YU237990A - Morfolinil derivati doksorubicina i postupak za njihovo dobijanje - Google Patents

Morfolinil derivati doksorubicina i postupak za njihovo dobijanje

Info

Publication number
YU237990A
YU237990A YU237990A YU237990A YU237990A YU 237990 A YU237990 A YU 237990A YU 237990 A YU237990 A YU 237990A YU 237990 A YU237990 A YU 237990A YU 237990 A YU237990 A YU 237990A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
morfolinil
docorubicube
procedure
obtaining
Prior art date
Application number
YU237990A
Other languages
English (en)
Other versions
YU48136B (sh
Inventor
Daniela Faiardi
Alberto Bargiotti
Maria Grandi
Antonino Suarato
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Priority to SI9012379A priority Critical patent/SI9012379B/sl
Priority to HRP-2379/90A priority patent/HRP921226B1/xx
Publication of YU237990A publication Critical patent/YU237990A/sh
Publication of YU48136B publication Critical patent/YU48136B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Morfolinilni derivati doksorubicina, ki imajo splošno formulo A: kjer X predstavlja ravno ali razvejeno C1-C6-alkilno skupino ali benzilno skupino -CH2-C6H5, in imajo (S) ali (R) konfiguracijo na C-2 atomu ogljika morfolino obroča, so antitumorska sredstva.
YU237990A 1989-12-19 1990-12-17 Morfolinil derivati doksorubicina i postupak za njihovo dobijanje YU48136B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012379A SI9012379B (sl) 1989-12-19 1990-12-17 Antraciklinski glikozidi in postopek za njihovo pripravo
HRP-2379/90A HRP921226B1 (en) 1989-12-19 1992-11-11 Morpholinyl derivatives of doxorubicin and process for their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (2)

Publication Number Publication Date
YU237990A true YU237990A (sh) 1993-05-28
YU48136B YU48136B (sh) 1997-05-28

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
YU237990A YU48136B (sh) 1989-12-19 1990-12-17 Morfolinil derivati doksorubicina i postupak za njihovo dobijanje

Country Status (28)

Country Link
EP (1) EP0434960B1 (sh)
JP (1) JP3300342B2 (sh)
KR (1) KR0183033B1 (sh)
CN (2) CN1024922C (sh)
AT (1) ATE143023T1 (sh)
AU (1) AU636429B2 (sh)
CA (1) CA2046857C (sh)
CZ (1) CZ281949B6 (sh)
DE (1) DE69028610T2 (sh)
DK (1) DK0434960T3 (sh)
ES (1) ES2094136T3 (sh)
FI (1) FI97389C (sh)
GR (1) GR3021557T3 (sh)
HR (1) HRP921226B1 (sh)
HU (2) HU208148B (sh)
IE (1) IE81174B1 (sh)
IL (3) IL111527A (sh)
MY (1) MY119192A (sh)
NO (2) NO175533C (sh)
NZ (1) NZ243695A (sh)
PT (1) PT96226B (sh)
RU (1) RU2100366C1 (sh)
SI (1) SI9012379B (sh)
SK (1) SK278994B6 (sh)
TW (1) TW208019B (sh)
UA (1) UA27108A1 (sh)
WO (1) WO1991009046A1 (sh)
YU (1) YU48136B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
ES2274823T3 (es) * 1999-12-29 2007-06-01 Immunogen, Inc. Agentes cototoxicos que comprenden doxorrubicinas y daunorrubicinas y su utilizacion terapeutica.
CN100341589C (zh) 2002-05-24 2007-10-10 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
JP2006515186A (ja) 2002-09-26 2006-05-25 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 血管周囲ラップ
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
MXPA05009849A (es) * 2003-03-18 2005-12-06 Pharmacia Italia Spa Terapia combinada que comprende nemorubicina y un inhibidor de la ciclooxigenasa-2.
CA2658146A1 (en) * 2006-07-12 2008-01-17 Nerviano Medical Sciences S.R.L. Crystalline nemorubicin hydrochloride
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
CA2818713C (en) * 2010-12-02 2019-03-26 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
ES2695162T3 (es) 2013-04-29 2019-01-02 Nerviano Medical Sciences Srl Nuevos derivados de morfolinil antraciclina
EP3084445B1 (en) 2013-12-11 2020-10-28 University of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
US20170312290A1 (en) 2014-11-05 2017-11-02 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
AU636429B2 (en) 1993-04-29
ES2094136T3 (es) 1997-01-16
NO940831L (no) 1991-08-14
IL111527A (en) 1998-02-22
IL96643A (en) 1995-01-24
NO175533C (no) 1994-10-26
CZ281949B6 (cs) 1997-04-16
EP0434960A1 (en) 1991-07-03
FI97389B (fi) 1996-08-30
SI9012379B (sl) 2000-02-29
HU209433B (en) 1994-06-28
NO176911C (no) 1995-06-21
JP3300342B2 (ja) 2002-07-08
NO913176L (no) 1991-08-14
HUT60232A (en) 1992-08-28
CN1024922C (zh) 1994-06-08
HRP921226A2 (en) 1995-12-31
JPH04503679A (ja) 1992-07-02
CN1079215A (zh) 1993-12-08
CA2046857A1 (en) 1991-06-20
HRP921226B1 (en) 1998-10-31
CN1039708C (zh) 1998-09-09
GR3021557T3 (en) 1997-02-28
IE81174B1 (en) 2000-06-14
PT96226A (pt) 1991-09-30
DE69028610D1 (de) 1996-10-24
PT96226B (pt) 1998-06-30
SK621990A3 (en) 1998-05-06
TW208019B (sh) 1993-06-21
IL111527A0 (en) 1995-01-24
AU6919491A (en) 1991-07-18
HU912994D0 (en) 1992-01-28
KR0183033B1 (ko) 1999-04-01
WO1991009046A1 (en) 1991-06-27
HU208148B (en) 1993-08-30
KR920701228A (ko) 1992-08-11
YU48136B (sh) 1997-05-28
SK278994B6 (sk) 1998-05-06
NO913176D0 (no) 1991-08-14
NO175533B (no) 1994-07-18
HU9200656D0 (en) 1992-05-28
CA2046857C (en) 2001-06-12
CN1053238A (zh) 1991-07-24
FI913887A0 (fi) 1991-08-16
NZ243695A (en) 1993-06-25
CZ621990A3 (en) 1997-01-15
MY119192A (en) 2005-04-30
UA27108A1 (uk) 2000-02-28
FI97389C (fi) 1996-12-10
SI9012379A (en) 1997-12-31
NO940831D0 (no) 1994-03-09
ATE143023T1 (de) 1996-10-15
NO176911B (no) 1995-03-13
DE69028610T2 (de) 1997-02-06
HUT59693A (en) 1992-06-29
EP0434960B1 (en) 1996-09-18
IE904543A1 (en) 1991-06-19
RU2100366C1 (ru) 1997-12-27
IL96643A0 (en) 1991-09-16
DK0434960T3 (da) 1996-10-14

Similar Documents

Publication Publication Date Title
YU237990A (sh) Morfolinil derivati doksorubicina i postupak za njihovo dobijanje
EP0679641A4 (en) SULFAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING A TRICYCLIC HETEROCYCLE.
ES2068413T3 (es) Derivados de 4-fenilftalazina.
UA21900A (uk) Похідhі глутатіоhу або їх фармацевтичhо прийhятhі солі, які проявляють протизапальhу, протиалергійhу та гепатотропhу активhість, і спосіб їх одержаhhя
MX7260E (es) Procedimiento para preparar derivados de sacarosa 4'halo-substituidos
ES2096572T3 (es) Nuevos derivados de glucosidos de antraciclina y procedimiento para su preparacion.
FI940011A (fi) Mono- ja bis-alkyyliaminoantrasykliinit
MX9101270A (es) Compuesto,preparacion y uso
ES2146661T3 (es) Nuevos derivados de cefem.
ATE72445T1 (de) 4'-epi-4'-aminoanthracycline.
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
ES2061182T3 (es) 2-fluoroneplanocina a y su fabricacion.