IL111527A - 1,5-דייודו-)s(2-אלקוקסי )או בנזילוקסי(-3-אוקסא-פנטאנים והכנתם - Google Patents

1,5-דייודו-)s(2-אלקוקסי )או בנזילוקסי(-3-אוקסא-פנטאנים והכנתם

Info

Publication number
IL111527A
IL111527A IL111527A IL11152790A IL111527A IL 111527 A IL111527 A IL 111527A IL 111527 A IL111527 A IL 111527A IL 11152790 A IL11152790 A IL 11152790A IL 111527 A IL111527 A IL 111527A
Authority
IL
Israel
Prior art keywords
oxa
diiodo
preparation
formula
tlc
Prior art date
Application number
IL111527A
Other languages
English (en)
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL111527A publication Critical patent/IL111527A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
IL111527A 1989-12-19 1990-12-12 1,5-דייודו-)s(2-אלקוקסי )או בנזילוקסי(-3-אוקסא-פנטאנים והכנתם IL111527A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation
IL9664390A IL96643A (he) 1989-12-19 1990-12-12 3' - דהמינו -'s) - 2" ) - 3( - מתוקסי - " 4 - מורפוליניל( -דוקסורוביצין כירלי, הכנתו ותכשירי רוקחות המכילים אותו

Publications (1)

Publication Number Publication Date
IL111527A true IL111527A (he) 1998-02-22

Family

ID=26296395

Family Applications (3)

Application Number Title Priority Date Filing Date
IL111527A IL111527A (he) 1989-12-19 1990-12-12 1,5-דייודו-)s(2-אלקוקסי )או בנזילוקסי(-3-אוקסא-פנטאנים והכנתם
IL9664390A IL96643A (he) 1989-12-19 1990-12-12 3' - דהמינו -'s) - 2" ) - 3( - מתוקסי - " 4 - מורפוליניל( -דוקסורוביצין כירלי, הכנתו ותכשירי רוקחות המכילים אותו
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL9664390A IL96643A (he) 1989-12-19 1990-12-12 3' - דהמינו -'s) - 2" ) - 3( - מתוקסי - " 4 - מורפוליניל( -דוקסורוביצין כירלי, הכנתו ותכשירי רוקחות המכילים אותו
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Country Status (28)

Country Link
EP (1) EP0434960B1 (he)
JP (1) JP3300342B2 (he)
KR (1) KR0183033B1 (he)
CN (2) CN1024922C (he)
AT (1) ATE143023T1 (he)
AU (1) AU636429B2 (he)
CA (1) CA2046857C (he)
CZ (1) CZ281949B6 (he)
DE (1) DE69028610T2 (he)
DK (1) DK0434960T3 (he)
ES (1) ES2094136T3 (he)
FI (1) FI97389C (he)
GR (1) GR3021557T3 (he)
HR (1) HRP921226B1 (he)
HU (2) HU208148B (he)
IE (1) IE81174B1 (he)
IL (3) IL111527A (he)
MY (1) MY119192A (he)
NO (2) NO175533C (he)
NZ (1) NZ243695A (he)
PT (1) PT96226B (he)
RU (1) RU2100366C1 (he)
SI (1) SI9012379B (he)
SK (1) SK621990A3 (he)
TW (1) TW208019B (he)
UA (1) UA27108A1 (he)
WO (1) WO1991009046A1 (he)
YU (1) YU48136B (he)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
DE60031793T2 (de) * 1999-12-29 2007-08-23 Immunogen Inc., Cambridge Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
AU2003234670B2 (en) 2002-05-24 2010-06-10 Angiotech International Ag Compositions and methods for coating medical implants
MXPA05003183A (es) 2002-09-26 2005-06-08 Angiotech Int Ag Evolturas perivasculares.
EP1594459B1 (en) 2002-12-30 2010-02-17 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2004082689A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
US20100069317A1 (en) * 2006-07-12 2010-03-18 Nerviano Medical Sciences S.R.L. Crystalline nemorubicin hydrochloride
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
CA2818713C (en) * 2010-12-02 2019-03-26 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
WO2014177441A1 (en) 2013-04-29 2014-11-06 Nerviano Medical Sciences S.R.L. New morpholinyl anthracycline derivatives
EP3084445B1 (en) 2013-12-11 2020-10-28 University of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
ES2735375T3 (es) 2014-11-05 2019-12-18 Nerviano Medical Sciences Srl Derivados funcionalizados de morfolinil antraciclina
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
SI9012379B (sl) 2000-02-29
CZ621990A3 (en) 1997-01-15
CA2046857C (en) 2001-06-12
IL96643A (he) 1995-01-24
ES2094136T3 (es) 1997-01-16
CN1079215A (zh) 1993-12-08
IE81174B1 (en) 2000-06-14
DE69028610D1 (de) 1996-10-24
IL111527A0 (en) 1995-01-24
NO913176L (no) 1991-08-14
WO1991009046A1 (en) 1991-06-27
YU48136B (sh) 1997-05-28
NO176911B (no) 1995-03-13
NO913176D0 (no) 1991-08-14
NZ243695A (en) 1993-06-25
DE69028610T2 (de) 1997-02-06
HU912994D0 (en) 1992-01-28
JPH04503679A (ja) 1992-07-02
IL96643A0 (en) 1991-09-16
KR0183033B1 (ko) 1999-04-01
FI97389B (fi) 1996-08-30
NO175533C (no) 1994-10-26
IE904543A1 (en) 1991-06-19
PT96226B (pt) 1998-06-30
ATE143023T1 (de) 1996-10-15
NO176911C (no) 1995-06-21
NO940831L (no) 1991-08-14
CN1053238A (zh) 1991-07-24
PT96226A (pt) 1991-09-30
NO175533B (no) 1994-07-18
CZ281949B6 (cs) 1997-04-16
HUT60232A (en) 1992-08-28
GR3021557T3 (en) 1997-02-28
HRP921226B1 (en) 1998-10-31
KR920701228A (ko) 1992-08-11
CN1024922C (zh) 1994-06-08
YU237990A (sh) 1993-05-28
SK278994B6 (sk) 1998-05-06
CA2046857A1 (en) 1991-06-20
FI913887A0 (fi) 1991-08-16
AU6919491A (en) 1991-07-18
SI9012379A (en) 1997-12-31
DK0434960T3 (da) 1996-10-14
JP3300342B2 (ja) 2002-07-08
HU208148B (en) 1993-08-30
TW208019B (he) 1993-06-21
EP0434960B1 (en) 1996-09-18
HU209433B (en) 1994-06-28
RU2100366C1 (ru) 1997-12-27
HU9200656D0 (en) 1992-05-28
NO940831D0 (no) 1994-03-09
CN1039708C (zh) 1998-09-09
EP0434960A1 (en) 1991-07-03
AU636429B2 (en) 1993-04-29
HUT59693A (en) 1992-06-29
SK621990A3 (en) 1998-05-06
HRP921226A2 (en) 1995-12-31
UA27108A1 (uk) 2000-02-28
MY119192A (en) 2005-04-30
FI97389C (fi) 1996-12-10

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees