TW303362B - - Google Patents

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Publication number
TW303362B
TW303362B TW084113098A TW84113098A TW303362B TW 303362 B TW303362 B TW 303362B TW 084113098 A TW084113098 A TW 084113098A TW 84113098 A TW84113098 A TW 84113098A TW 303362 B TW303362 B TW 303362B
Authority
TW
Taiwan
Prior art keywords
compound
tetrahydro
patent application
alkyl group
hydrogen
Prior art date
Application number
TW084113098A
Other languages
English (en)
Chinese (zh)
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of TW303362B publication Critical patent/TW303362B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW084113098A 1994-12-14 1995-12-08 TW303362B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
TW303362B true TW303362B (cg-RX-API-DMAC7.html) 1997-04-21

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084113098A TW303362B (cg-RX-API-DMAC7.html) 1994-12-14 1995-12-08

Country Status (26)

Country Link
US (1) US5658938A (cg-RX-API-DMAC7.html)
EP (1) EP0717037A1 (cg-RX-API-DMAC7.html)
JP (1) JPH08208622A (cg-RX-API-DMAC7.html)
KR (1) KR960022474A (cg-RX-API-DMAC7.html)
CN (1) CN1054376C (cg-RX-API-DMAC7.html)
AR (1) AR002257A1 (cg-RX-API-DMAC7.html)
AU (1) AU693614B2 (cg-RX-API-DMAC7.html)
BG (1) BG63043B1 (cg-RX-API-DMAC7.html)
BR (1) BR9505815A (cg-RX-API-DMAC7.html)
CA (1) CA2165133A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ327195A3 (cg-RX-API-DMAC7.html)
EE (1) EE9500064A (cg-RX-API-DMAC7.html)
FI (1) FI955927A7 (cg-RX-API-DMAC7.html)
GB (1) GB9425211D0 (cg-RX-API-DMAC7.html)
HU (1) HUT73980A (cg-RX-API-DMAC7.html)
IL (1) IL116325A (cg-RX-API-DMAC7.html)
IS (1) IS4311A (cg-RX-API-DMAC7.html)
MX (1) MX9505063A (cg-RX-API-DMAC7.html)
NO (1) NO305316B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ280646A (cg-RX-API-DMAC7.html)
PL (1) PL311736A1 (cg-RX-API-DMAC7.html)
RO (1) RO113346B1 (cg-RX-API-DMAC7.html)
RU (1) RU2156239C2 (cg-RX-API-DMAC7.html)
SK (1) SK155095A3 (cg-RX-API-DMAC7.html)
TW (1) TW303362B (cg-RX-API-DMAC7.html)
ZA (1) ZA9510554B (cg-RX-API-DMAC7.html)

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ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
CZ20023674A3 (cs) 2000-05-08 2003-09-17 Orion Corporation Nové polycyklické indanylimidazolové sloučeniny s alfa2 adrenergní aktivitou
TW200306783A (en) * 2002-04-29 2003-12-01 Fmc Corp Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
BRPI0707258A2 (pt) * 2005-01-27 2011-04-26 Hoffmann La Roche uso de 2-imidazóis para o tratamento de distúrbios de cns
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RU2009112496A (ru) * 2006-10-19 2010-11-27 Ф. Хоффманн-Ля Рош Аг (Ch) Аминометил-4-имидазолы
KR101176700B1 (ko) * 2006-11-02 2012-08-23 에프. 호프만-라 로슈 아게 미량 아민 결합된 수용체의 조절자로서 치환된 2-이미다졸
CN101535298A (zh) * 2006-11-16 2009-09-16 弗·哈夫曼-拉罗切有限公司 取代的4-咪唑类化合物
WO2008071574A1 (en) * 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
UA98951C2 (ru) 2007-02-02 2012-07-10 Ф. Хоффманн-Ля Рош Аг 2-аминооксазолины и лекарственное средство, которое их содержит
US8501747B2 (en) * 2007-02-13 2013-08-06 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
EP2142538B1 (en) * 2007-02-13 2011-10-26 Schering Corporation Derivatives and analogs of chroman as functionally selective alpha2c adrenoreceptor agonists
MX2009008776A (es) * 2007-02-13 2009-08-25 Schering Corp Agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos.
KR101335845B1 (ko) * 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
CA2691082A1 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
CN101687811A (zh) * 2007-07-03 2010-03-31 弗·哈夫曼-拉罗切有限公司 4-咪唑啉类及其作为抗抑郁剂的应用
EP2183216A1 (en) * 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
WO2009016088A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
JP5341084B2 (ja) * 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP2257546B1 (en) 2008-02-21 2012-08-15 Merck Sharp & Dohme Corp. Functionally selective alpha2c adrenoreceptor agonists
AU2009273324A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
WO2010042473A1 (en) 2008-10-07 2010-04-15 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
JP5872069B2 (ja) 2012-01-12 2016-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 微量アミン関連受容体（ｔａａｒ）としての複素環誘導体
JP2015531782A (ja) 2012-09-14 2015-11-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ うつ病、糖尿病及びパーキンソン病のような幾つかの障害の処置において使用するためのｔａａｒ調節薬としてのピラゾールカルボキサミド誘導体
BR112015001771B1 (pt) 2012-09-17 2022-08-16 F. Hoffmann-La Roche Ag Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
CN107001259B (zh) 2014-08-27 2019-12-06 豪夫迈·罗氏有限公司 作为taar配体的取代的氮杂环丁烷衍生物
EP3186250B1 (en) 2014-08-27 2018-04-18 F.Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
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CA3013696C (en) 2016-03-17 2024-04-16 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
KR960022474A (ko) 1996-07-18
NZ280646A (en) 1996-08-27
NO955034L (no) 1996-06-17
RU2156239C2 (ru) 2000-09-20
IS4311A (is) 1996-06-15
FI955927A0 (fi) 1995-12-11
CZ327195A3 (en) 1996-07-17
BG63043B1 (bg) 2001-02-28
NO305316B1 (no) 1999-05-10
CA2165133A1 (en) 1996-06-15
IL116325A0 (en) 1996-03-31
AU4036895A (en) 1996-06-20
GB9425211D0 (en) 1995-02-15
PL311736A1 (en) 1996-06-24
FI955927L (fi) 1996-06-15
MX9505063A (es) 1997-01-31
RO113346B1 (ro) 1998-06-30
US5658938A (en) 1997-08-19
AR002257A1 (es) 1998-03-11
AU693614B2 (en) 1998-07-02
EP0717037A1 (fr) 1996-06-19
BG100208A (bg) 1996-07-31
CN1054376C (zh) 2000-07-12
HUT73980A (en) 1996-10-28
NO955034D0 (no) 1995-12-12
JPH08208622A (ja) 1996-08-13
FI955927A7 (fi) 1996-06-15
BR9505815A (pt) 1998-01-06
HU9503549D0 (en) 1996-02-28
CN1133837A (zh) 1996-10-23
SK155095A3 (en) 1997-02-05
IL116325A (en) 1999-10-28
EE9500064A (et) 1996-06-17
ZA9510554B (en) 1996-06-13

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