LU92545I2 - Ezetimibe en combinaison avec atorvastatine ou leurs sels pharmaceutiquement acceptées, y compris atorvastatine sous forme d'atorvastatine calcique trihydratée - Google Patents

Ezetimibe en combinaison avec atorvastatine ou leurs sels pharmaceutiquement acceptées, y compris atorvastatine sous forme d'atorvastatine calcique trihydratée Download PDF

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Publication number
LU92545I2
LU92545I2 LU92545C LU92545C LU92545I2 LU 92545 I2 LU92545 I2 LU 92545I2 LU 92545 C LU92545 C LU 92545C LU 92545 C LU92545 C LU 92545C LU 92545 I2 LU92545 I2 LU 92545I2
Authority
LU
Luxembourg
Prior art keywords
atorvastatin
aryl
alkyl
substd
ezetimibe
Prior art date
Application number
LU92545C
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English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799377&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU92545(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of LU92545I2 publication Critical patent/LU92545I2/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
LU92545C 1993-09-21 2014-09-12 Ezetimibe en combinaison avec atorvastatine ou leurs sels pharmaceutiquement acceptées, y compris atorvastatine sous forme d'atorvastatine calcique trihydratée LU92545I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10244093A 1993-09-21 1993-09-21
US08/257,593 US5631365A (en) 1993-09-21 1994-06-09 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
PCT/US1994/010099 WO1995008532A1 (fr) 1993-09-21 1994-09-14 Composes d'azetidinone hydroxy-substitues efficaces en tant qu'agents hypocholesterolemiques

Publications (1)

Publication Number Publication Date
LU92545I2 true LU92545I2 (fr) 2015-09-21

Family

ID=26799377

Family Applications (4)

Application Number Title Priority Date Filing Date
LU91050C LU91050I2 (fr) 1993-09-21 2003-12-12 Composes d'azetidinone hydroxy-substitues efficaces en tant qu'agents hypocholesterolemiques.
LU91160C LU91160I2 (fr) 1993-09-21 2005-04-01 Ezetimible ou ses sels acceptés en combinaison avec Simvastatin (Inegy/Vytorin).
LU92544C LU92544I2 (fr) 1993-09-21 2014-09-11 Ezetimibe en combinaison avec rosuvastatine ou luers sels pharmaceutiquement acceptées, y compris rosuvastatine sous forme de sel de zinc
LU92545C LU92545I2 (fr) 1993-09-21 2014-09-12 Ezetimibe en combinaison avec atorvastatine ou leurs sels pharmaceutiquement acceptées, y compris atorvastatine sous forme d'atorvastatine calcique trihydratée

Family Applications Before (3)

Application Number Title Priority Date Filing Date
LU91050C LU91050I2 (fr) 1993-09-21 2003-12-12 Composes d'azetidinone hydroxy-substitues efficaces en tant qu'agents hypocholesterolemiques.
LU91160C LU91160I2 (fr) 1993-09-21 2005-04-01 Ezetimible ou ses sels acceptés en combinaison avec Simvastatin (Inegy/Vytorin).
LU92544C LU92544I2 (fr) 1993-09-21 2014-09-11 Ezetimibe en combinaison avec rosuvastatine ou luers sels pharmaceutiquement acceptées, y compris rosuvastatine sous forme de sel de zinc

Country Status (35)

Country Link
US (5) US5631365A (fr)
EP (1) EP0720599B1 (fr)
JP (1) JP2803908B2 (fr)
KR (1) KR100186853B1 (fr)
CN (1) CN1050830C (fr)
AT (1) ATE180249T1 (fr)
AU (1) AU681445C (fr)
BE (1) BE2014C056I2 (fr)
BR (1) BR1100159A (fr)
CA (1) CA2172149C (fr)
CZ (2) CZ288861B6 (fr)
DE (3) DE122004000026I2 (fr)
DK (1) DK0720599T3 (fr)
ES (1) ES2132432T3 (fr)
FI (1) FI110321B (fr)
FR (1) FR05C0040I2 (fr)
GE (1) GEP20043149B (fr)
GR (1) GR3030312T3 (fr)
HU (1) HU221185B1 (fr)
IL (1) IL110956A (fr)
LU (4) LU91050I2 (fr)
MA (1) MA23332A1 (fr)
MY (1) MY111314A (fr)
NL (2) NL300132I2 (fr)
NO (6) NO305902B1 (fr)
NZ (1) NZ274041A (fr)
PL (1) PL182617B1 (fr)
RU (1) RU2138480C1 (fr)
SG (1) SG46208A1 (fr)
SK (1) SK281067B6 (fr)
TN (1) TNSN94094A1 (fr)
TW (1) TW427974B (fr)
UA (1) UA41948C2 (fr)
WO (1) WO1995008532A1 (fr)
ZA (1) ZA947086B (fr)

Families Citing this family (243)

* Cited by examiner, † Cited by third party
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