ATE369334T1 - Hydroxysubstituierte 2-azetidinone verwendbar als hypocholesterolemische arzneimittel - Google Patents

Hydroxysubstituierte 2-azetidinone verwendbar als hypocholesterolemische arzneimittel

Info

Publication number
ATE369334T1
ATE369334T1 AT05004699T AT05004699T ATE369334T1 AT E369334 T1 ATE369334 T1 AT E369334T1 AT 05004699 T AT05004699 T AT 05004699T AT 05004699 T AT05004699 T AT 05004699T AT E369334 T1 ATE369334 T1 AT E369334T1
Authority
AT
Austria
Prior art keywords
hydroxysubstituted
azetidinone
usable
hypocholesterolemic drugs
hypocholesterolemic
Prior art date
Application number
AT05004699T
Other languages
English (en)
Inventor
Anima Ghosal
Shmuel Zbaida
Swapan K Chowdhury
Robert M Iannucci
Wenqing Feng
Kevin B Alton
James E Patrick
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE369334(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE369334T1 publication Critical patent/ATE369334T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05004699T 2000-12-20 2001-12-17 Hydroxysubstituierte 2-azetidinone verwendbar als hypocholesterolemische arzneimittel ATE369334T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20

Publications (1)

Publication Number Publication Date
ATE369334T1 true ATE369334T1 (de) 2007-08-15

Family

ID=22973953

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01991315T ATE279425T1 (de) 2000-12-20 2001-12-17 Zuckersubstituierte 2-azetidinone verwendbar als hypocholesterdenische arzneimittel
AT05004699T ATE369334T1 (de) 2000-12-20 2001-12-17 Hydroxysubstituierte 2-azetidinone verwendbar als hypocholesterolemische arzneimittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01991315T ATE279425T1 (de) 2000-12-20 2001-12-17 Zuckersubstituierte 2-azetidinone verwendbar als hypocholesterdenische arzneimittel

Country Status (34)

Country Link
US (1) US20020137690A1 (de)
EP (1) EP1347987B1 (de)
JP (2) JP4351842B2 (de)
KR (1) KR100883461B1 (de)
CN (1) CN100475829C (de)
AR (1) AR035611A1 (de)
AT (2) ATE279425T1 (de)
AU (2) AU3104902A (de)
BR (1) BR0116212A (de)
CA (1) CA2432798C (de)
CY (1) CY1106912T1 (de)
CZ (1) CZ302193B6 (de)
DE (2) DE60129863T2 (de)
DK (2) DK1593670T3 (de)
EC (1) ECSP034659A (de)
ES (2) ES2230385T3 (de)
GE (1) GEP20053548B (de)
HU (1) HUP0302269A3 (de)
IL (1) IL155771A0 (de)
MA (1) MA26975A1 (de)
MX (1) MXPA03005671A (de)
MY (1) MY129148A (de)
NO (2) NO326981B1 (de)
NZ (1) NZ525722A (de)
PE (1) PE20020718A1 (de)
PL (1) PL208242B1 (de)
PT (2) PT1347987E (de)
RU (1) RU2297422C2 (de)
SI (2) SI1347987T1 (de)
SK (1) SK286703B6 (de)
TR (1) TR200402758T4 (de)
TW (1) TWI316942B (de)
WO (1) WO2002050090A1 (de)
ZA (1) ZA200303694B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
JP4711600B2 (ja) 2001-01-26 2011-06-29 シェーリング コーポレイション シトステロール血症の処置のための置換アゼチジノン化合物の使用
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
EA006898B1 (ru) 2001-03-28 2006-04-28 Шеринг Корпорейшн Энантиоселективный синтез промежуточных соединений для получения азетидинонов
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
CN100439361C (zh) 2003-03-07 2008-12-03 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2005015434A (ja) 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (de) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Neue hypocholesterolemische Verbindungen
EP1918000A2 (de) 2003-11-05 2008-05-07 Schering Corporation Verbindungen aus lipidverändernden Wirkstoffen und substituierten Azetidinonen und Behandlungen für Gefäßzustände
CA2550215A1 (en) * 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
EP1699760B1 (de) 2003-12-23 2017-05-17 Merck Sharp & Dohme Corp. Antihypercholesterinämische verbindungen
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
EP1807070A1 (de) * 2004-09-29 2007-07-18 Schering Corporation Kombinationen aus substituierten azetidinonen und cb1-antagonisten
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
JP2009529055A (ja) * 2006-03-06 2009-08-13 テバ ファーマシューティカル インダストリーズ リミティド エゼチミベ組成物
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
CN101652377A (zh) * 2007-04-02 2010-02-17 泰拉科斯有限公司 苄基化糖苷衍生物及其用法
EP2379547A1 (de) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidinderivate und verfahren zu deren anwendung
WO2010075069A1 (en) 2008-12-16 2010-07-01 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
CN102388059B (zh) * 2009-02-11 2015-03-04 陶氏益农公司 杀虫组合物
US9212175B2 (en) 2009-03-06 2015-12-15 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
AR004701A1 (es) * 1995-10-31 1999-03-10 Schering Corp 2-azetidinonas substituidas con azucares utiles como agentes hipocolesterolemicos, composicion farmaceutica, proceso para la preparacion dedicha composicion, uso de dichos compuestos para fabricar medicamentos y un equipo.
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
JP4351842B2 (ja) 2009-10-28
PL363237A1 (en) 2004-11-15
SK7702003A3 (en) 2003-10-07
ECSP034659A (es) 2003-07-25
WO2002050090A8 (en) 2004-04-15
TWI316942B (en) 2009-11-11
HUP0302269A3 (en) 2009-08-28
CN100475829C (zh) 2009-04-08
DE60106489T2 (de) 2005-10-13
ES2230385T3 (es) 2005-05-01
TR200402758T4 (tr) 2004-11-22
AU3104902A (en) 2002-07-01
DK1593670T3 (da) 2007-11-05
CZ20031674A3 (cs) 2003-10-15
CY1106912T1 (el) 2012-09-26
ATE279425T1 (de) 2004-10-15
PT1593670E (pt) 2007-11-08
HK1056735A1 (en) 2004-02-27
EP1347987A1 (de) 2003-10-01
PL208242B1 (pl) 2011-04-29
CZ302193B6 (cs) 2010-12-08
HUP0302269A2 (hu) 2003-10-28
AR035611A1 (es) 2004-06-16
RU2003122520A (ru) 2005-02-27
HK1084945A1 (en) 2006-08-11
MY129148A (en) 2007-03-30
SK286703B6 (sk) 2009-03-05
KR20030063414A (ko) 2003-07-28
ZA200303694B (en) 2004-08-13
DE60129863T2 (de) 2008-04-30
SI1593670T1 (sl) 2007-12-31
CA2432798C (en) 2007-02-27
SI1347987T1 (en) 2005-02-28
CA2432798A1 (en) 2002-06-27
NO20032806D0 (no) 2003-06-19
NZ525722A (en) 2004-11-26
DE60129863D1 (de) 2007-09-20
US20020137690A1 (en) 2002-09-26
EP1347987B1 (de) 2004-10-13
CN1483039A (zh) 2004-03-17
RU2297422C2 (ru) 2007-04-20
WO2002050090A1 (en) 2002-06-27
NO20032806L (no) 2003-08-19
PT1347987E (pt) 2005-01-31
NO20083737L (no) 2003-08-19
ES2287826T3 (es) 2007-12-16
JP2004516299A (ja) 2004-06-03
MXPA03005671A (es) 2003-10-06
NO326981B1 (no) 2009-03-30
KR100883461B1 (ko) 2009-02-16
MA26975A1 (fr) 2004-12-20
BR0116212A (pt) 2003-12-30
GEP20053548B (en) 2005-06-27
AU2002231049B2 (en) 2006-07-20
DE60106489D1 (de) 2004-11-18
JP2009132745A (ja) 2009-06-18
DK1347987T3 (da) 2005-01-31
PE20020718A1 (es) 2002-08-09
IL155771A0 (en) 2003-12-23

Similar Documents

Publication Publication Date Title
ATE369334T1 (de) Hydroxysubstituierte 2-azetidinone verwendbar als hypocholesterolemische arzneimittel
NO20003968D0 (no) Farmasøytiske preparater
DE60042164D1 (de) Kompaktes nadelschutzschild
EP1146501A4 (de) Anzeige
DE60018950D1 (de) Gegen zusammendrücken beständige wellschlauchverbindung
DE60235043D1 (de) Kompakater druckwasserkernreaktor
NO20025450L (no) Ny farmasöytisk sammensetning
DK1524266T3 (da) Farmaceutisk sammensætning
NO20032194L (no) Vibrasjonssikt
ATA17922000A (de) Scharnier
DE60142657D1 (de) Scharnier
EP1248673A4 (de) Mischapparat
DE69925989D1 (de) Kompaktpumpe
NO20030917D0 (no) Anvendelse
DE50108606D1 (de) Möbelscharnier
NO20035315D0 (no) Farmasöytiske kombinasjoner
NO20022606L (no) Farmasöytiske kombinasjoner
DE60015788D1 (de) Kompaktes schieberventil
EP1241519A4 (de) Projektionsschirm
DK1331972T3 (da) Farmaceutiske præparater
DE60139257D1 (de) Bifunktionelle antibiotika
DE50114900D1 (de) Möbelscharnier
DE50107617D1 (de) Bedieneinheit
DE60136431D1 (de) Spektrophotometer
DE50113877D1 (de) Sägezahngarnitur

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1593670

Country of ref document: EP