RO113346B1 - Derivati de 1h-imidazol si procedee pentru prepararea acestora - Google Patents

Derivati de 1h-imidazol si procedee pentru prepararea acestora Download PDF

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Publication number
RO113346B1
RO113346B1 RO95-02138A RO9502138A RO113346B1 RO 113346 B1 RO113346 B1 RO 113346B1 RO 9502138 A RO9502138 A RO 9502138A RO 113346 B1 RO113346 B1 RO 113346B1
Authority
RO
Romania
Prior art keywords
formula
compound
imidazole
tetrahydro
alkyl
Prior art date
Application number
RO95-02138A
Other languages
English (en)
Romanian (ro)
Inventor
Jean-Pierre Gerrts
Genevieve Motte
Edmond Differding
Jean-Pierre Henichart
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of RO113346B1 publication Critical patent/RO113346B1/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RO95-02138A 1994-12-14 1995-12-08 Derivati de 1h-imidazol si procedee pentru prepararea acestora RO113346B1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
RO113346B1 true RO113346B1 (ro) 1998-06-30

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
RO95-02138A RO113346B1 (ro) 1994-12-14 1995-12-08 Derivati de 1h-imidazol si procedee pentru prepararea acestora

Country Status (26)

Country Link
US (1) US5658938A (cg-RX-API-DMAC7.html)
EP (1) EP0717037A1 (cg-RX-API-DMAC7.html)
JP (1) JPH08208622A (cg-RX-API-DMAC7.html)
KR (1) KR960022474A (cg-RX-API-DMAC7.html)
CN (1) CN1054376C (cg-RX-API-DMAC7.html)
AR (1) AR002257A1 (cg-RX-API-DMAC7.html)
AU (1) AU693614B2 (cg-RX-API-DMAC7.html)
BG (1) BG63043B1 (cg-RX-API-DMAC7.html)
BR (1) BR9505815A (cg-RX-API-DMAC7.html)
CA (1) CA2165133A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ327195A3 (cg-RX-API-DMAC7.html)
EE (1) EE9500064A (cg-RX-API-DMAC7.html)
FI (1) FI955927A7 (cg-RX-API-DMAC7.html)
GB (1) GB9425211D0 (cg-RX-API-DMAC7.html)
HU (1) HUT73980A (cg-RX-API-DMAC7.html)
IL (1) IL116325A (cg-RX-API-DMAC7.html)
IS (1) IS4311A (cg-RX-API-DMAC7.html)
MX (1) MX9505063A (cg-RX-API-DMAC7.html)
NO (1) NO305316B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ280646A (cg-RX-API-DMAC7.html)
PL (1) PL311736A1 (cg-RX-API-DMAC7.html)
RO (1) RO113346B1 (cg-RX-API-DMAC7.html)
RU (1) RU2156239C2 (cg-RX-API-DMAC7.html)
SK (1) SK155095A3 (cg-RX-API-DMAC7.html)
TW (1) TW303362B (cg-RX-API-DMAC7.html)
ZA (1) ZA9510554B (cg-RX-API-DMAC7.html)

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CN101687811A (zh) * 2007-07-03 2010-03-31 弗·哈夫曼-拉罗切有限公司 4-咪唑啉类及其作为抗抑郁剂的应用
EP2183216A1 (en) * 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
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JP5341084B2 (ja) * 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
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AU2009273324A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
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US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
JP5872069B2 (ja) 2012-01-12 2016-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 微量アミン関連受容体（ｔａａｒ）としての複素環誘導体
JP2015531782A (ja) 2012-09-14 2015-11-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ うつ病、糖尿病及びパーキンソン病のような幾つかの障害の処置において使用するためのｔａａｒ調節薬としてのピラゾールカルボキサミド誘導体
BR112015001771B1 (pt) 2012-09-17 2022-08-16 F. Hoffmann-La Roche Ag Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
CN107001259B (zh) 2014-08-27 2019-12-06 豪夫迈·罗氏有限公司 作为taar配体的取代的氮杂环丁烷衍生物
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Also Published As

Publication number Publication date
KR960022474A (ko) 1996-07-18
NZ280646A (en) 1996-08-27
TW303362B (cg-RX-API-DMAC7.html) 1997-04-21
NO955034L (no) 1996-06-17
RU2156239C2 (ru) 2000-09-20
IS4311A (is) 1996-06-15
FI955927A0 (fi) 1995-12-11
CZ327195A3 (en) 1996-07-17
BG63043B1 (bg) 2001-02-28
NO305316B1 (no) 1999-05-10
CA2165133A1 (en) 1996-06-15
IL116325A0 (en) 1996-03-31
AU4036895A (en) 1996-06-20
GB9425211D0 (en) 1995-02-15
PL311736A1 (en) 1996-06-24
FI955927L (fi) 1996-06-15
MX9505063A (es) 1997-01-31
US5658938A (en) 1997-08-19
AR002257A1 (es) 1998-03-11
AU693614B2 (en) 1998-07-02
EP0717037A1 (fr) 1996-06-19
BG100208A (bg) 1996-07-31
CN1054376C (zh) 2000-07-12
HUT73980A (en) 1996-10-28
NO955034D0 (no) 1995-12-12
JPH08208622A (ja) 1996-08-13
FI955927A7 (fi) 1996-06-15
BR9505815A (pt) 1998-01-06
HU9503549D0 (en) 1996-02-28
CN1133837A (zh) 1996-10-23
SK155095A3 (en) 1997-02-05
IL116325A (en) 1999-10-28
EE9500064A (et) 1996-06-17
ZA9510554B (en) 1996-06-13

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