FI955927A0 - Substituoidut 1H-imidatsolit - Google Patents
Substituoidut 1H-imidatsolitInfo
- Publication number
- FI955927A0 FI955927A0 FI955927A FI955927A FI955927A0 FI 955927 A0 FI955927 A0 FI 955927A0 FI 955927 A FI955927 A FI 955927A FI 955927 A FI955927 A FI 955927A FI 955927 A0 FI955927 A0 FI 955927A0
- Authority
- FI
- Finland
- Prior art keywords
- imidazoles
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
FI955927A0 true FI955927A0 (fi) | 1995-12-11 |
FI955927A FI955927A (fi) | 1996-06-15 |
Family
ID=10765918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955927A FI955927A (fi) | 1994-12-14 | 1995-12-11 | Substituoidut 1H-imidatsolit |
Country Status (26)
Country | Link |
---|---|
US (1) | US5658938A (fi) |
EP (1) | EP0717037A1 (fi) |
JP (1) | JPH08208622A (fi) |
KR (1) | KR960022474A (fi) |
CN (1) | CN1054376C (fi) |
AR (1) | AR002257A1 (fi) |
AU (1) | AU693614B2 (fi) |
BG (1) | BG63043B1 (fi) |
BR (1) | BR9505815A (fi) |
CA (1) | CA2165133A1 (fi) |
CZ (1) | CZ327195A3 (fi) |
EE (1) | EE9500064A (fi) |
FI (1) | FI955927A (fi) |
GB (1) | GB9425211D0 (fi) |
HU (1) | HUT73980A (fi) |
IL (1) | IL116325A (fi) |
IS (1) | IS4311A (fi) |
MX (1) | MX9505063A (fi) |
NO (1) | NO305316B1 (fi) |
NZ (1) | NZ280646A (fi) |
PL (1) | PL311736A1 (fi) |
RO (1) | RO113346B1 (fi) |
RU (1) | RU2156239C2 (fi) |
SK (1) | SK155095A3 (fi) |
TW (1) | TW303362B (fi) |
ZA (1) | ZA9510554B (fi) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
ZA981080B (en) * | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
AU5846901A (en) | 2000-05-08 | 2001-11-20 | Orion Corp | New polycyclic indanylimidazoles with alpha2 adrenergic activity |
TW200306783A (en) * | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
EP1981499A1 (en) * | 2006-01-27 | 2008-10-22 | F.Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of cns disorders |
DE602007005671D1 (de) * | 2006-10-19 | 2010-05-12 | Hoffmann La Roche | Aminomethyl-2-imidazole mit affinität zu mit dem trace-amin assoziierten rezeptoren |
MX2009003801A (es) * | 2006-10-19 | 2009-04-22 | Hoffmann La Roche | Aminometil-4-imidazoles. |
JP5064511B2 (ja) * | 2006-11-02 | 2012-10-31 | エフ.ホフマン−ラ ロシュ アーゲー | 痕跡アミン関連受容体調節剤としての置換2−イミダゾール |
CN101535298A (zh) * | 2006-11-16 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 取代的4-咪唑类化合物 |
ATE509628T1 (de) * | 2006-12-13 | 2011-06-15 | Hoffmann La Roche | Neue 2-imidazole als liganden für trace amine associated receptors (taar) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
NZ578260A (en) | 2007-02-02 | 2012-02-24 | Hoffmann La Roche | Novel 2-aminooxazolines as taar1 ligands for cns disorders |
EP2125749A2 (en) * | 2007-02-13 | 2009-12-02 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
US8470863B2 (en) * | 2007-02-13 | 2013-06-25 | Merck Sharp & Dohme, Corp. | Derivatives and analogs of chroman as functionally selective ALPHA2C adrenoreceptor agonists |
EP2398776A1 (en) * | 2007-02-13 | 2011-12-28 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
CN101616902B (zh) * | 2007-02-15 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体的2-氨基*唑啉类化合物 |
CN101687812A (zh) | 2007-07-02 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物 |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
KR101133862B1 (ko) * | 2007-07-27 | 2012-04-06 | 에프. 호프만-라 로슈 아게 | Taar 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민 |
BRPI0815038A2 (pt) * | 2007-08-02 | 2015-03-17 | Hoffmann La Roche | Uso de derivados de benzamida para o tratamento de transtornos do cns |
BRPI0814758A2 (pt) * | 2007-08-03 | 2015-03-03 | Hoffmann La Roche | Piridinacarboxamida e derivados de benzamida como ligantes taar1 |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
EP2257546B1 (en) | 2008-02-21 | 2012-08-15 | Merck Sharp & Dohme Corp. | Functionally selective alpha2c adrenoreceptor agonists |
PE20110215A1 (es) * | 2008-07-24 | 2011-03-31 | Hoffmann La Roche | Derivados de 4,5-dihidro-oxazol-2-ilo |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
EP2323734A1 (en) * | 2008-08-04 | 2011-05-25 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
EP2356106A1 (en) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
CA2856204A1 (en) | 2012-01-12 | 2013-07-18 | F. Hoffmann-La Roche Ag | Heterocyclic derivatives as trace amine associated receptors (taars) |
RS56747B1 (sr) | 2012-09-14 | 2018-03-30 | Hoffmann La Roche | Pirazol derivati karboksamida kao taar modulatori za upotrebu u lečenju nekoliko poremećaja, kao što su depresija, dijabetes i parkinsonova bolest |
BR112015001771B1 (pt) | 2012-09-17 | 2022-08-16 | F. Hoffmann-La Roche Ag | Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende |
WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
RU2017107521A (ru) | 2014-08-27 | 2018-10-01 | Ф. Хоффманн-Ля Рош Аг | Замещенные производные азетидина в качестве лигандов рецепторов следовых аминов taar |
CN106470994B (zh) | 2014-08-27 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物 |
MA43706B1 (fr) | 2016-03-17 | 2020-09-30 | Hoffmann La Roche | Dérivé de 5-éthyl-4-méthyl-pyrazole-3-carboxamide ayant une activité en tant qu'agoniste de taar |
CA3017751A1 (en) * | 2016-03-17 | 2017-09-21 | Fmc Corporation | Process for converting s-enantiomer to its racemic form |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-11 FI FI955927A patent/FI955927A/fi unknown
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO955034D0 (no) | 1995-12-12 |
HUT73980A (en) | 1996-10-28 |
AU4036895A (en) | 1996-06-20 |
IS4311A (is) | 1996-06-15 |
RO113346B1 (ro) | 1998-06-30 |
CZ327195A3 (en) | 1996-07-17 |
NO955034L (no) | 1996-06-17 |
AR002257A1 (es) | 1998-03-11 |
CA2165133A1 (en) | 1996-06-15 |
CN1133837A (zh) | 1996-10-23 |
BR9505815A (pt) | 1998-01-06 |
GB9425211D0 (en) | 1995-02-15 |
FI955927A (fi) | 1996-06-15 |
AU693614B2 (en) | 1998-07-02 |
MX9505063A (es) | 1997-01-31 |
EP0717037A1 (fr) | 1996-06-19 |
EE9500064A (et) | 1996-06-17 |
NZ280646A (en) | 1996-08-27 |
TW303362B (fi) | 1997-04-21 |
HU9503549D0 (en) | 1996-02-28 |
SK155095A3 (en) | 1997-02-05 |
IL116325A (en) | 1999-10-28 |
BG63043B1 (bg) | 2001-02-28 |
RU2156239C2 (ru) | 2000-09-20 |
KR960022474A (ko) | 1996-07-18 |
CN1054376C (zh) | 2000-07-12 |
JPH08208622A (ja) | 1996-08-13 |
ZA9510554B (en) | 1996-06-13 |
NO305316B1 (no) | 1999-05-10 |
US5658938A (en) | 1997-08-19 |
PL311736A1 (en) | 1996-06-24 |
BG100208A (bg) | 1996-07-31 |
IL116325A0 (en) | 1996-03-31 |
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