NO305316B1 - Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disse - Google Patents
Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disseInfo
- Publication number
- NO305316B1 NO305316B1 NO955034A NO955034A NO305316B1 NO 305316 B1 NO305316 B1 NO 305316B1 NO 955034 A NO955034 A NO 955034A NO 955034 A NO955034 A NO 955034A NO 305316 B1 NO305316 B1 NO 305316B1
- Authority
- NO
- Norway
- Prior art keywords
- imidazoles
- pharmaceutical preparations
- preparations containing
- new substituted
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Publications (3)
Publication Number | Publication Date |
---|---|
NO955034D0 NO955034D0 (no) | 1995-12-12 |
NO955034L NO955034L (no) | 1996-06-17 |
NO305316B1 true NO305316B1 (no) | 1999-05-10 |
Family
ID=10765918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO955034A NO305316B1 (no) | 1994-12-14 | 1995-12-12 | Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disse |
Country Status (26)
Country | Link |
---|---|
US (1) | US5658938A (no) |
EP (1) | EP0717037A1 (no) |
JP (1) | JPH08208622A (no) |
KR (1) | KR960022474A (no) |
CN (1) | CN1054376C (no) |
AR (1) | AR002257A1 (no) |
AU (1) | AU693614B2 (no) |
BG (1) | BG63043B1 (no) |
BR (1) | BR9505815A (no) |
CA (1) | CA2165133A1 (no) |
CZ (1) | CZ327195A3 (no) |
EE (1) | EE9500064A (no) |
FI (1) | FI955927A (no) |
GB (1) | GB9425211D0 (no) |
HU (1) | HUT73980A (no) |
IL (1) | IL116325A (no) |
IS (1) | IS4311A (no) |
MX (1) | MX9505063A (no) |
NO (1) | NO305316B1 (no) |
NZ (1) | NZ280646A (no) |
PL (1) | PL311736A1 (no) |
RO (1) | RO113346B1 (no) |
RU (1) | RU2156239C2 (no) |
SK (1) | SK155095A3 (no) |
TW (1) | TW303362B (no) |
ZA (1) | ZA9510554B (no) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
ZA981080B (en) | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
CZ20023674A3 (cs) | 2000-05-08 | 2003-09-17 | Orion Corporation | Nové polycyklické indanylimidazolové sloučeniny s alfa2 adrenergní aktivitou |
TW200930291A (en) * | 2002-04-29 | 2009-07-16 | Bayer Cropscience Ag | Pesticidal heterocycles |
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
WO2007085558A1 (en) * | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of cns disorders |
MX2009003887A (es) * | 2006-10-19 | 2009-04-22 | Hoffmann La Roche | Aminometil-2-imidazoles con afinidad con los receptores asociados a trazas de amina. |
CN101528710B (zh) * | 2006-10-19 | 2012-11-07 | 弗·哈夫曼-拉罗切有限公司 | 氨基甲基-4-咪唑类 |
WO2008052907A1 (en) * | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
JP2010510184A (ja) * | 2006-11-16 | 2010-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換4−イミダゾール類 |
CN101557810B (zh) * | 2006-12-13 | 2012-11-21 | 弗·哈夫曼-拉罗切有限公司 | 作为痕量胺相关受体(taar)的配体的新的2-咪唑类 |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
KR101174191B1 (ko) * | 2007-02-02 | 2012-08-14 | 에프. 호프만-라 로슈 아게 | 중추 신경계 장애의 치료용 taar1 리간드로서 2-아미노옥사졸린 |
MX2009008777A (es) * | 2007-02-13 | 2009-08-25 | Schering Corp | Derivados y analogos de cromano como agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos. |
CA2678036A1 (en) * | 2007-02-13 | 2008-08-21 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
CL2008000431A1 (es) * | 2007-02-13 | 2008-08-18 | Schering Corp | Compuestos derivados de biciclos o heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones relacionadas con los a2c adrenegicos, tales como congestion relacionada con rinitis, polipos o re |
WO2008098857A1 (en) * | 2007-02-15 | 2008-08-21 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
EP2173720A2 (en) | 2007-07-02 | 2010-04-14 | F. Hoffmann-Roche AG | 2-imidazolines having a good affinity to the trace amine associated receptors (taars) |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
KR101133862B1 (ko) * | 2007-07-27 | 2012-04-06 | 에프. 호프만-라 로슈 아게 | Taar 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민 |
CN101765425A (zh) * | 2007-08-02 | 2010-06-30 | 弗·哈夫曼-拉罗切有限公司 | 苯甲酰胺衍生物用于治疗cns障碍的用途 |
WO2009019149A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
EP2257546B1 (en) | 2008-02-21 | 2012-08-15 | Merck Sharp & Dohme Corp. | Functionally selective alpha2c adrenoreceptor agonists |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
CA2728480A1 (en) * | 2008-07-24 | 2010-01-28 | F. Hoffmann-La Roche Ag | 4,5-dihydro-oxazol-2-yl derivatives |
WO2010017120A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
EP2356106A1 (en) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
MX354815B (es) | 2012-01-12 | 2018-03-22 | Hoffmann La Roche | Derivados heterociclicos como receptores asociados con las aminas traza (taars). |
NZ705154A (en) | 2012-09-14 | 2018-03-23 | Hoffmann La Roche | Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson’s disease |
BR112015001771B1 (pt) * | 2012-09-17 | 2022-08-16 | F. Hoffmann-La Roche Ag | Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende |
WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
JP6539724B2 (ja) | 2014-08-27 | 2019-07-03 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Taarリガンドとしての置換アゼチジン誘導体 |
CA2953040A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
BR112018068688B1 (pt) * | 2016-03-17 | 2023-02-14 | Fmc Corporation | Processo para converter enantiômero s em sua forma racêmica, composto e uso do mesmo |
WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-11 FI FI955927A patent/FI955927A/fi unknown
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ327195A3 (en) | 1996-07-17 |
ZA9510554B (en) | 1996-06-13 |
RO113346B1 (ro) | 1998-06-30 |
BR9505815A (pt) | 1998-01-06 |
JPH08208622A (ja) | 1996-08-13 |
BG100208A (bg) | 1996-07-31 |
HU9503549D0 (en) | 1996-02-28 |
CN1054376C (zh) | 2000-07-12 |
IS4311A (is) | 1996-06-15 |
IL116325A0 (en) | 1996-03-31 |
NO955034L (no) | 1996-06-17 |
KR960022474A (ko) | 1996-07-18 |
US5658938A (en) | 1997-08-19 |
IL116325A (en) | 1999-10-28 |
GB9425211D0 (en) | 1995-02-15 |
CA2165133A1 (en) | 1996-06-15 |
EP0717037A1 (fr) | 1996-06-19 |
RU2156239C2 (ru) | 2000-09-20 |
EE9500064A (et) | 1996-06-17 |
AR002257A1 (es) | 1998-03-11 |
FI955927A0 (fi) | 1995-12-11 |
FI955927A (fi) | 1996-06-15 |
AU4036895A (en) | 1996-06-20 |
NO955034D0 (no) | 1995-12-12 |
AU693614B2 (en) | 1998-07-02 |
SK155095A3 (en) | 1997-02-05 |
PL311736A1 (en) | 1996-06-24 |
BG63043B1 (bg) | 2001-02-28 |
NZ280646A (en) | 1996-08-27 |
MX9505063A (es) | 1997-01-31 |
CN1133837A (zh) | 1996-10-23 |
HUT73980A (en) | 1996-10-28 |
TW303362B (no) | 1997-04-21 |
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Legal Events
Date | Code | Title | Description |
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MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JUNE 2002 |