IL111527A - 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation - Google Patents

1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation

Info

Publication number
IL111527A
IL111527A IL111527A IL11152790A IL111527A IL 111527 A IL111527 A IL 111527A IL 111527 A IL111527 A IL 111527A IL 11152790 A IL11152790 A IL 11152790A IL 111527 A IL111527 A IL 111527A
Authority
IL
Israel
Prior art keywords
oxa
diiodo
preparation
formula
tlc
Prior art date
Application number
IL111527A
Other languages
English (en)
Hebrew (he)
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL111527A publication Critical patent/IL111527A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/30Compounds having groups
    • C07C43/313Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
IL111527A 1989-12-19 1990-12-12 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation IL111527A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation
IL9664390A IL96643A (en) 1989-12-19 1990-12-12 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it

Publications (1)

Publication Number Publication Date
IL111527A true IL111527A (en) 1998-02-22

Family

ID=26296395

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9664390A IL96643A (en) 1989-12-19 1990-12-12 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it
IL111527A IL111527A (en) 1989-12-19 1990-12-12 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL9664390A IL96643A (en) 1989-12-19 1990-12-12 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Country Status (28)

Country Link
EP (1) EP0434960B1 (sh)
JP (1) JP3300342B2 (sh)
KR (1) KR0183033B1 (sh)
CN (2) CN1024922C (sh)
AT (1) ATE143023T1 (sh)
AU (1) AU636429B2 (sh)
CA (1) CA2046857C (sh)
CZ (1) CZ281949B6 (sh)
DE (1) DE69028610T2 (sh)
DK (1) DK0434960T3 (sh)
ES (1) ES2094136T3 (sh)
FI (1) FI97389C (sh)
GR (1) GR3021557T3 (sh)
HR (1) HRP921226B1 (sh)
HU (2) HU208148B (sh)
IE (1) IE81174B1 (sh)
IL (3) IL96643A (sh)
MY (1) MY119192A (sh)
NO (2) NO175533C (sh)
NZ (1) NZ243695A (sh)
PT (1) PT96226B (sh)
RU (1) RU2100366C1 (sh)
SI (1) SI9012379B (sh)
SK (1) SK278994B6 (sh)
TW (1) TW208019B (sh)
UA (1) UA27108A1 (sh)
WO (1) WO1991009046A1 (sh)
YU (1) YU48136B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
DE60031793T2 (de) * 1999-12-29 2007-08-23 Immunogen Inc., Cambridge Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
CN100341589C (zh) 2002-05-24 2007-10-10 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
CA2633589A1 (en) 2002-09-26 2004-04-08 Angiotech International Ag Perivascular wraps
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
AU2004222527A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
JP2009542765A (ja) * 2006-07-12 2009-12-03 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 結晶性ネモルビシン塩酸塩
CN101555264B (zh) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
ES2533710T3 (es) * 2010-12-02 2015-04-14 Nerviano Medical Sciences S.R.L. Proceso para la preparación de derivados de morfolinil antraciclina
RU2666356C2 (ru) 2013-04-29 2018-09-07 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Новые производные морфолинилантрациклина
WO2015089268A1 (en) 2013-12-11 2015-06-18 University Of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
RU2715902C2 (ru) 2014-11-05 2020-03-04 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Функционализированные производные морфолинилантрациклина
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技(上海)有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
NO913176D0 (no) 1991-08-14
NO175533C (no) 1994-10-26
NO176911B (no) 1995-03-13
CZ621990A3 (en) 1997-01-15
HU209433B (en) 1994-06-28
CN1039708C (zh) 1998-09-09
HUT60232A (en) 1992-08-28
FI913887A0 (fi) 1991-08-16
ES2094136T3 (es) 1997-01-16
WO1991009046A1 (en) 1991-06-27
NO940831L (no) 1991-08-14
SI9012379A (en) 1997-12-31
DE69028610T2 (de) 1997-02-06
PT96226B (pt) 1998-06-30
CN1053238A (zh) 1991-07-24
IL96643A0 (en) 1991-09-16
SK621990A3 (en) 1998-05-06
NO175533B (no) 1994-07-18
NZ243695A (en) 1993-06-25
DE69028610D1 (de) 1996-10-24
KR0183033B1 (ko) 1999-04-01
KR920701228A (ko) 1992-08-11
HUT59693A (en) 1992-06-29
HU208148B (en) 1993-08-30
EP0434960B1 (en) 1996-09-18
ATE143023T1 (de) 1996-10-15
RU2100366C1 (ru) 1997-12-27
JP3300342B2 (ja) 2002-07-08
IE904543A1 (en) 1991-06-19
DK0434960T3 (da) 1996-10-14
NO913176L (no) 1991-08-14
EP0434960A1 (en) 1991-07-03
CN1079215A (zh) 1993-12-08
TW208019B (sh) 1993-06-21
CN1024922C (zh) 1994-06-08
SK278994B6 (sk) 1998-05-06
IL96643A (en) 1995-01-24
FI97389B (fi) 1996-08-30
CZ281949B6 (cs) 1997-04-16
HRP921226A2 (en) 1995-12-31
AU6919491A (en) 1991-07-18
FI97389C (fi) 1996-12-10
NO176911C (no) 1995-06-21
HRP921226B1 (en) 1998-10-31
YU237990A (sh) 1993-05-28
GR3021557T3 (en) 1997-02-28
IE81174B1 (en) 2000-06-14
IL111527A0 (en) 1995-01-24
HU912994D0 (en) 1992-01-28
HU9200656D0 (en) 1992-05-28
YU48136B (sh) 1997-05-28
CA2046857A1 (en) 1991-06-20
JPH04503679A (ja) 1992-07-02
PT96226A (pt) 1991-09-30
MY119192A (en) 2005-04-30
SI9012379B (sl) 2000-02-29
NO940831D0 (no) 1994-03-09
AU636429B2 (en) 1993-04-29
CA2046857C (en) 2001-06-12
UA27108A1 (uk) 2000-02-28

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees