DK1593670T3 - Hydroxysubstituerede 2-azetidinoner, der er anvendelige som hypokolesterolæmiske midler - Google Patents

Hydroxysubstituerede 2-azetidinoner, der er anvendelige som hypokolesterolæmiske midler

Info

Publication number
DK1593670T3
DK1593670T3 DK05004699T DK05004699T DK1593670T3 DK 1593670 T3 DK1593670 T3 DK 1593670T3 DK 05004699 T DK05004699 T DK 05004699T DK 05004699 T DK05004699 T DK 05004699T DK 1593670 T3 DK1593670 T3 DK 1593670T3
Authority
DK
Denmark
Prior art keywords
hydroxy
substituted
hypocholesterolemic agents
azetidinones useful
azetidinones
Prior art date
Application number
DK05004699T
Other languages
English (en)
Inventor
Anima Ghosal
Shmuel Zbaida
Swapan K Chowdhury
Robert M Iannucci
Wenqing Feng
Kevin B Alton
James E Patrick
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1593670(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1593670T3 publication Critical patent/DK1593670T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK05004699T 2000-12-20 2001-12-17 Hydroxysubstituerede 2-azetidinoner, der er anvendelige som hypokolesterolæmiske midler DK1593670T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20
PCT/US2001/049127 WO2002050090A1 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
DK1593670T3 true DK1593670T3 (da) 2007-11-05

Family

ID=22973953

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01991315T DK1347987T3 (da) 2000-12-20 2001-12-17 Sukkersubstituerede 2-azetidinoner, der er anvendelige som hypocholesterolæmiske midler
DK05004699T DK1593670T3 (da) 2000-12-20 2001-12-17 Hydroxysubstituerede 2-azetidinoner, der er anvendelige som hypokolesterolæmiske midler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01991315T DK1347987T3 (da) 2000-12-20 2001-12-17 Sukkersubstituerede 2-azetidinoner, der er anvendelige som hypocholesterolæmiske midler

Country Status (35)

Country Link
US (1) US20020137690A1 (da)
EP (1) EP1347987B1 (da)
JP (2) JP4351842B2 (da)
KR (1) KR100883461B1 (da)
CN (1) CN100475829C (da)
AR (1) AR035611A1 (da)
AT (2) ATE369334T1 (da)
AU (2) AU3104902A (da)
BR (1) BR0116212A (da)
CA (1) CA2432798C (da)
CY (1) CY1106912T1 (da)
CZ (1) CZ302193B6 (da)
DE (2) DE60129863T2 (da)
DK (2) DK1347987T3 (da)
EC (1) ECSP034659A (da)
ES (2) ES2230385T3 (da)
GE (1) GEP20053548B (da)
HK (2) HK1056735A1 (da)
HU (1) HUP0302269A3 (da)
IL (1) IL155771A0 (da)
MA (1) MA26975A1 (da)
MX (1) MXPA03005671A (da)
MY (1) MY129148A (da)
NO (2) NO326981B1 (da)
NZ (1) NZ525722A (da)
PE (1) PE20020718A1 (da)
PL (1) PL208242B1 (da)
PT (2) PT1593670E (da)
RU (1) RU2297422C2 (da)
SI (2) SI1593670T1 (da)
SK (1) SK286703B6 (da)
TR (1) TR200402758T4 (da)
TW (1) TWI316942B (da)
WO (1) WO2002050090A1 (da)
ZA (1) ZA200303694B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50386B (sr) 2001-03-28 2009-12-31 Schering Corporation, Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP2005015434A (ja) 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
WO2005061452A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
EP1699760B1 (en) 2003-12-23 2017-05-17 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
EP1807070A1 (en) * 2004-09-29 2007-07-18 Schering Corporation Combinations of substituted azetidinones and cb1 antagonists
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008136765A (ru) * 2006-03-06 2010-04-20 Тева Фармасьютикл Индастриес Лтд. (Il) Композиции эзетимиба
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
US7838498B2 (en) * 2007-04-02 2010-11-23 Theracos, Inc. Benzylic glycoside derivatives and methods of use
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
WO2010093752A1 (en) * 2009-02-11 2010-08-19 Dow Agrosciences Llc Pesticidal compositions
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
WO1997016455A1 (en) * 1995-10-31 1997-05-09 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
WO2002050090A8 (en) 2004-04-15
ES2287826T3 (es) 2007-12-16
DE60106489D1 (de) 2004-11-18
SI1347987T1 (en) 2005-02-28
AU2002231049B2 (en) 2006-07-20
ATE369334T1 (de) 2007-08-15
NO20032806D0 (no) 2003-06-19
KR20030063414A (ko) 2003-07-28
SK286703B6 (sk) 2009-03-05
DK1347987T3 (da) 2005-01-31
JP2004516299A (ja) 2004-06-03
PL208242B1 (pl) 2011-04-29
CN100475829C (zh) 2009-04-08
CA2432798C (en) 2007-02-27
HUP0302269A2 (hu) 2003-10-28
ATE279425T1 (de) 2004-10-15
PL363237A1 (en) 2004-11-15
CZ20031674A3 (cs) 2003-10-15
NO20083737L (no) 2003-08-19
DE60129863D1 (de) 2007-09-20
NO326981B1 (no) 2009-03-30
RU2003122520A (ru) 2005-02-27
JP2009132745A (ja) 2009-06-18
NO20032806L (no) 2003-08-19
CA2432798A1 (en) 2002-06-27
SI1593670T1 (sl) 2007-12-31
US20020137690A1 (en) 2002-09-26
HK1084945A1 (en) 2006-08-11
NZ525722A (en) 2004-11-26
CN1483039A (zh) 2004-03-17
GEP20053548B (en) 2005-06-27
ECSP034659A (es) 2003-07-25
BR0116212A (pt) 2003-12-30
IL155771A0 (en) 2003-12-23
TWI316942B (en) 2009-11-11
CZ302193B6 (cs) 2010-12-08
PT1347987E (pt) 2005-01-31
AU3104902A (en) 2002-07-01
EP1347987B1 (en) 2004-10-13
RU2297422C2 (ru) 2007-04-20
WO2002050090A1 (en) 2002-06-27
TR200402758T4 (tr) 2004-11-22
JP4351842B2 (ja) 2009-10-28
MY129148A (en) 2007-03-30
MA26975A1 (fr) 2004-12-20
EP1347987A1 (en) 2003-10-01
KR100883461B1 (ko) 2009-02-16
ZA200303694B (en) 2004-08-13
PT1593670E (pt) 2007-11-08
AR035611A1 (es) 2004-06-16
MXPA03005671A (es) 2003-10-06
SK7702003A3 (en) 2003-10-07
PE20020718A1 (es) 2002-08-09
HK1056735A1 (en) 2004-02-27
HUP0302269A3 (en) 2009-08-28
DE60106489T2 (de) 2005-10-13
ES2230385T3 (es) 2005-05-01
CY1106912T1 (el) 2012-09-26
DE60129863T2 (de) 2008-04-30

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