TWI701048B - 新穎脂肪酸及其於共軛至生物分子之用途 - Google Patents

新穎脂肪酸及其於共軛至生物分子之用途 Download PDF

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TWI701048B
TWI701048B TW104120074A TW104120074A TWI701048B TW I701048 B TWI701048 B TW I701048B TW 104120074 A TW104120074 A TW 104120074A TW 104120074 A TW104120074 A TW 104120074A TW I701048 B TWI701048 B TW I701048B
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conjugate
hgdf15
acid
disease
fatty acid
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TW201613653A (en
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大衛 溫英傑 伯尼斯
山田健
去克溫杜 伊比邦久
阿洛克許 都塔羅伊
路易斯 克萊爾 可曼
亞立山卓 馬歇爾 布魯斯
愛咪 瑞察德森 優瑟拉
佛瑞德利克 查克利
強 元
樓長剛
艾倫 肯特
愛薇洛普 博斯
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瑞士商諾華公司
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TW104120074A 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途 TWI701048B (zh)

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Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US62/015,862 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US62/082,327 2014-11-20
US201562107016P 2015-01-23 2015-01-23
US62/107,016 2015-01-23

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TW110136772A TWI792596B (zh) 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途
TW104120074A TWI701048B (zh) 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途
TW109123095A TWI750725B (zh) 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途

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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
EP2694092B1 (en) 2011-04-08 2017-01-04 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
WO2015017710A1 (en) 2013-07-31 2015-02-05 Amgen Inc. Growth differentiation factor 15 (gdf-15) constructs
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
JP2017537926A (ja) 2014-12-04 2017-12-21 ノバルティス アーゲー Klotho変種ポリペプチドを使用する方法および組成物
BR112017014194A2 (pt) 2015-01-23 2018-01-09 Novartis Ag conjugados de ácido graxo de apelina sintéticos com meia-vida melhorada
JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts 十分に安定化された非対称sirna
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
JP6946304B2 (ja) * 2015-12-22 2021-10-06 ノバルティス アーゲー 増殖分化因子15(gdf−15)を使用して代謝障害を処置するまたは軽快させる方法
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