09
IE81174B1 (en) 2000-06-14
NO940831L (no) 1991-08-14

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