HK1056735A1 - Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents. - Google Patents

Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents.

Info

Publication number
HK1056735A1
HK1056735A1 HK03109136A HK03109136A HK1056735A1 HK 1056735 A1 HK1056735 A1 HK 1056735A1 HK 03109136 A HK03109136 A HK 03109136A HK 03109136 A HK03109136 A HK 03109136A HK 1056735 A1 HK1056735 A1 HK 1056735A1
Authority
HK
Hong Kong
Prior art keywords
sugar
substituted
cholesterol
hypocholesterolemic agents
azetidinones useful
Prior art date
Application number
HK03109136A
Other languages
English (en)
Inventor
Anima Ghosal
Shmuel Zbaida
Swapan K Chowdhury
Robert M Iannucci
Wenqing Feng
Kevin B Alton
James E Patrick
Harry R Davis
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1056735(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1056735A1 publication Critical patent/HK1056735A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK03109136A 2000-12-20 2003-12-15 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents. HK1056735A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20
PCT/US2001/049127 WO2002050090A1 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
HK1056735A1 true HK1056735A1 (en) 2004-02-27

Family

ID=22973953

Family Applications (2)

Application Number Title Priority Date Filing Date
HK03109136A HK1056735A1 (en) 2000-12-20 2003-12-15 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents.
HK06104984A HK1084945A1 (en) 2000-12-20 2005-07-14 Hydroxy-substituted 2-azetidinones useful as hypocholesterolemic agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK06104984A HK1084945A1 (en) 2000-12-20 2005-07-14 Hydroxy-substituted 2-azetidinones useful as hypocholesterolemic agents

Country Status (35)

Country Link
US (1) US20020137690A1 (da)
EP (1) EP1347987B1 (da)
JP (2) JP4351842B2 (da)
KR (1) KR100883461B1 (da)
CN (1) CN100475829C (da)
AR (1) AR035611A1 (da)
AT (2) ATE369334T1 (da)
AU (2) AU3104902A (da)
BR (1) BR0116212A (da)
CA (1) CA2432798C (da)
CY (1) CY1106912T1 (da)
CZ (1) CZ302193B6 (da)
DE (2) DE60129863T2 (da)
DK (2) DK1347987T3 (da)
EC (1) ECSP034659A (da)
ES (2) ES2230385T3 (da)
GE (1) GEP20053548B (da)
HK (2) HK1056735A1 (da)
HU (1) HUP0302269A3 (da)
IL (1) IL155771A0 (da)
MA (1) MA26975A1 (da)
MX (1) MXPA03005671A (da)
MY (1) MY129148A (da)
NO (2) NO326981B1 (da)
NZ (1) NZ525722A (da)
PE (1) PE20020718A1 (da)
PL (1) PL208242B1 (da)
PT (2) PT1593670E (da)
RU (1) RU2297422C2 (da)
SI (2) SI1593670T1 (da)
SK (1) SK286703B6 (da)
TR (1) TR200402758T4 (da)
TW (1) TWI316942B (da)
WO (1) WO2002050090A1 (da)
ZA (1) ZA200303694B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50386B (sr) 2001-03-28 2009-12-31 Schering Corporation, Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP2005015434A (ja) 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
WO2005061452A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
EP1699760B1 (en) 2003-12-23 2017-05-17 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
EP1807070A1 (en) * 2004-09-29 2007-07-18 Schering Corporation Combinations of substituted azetidinones and cb1 antagonists
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008136765A (ru) * 2006-03-06 2010-04-20 Тева Фармасьютикл Индастриес Лтд. (Il) Композиции эзетимиба
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
US7838498B2 (en) * 2007-04-02 2010-11-23 Theracos, Inc. Benzylic glycoside derivatives and methods of use
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
WO2010093752A1 (en) * 2009-02-11 2010-08-19 Dow Agrosciences Llc Pesticidal compositions
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
WO1997016455A1 (en) * 1995-10-31 1997-05-09 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
WO2002050090A8 (en) 2004-04-15
ES2287826T3 (es) 2007-12-16
DE60106489D1 (de) 2004-11-18
SI1347987T1 (en) 2005-02-28
AU2002231049B2 (en) 2006-07-20
ATE369334T1 (de) 2007-08-15
NO20032806D0 (no) 2003-06-19
KR20030063414A (ko) 2003-07-28
SK286703B6 (sk) 2009-03-05
DK1347987T3 (da) 2005-01-31
JP2004516299A (ja) 2004-06-03
PL208242B1 (pl) 2011-04-29
CN100475829C (zh) 2009-04-08
CA2432798C (en) 2007-02-27
HUP0302269A2 (hu) 2003-10-28
ATE279425T1 (de) 2004-10-15
PL363237A1 (en) 2004-11-15
CZ20031674A3 (cs) 2003-10-15
NO20083737L (no) 2003-08-19
DE60129863D1 (de) 2007-09-20
NO326981B1 (no) 2009-03-30
RU2003122520A (ru) 2005-02-27
JP2009132745A (ja) 2009-06-18
NO20032806L (no) 2003-08-19
CA2432798A1 (en) 2002-06-27
SI1593670T1 (sl) 2007-12-31
US20020137690A1 (en) 2002-09-26
HK1084945A1 (en) 2006-08-11
NZ525722A (en) 2004-11-26
CN1483039A (zh) 2004-03-17
GEP20053548B (en) 2005-06-27
ECSP034659A (es) 2003-07-25
BR0116212A (pt) 2003-12-30
IL155771A0 (en) 2003-12-23
TWI316942B (en) 2009-11-11
CZ302193B6 (cs) 2010-12-08
PT1347987E (pt) 2005-01-31
AU3104902A (en) 2002-07-01
DK1593670T3 (da) 2007-11-05
EP1347987B1 (en) 2004-10-13
RU2297422C2 (ru) 2007-04-20
WO2002050090A1 (en) 2002-06-27
TR200402758T4 (tr) 2004-11-22
JP4351842B2 (ja) 2009-10-28
MY129148A (en) 2007-03-30
MA26975A1 (fr) 2004-12-20
EP1347987A1 (en) 2003-10-01
KR100883461B1 (ko) 2009-02-16
ZA200303694B (en) 2004-08-13
PT1593670E (pt) 2007-11-08
AR035611A1 (es) 2004-06-16
MXPA03005671A (es) 2003-10-06
SK7702003A3 (en) 2003-10-07
PE20020718A1 (es) 2002-08-09
HUP0302269A3 (en) 2009-08-28
DE60106489T2 (de) 2005-10-13
ES2230385T3 (es) 2005-05-01
CY1106912T1 (el) 2012-09-26
DE60129863T2 (de) 2008-04-30

Similar Documents

Publication Publication Date Title
HK1056735A1 (en) Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents.
MY114803A (en) Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
TWI320406B (en) Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
CA2407100A1 (en) 1-aroyl-piperidinyl benzamidines
MXPA04002167A (es) Inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes.
PH12012501351A1 (en) Synthesis of eporthilones, intermediates thereto, analogues and uses thereof
HUP0303929A2 (hu) Szubsztituált azetidinon vegyületeket tartalmazó gyógyszerkészítmények alkalmazása szitoszterinémia kezelésére
HUP0303876A3 (en) Preparation of pharmaceutical compositions for treatment of type 2 diabetes using piperidine or tiazolidine, inhibitors of dipeptidyl peptidase iv
MXPA05009501A (es) Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
HRP20090159T1 (en) Use of glucosidase inhibitors for therapy of mucovisidosis
HK1155146A1 (zh) 作為藥物活性劑的茚衍生物
HK1085675A1 (en) Anticancer compounds
HK1100559A1 (en) N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b
WO2005046797A3 (en) Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
MXPA05009503A (es) Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
RS108504A (en) Ring-substituted diphenyl azetidinones, method for the production thereof,medicaments containing said compounds, and use thereof
JO2409B1 (en) Second-phenyl carboxy amides are useful as lipid-lowering agents
MY136267A (en) Lipid lowering biphenylcarboxamides
IL159412A0 (en) A synergistic pharmaceutical combination for the prevention or treatment of diabetes
MXPA02010320A (es) Un derivado piridin-1-oxido, y procedimiento para su transformacion en compuestos farmaceuticamente efectivos.
MXPA05009502A (es) Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
AU2002339158A1 (en) 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
HK1061355A1 (en) Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence
AU2002212241A1 (en) Method for producing chiral compounds
WO2003090737A3 (en) Methods and compositions for treatment of cancer pain

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171217