IL116325A - Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them - Google Patents
Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL116325A IL116325A IL11632595A IL11632595A IL116325A IL 116325 A IL116325 A IL 116325A IL 11632595 A IL11632595 A IL 11632595A IL 11632595 A IL11632595 A IL 11632595A IL 116325 A IL116325 A IL 116325A
- Authority
- IL
- Israel
- Prior art keywords
- imidazoles
- substituted
- naphthalenyl
- inden
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
IL116325A0 IL116325A0 (en) | 1996-03-31 |
IL116325A true IL116325A (en) | 1999-10-28 |
Family
ID=10765918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11632595A IL116325A (en) | 1994-12-14 | 1995-12-11 | Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them |
Country Status (26)
Country | Link |
---|---|
US (1) | US5658938A (xx) |
EP (1) | EP0717037A1 (xx) |
JP (1) | JPH08208622A (xx) |
KR (1) | KR960022474A (xx) |
CN (1) | CN1054376C (xx) |
AR (1) | AR002257A1 (xx) |
AU (1) | AU693614B2 (xx) |
BG (1) | BG63043B1 (xx) |
BR (1) | BR9505815A (xx) |
CA (1) | CA2165133A1 (xx) |
CZ (1) | CZ327195A3 (xx) |
EE (1) | EE9500064A (xx) |
FI (1) | FI955927A (xx) |
GB (1) | GB9425211D0 (xx) |
HU (1) | HUT73980A (xx) |
IL (1) | IL116325A (xx) |
IS (1) | IS4311A (xx) |
MX (1) | MX9505063A (xx) |
NO (1) | NO305316B1 (xx) |
NZ (1) | NZ280646A (xx) |
PL (1) | PL311736A1 (xx) |
RO (1) | RO113346B1 (xx) |
RU (1) | RU2156239C2 (xx) |
SK (1) | SK155095A3 (xx) |
TW (1) | TW303362B (xx) |
ZA (1) | ZA9510554B (xx) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
ZA981080B (en) * | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
JP2003532712A (ja) | 2000-05-08 | 2003-11-05 | オリオン コーポレーション | α2アドレナリン作用活性を有する新規な多環式インダニルイミダゾール |
TW200306783A (en) * | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
KR20080090545A (ko) * | 2006-01-27 | 2008-10-08 | 에프. 호프만-라 로슈 아게 | Cns 장애 치료용 2-이미다졸의 용도 |
JP5167265B2 (ja) * | 2006-10-19 | 2013-03-21 | エフ.ホフマン−ラ ロシュ アーゲー | 微量アミン関連受容体に親和性を有するアミノメチル−2−イミダゾール |
EP2076497B1 (en) * | 2006-10-19 | 2012-02-22 | F. Hoffmann-La Roche AG | Aminomethyl-4-imidazoles |
CN101535292A (zh) * | 2006-11-02 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 作为痕量胺相关受体的调节剂的取代的2-咪唑类化合物 |
AU2007321376A1 (en) * | 2006-11-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Substituted 4-imidazoles |
WO2008071574A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
CA2675221C (en) * | 2007-02-02 | 2016-02-23 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands |
RU2009134059A (ru) * | 2007-02-13 | 2011-03-20 | Шеринг Корпорейшн (US) | Функционально селективные агонисты альфа2с адренорецептора |
EP2398776A1 (en) * | 2007-02-13 | 2011-12-28 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
MX2009008777A (es) * | 2007-02-13 | 2009-08-25 | Schering Corp | Derivados y analogos de cromano como agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos. |
WO2008098857A1 (en) * | 2007-02-15 | 2008-08-21 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
CA2691082A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
WO2009003867A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
WO2009016048A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
EP2182935A1 (en) * | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | The use of benzamide derivatives for the treatment of cns disorders |
WO2009019149A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
US8383818B2 (en) | 2008-02-21 | 2013-02-26 | Merck Sharp & Dohme Corp. | Functionally selective alpha2C adrenoreceptor agonists |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
MX2011000464A (es) * | 2008-07-24 | 2011-03-01 | Hoffmann La Roche | Derivados de 4,5-dihidro-oxazol-2-ilo. |
EP2323734A1 (en) * | 2008-08-04 | 2011-05-25 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
US8324213B2 (en) | 2008-10-07 | 2012-12-04 | Merck Sharp & Dohme Corp. | Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
RU2621050C2 (ru) | 2012-01-12 | 2017-05-31 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические производные в качестве рецепторов, ассоциированных со следовыми аминами (taars) |
DK2895477T3 (en) | 2012-09-14 | 2018-01-15 | Hoffmann La Roche | Pyrazole carboxamide derivatives as TAAR modulators for use in the treatment of a variety of diseases such as depression, diabetes and Parkinson's disease |
ES2605632T3 (es) | 2012-09-17 | 2017-03-15 | F. Hoffmann-La Roche Ag | Derivados triazol carboxamida |
WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
CA2954098A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted azetidine derivatives as taar ligands |
CN106470994B (zh) | 2014-08-27 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物 |
EP3429352B1 (en) * | 2016-03-17 | 2021-05-05 | FMC Corporation | Process for converting s-enantiomer to its racemic form |
EP3757102A1 (en) | 2016-03-17 | 2020-12-30 | F. Hoffmann-La Roche AG | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-11 FI FI955927A patent/FI955927A/fi unknown
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1054376C (zh) | 2000-07-12 |
TW303362B (xx) | 1997-04-21 |
AR002257A1 (es) | 1998-03-11 |
NO305316B1 (no) | 1999-05-10 |
BG63043B1 (bg) | 2001-02-28 |
CZ327195A3 (en) | 1996-07-17 |
SK155095A3 (en) | 1997-02-05 |
EP0717037A1 (fr) | 1996-06-19 |
NZ280646A (en) | 1996-08-27 |
MX9505063A (es) | 1997-01-31 |
GB9425211D0 (en) | 1995-02-15 |
CA2165133A1 (en) | 1996-06-15 |
US5658938A (en) | 1997-08-19 |
ZA9510554B (en) | 1996-06-13 |
RO113346B1 (ro) | 1998-06-30 |
BG100208A (bg) | 1996-07-31 |
AU693614B2 (en) | 1998-07-02 |
AU4036895A (en) | 1996-06-20 |
KR960022474A (ko) | 1996-07-18 |
FI955927A0 (fi) | 1995-12-11 |
FI955927A (fi) | 1996-06-15 |
NO955034L (no) | 1996-06-17 |
BR9505815A (pt) | 1998-01-06 |
JPH08208622A (ja) | 1996-08-13 |
PL311736A1 (en) | 1996-06-24 |
CN1133837A (zh) | 1996-10-23 |
IL116325A0 (en) | 1996-03-31 |
RU2156239C2 (ru) | 2000-09-20 |
EE9500064A (et) | 1996-06-17 |
NO955034D0 (no) | 1995-12-12 |
IS4311A (is) | 1996-06-15 |
HUT73980A (en) | 1996-10-28 |
HU9503549D0 (en) | 1996-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |